MicroRNAs are involved in cervical cancer development, progression, clinical outcome and improvement treatment response (Review)
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Víctor González-Quintana, Lizbeth Palma-Berré, Alma D. Campos-Parra, Eduardo López‑Urrutia, Oscar Peralta-Zaragoza, Rafael Vazquez-Romo, Carlos Pérez-Plasencia |
Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines
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Puteri Baharuddin, Nazilah Satar, Kamal Shaik Fakiruddin, Norashikin Zakaria, Moon Nian Lim, Narazah Mohd Yusoff, Zubaidah Zakaria, Badrul Hisham Yahaya |
Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells
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Lingqing Lin, Zanxi Fang, Huayue Lin, Hanyu You, Jiajia Wang, Yuanhui Su, Fen Wang, Zhong‑Ying Zhang |
Expansion of quiescent lung adenocarcinoma CD8+ T cells by MUC1-8-mer peptide-T2 cell-β2 microglobulin complexes
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J. A. Atzin-Méndez, J. S. López-González, R. Báez, M. C. Arenas-Del Angel, L. F. Montaño, D. Silva-Adaya, R. Lascurain, P. Gorocica |
Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo
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Tao Hu, Pei Li, Zhongguang Luo, Xiaoyu Chen, Jingyang Zhang, Chunyao Wang, Ping Chen, Ziming Dong |
Latexin exhibits tumor-suppressor potential in pancreatic ductal adenocarcinoma
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Zhanxiong Xue, Yuhui Zhou, Cheng Wang, Jihang Zheng, Pu Zhang, Lingling Zhou, Liang Wu, Yunfeng Shan, Mengsi Ye, Yun He, Zhenzhai Cai |
Suppressive effects of 3-bromopyruvate on the proliferation and the motility of hepatocellular carcinoma cells
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Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige |
Methylation-induced silencing of miR-34a enhances chemoresistance by directly upregulating ATG4B-induced autophagy through AMPK/mTOR pathway in prostate cancer
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Haiqiu Liao, Yang Xiao, Yingbin Hu, Yangming Xiao, Zhaofa Yin, Liang Liu, Xiaopeng Kang, Yonggang Chen |
MicroRNA-21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF-β pathways
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Mingli Han, Fang Wang, Yuanting Gu, Xinhong Pei, Guangcheng Guo, Chao Yu, Lin Li, Mingzhi Zhu, Youyi Xiong, Yimeng Wang |
TMPRSS3 modulates ovarian cancer cell proliferation, invasion and metastasis
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Dan Zhang, Shuang Qiu, Qi Wang, Jianhua Zheng |
Effects of lentivirus-mediated shRNA targeting integrin-linked kinase on oral squamous cell carcinoma in vitro and in vivo
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Lin Que, Dan Zhao, Xiu-Fa Tang, Ji-Yuan Liu, Xiang-Yu Zhang, Yu-Hua Zhan, Lei Zhang |
Effects of HPV-16 infection on hypopharyngeal squamous cell carcinoma and FaDu cells
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Wuhao Lu, Long Feng, Ping Li, Yuanyuan Wang, Yuwen Du, Xiaonan Chen, Shujun Wu, Guoqiang Zhao, Weihua Lou |
Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression
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Wen-Hui Weng, Wai-Hung Leung, Yeu-Jye Pang, Hsi-Hsien Hsu |
The natural compound codonolactone attenuates TGF-β1-mediated epithelial-to-mesenchymal transition and motility of breast cancer cells
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Jianjiang Fu, Xiaoqin Ke, Songlin Tan, Ting Liu, Shan Wang, Junchao Ma, Hong Lu |
The MRTF-A/B function as oncogenes in pancreatic cancer
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Zhao Song, Zhao Liu, Jing Sun, Feng-Lei Sun, Chuan-Zhi Li, Jiu-Zheng Sun, Li-You Xu |
Promoter hypermethylation of PTPL1, PTPN6, DAPK, p16 and 5-azacitidine inhibits growth in DLBCL
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Wenming Wang, Jing Wang, Zhengqian Li, Mingxia Zhu, Zhe Zhang, Yanfang Wang, Hongmei Jing |
Multidrug resistance-associated protein 4 is a determinant of arsenite resistance
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Bo Yuan, Yuta Yoshino, Hisayo Fukushima, Svetlana Markova, Norio Takagi, Hiroo Toyoda, Deanna L. Kroetz |
Significance of DEK overexpression for the prognostic evaluation of non-small cell lung carcinoma
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Xin Liu, Dongdong Qi, Jujie Qi, Zeshu Mao, Xiangdan Li, Jinhui Zhang, Jinzi Li, Wenbin Gao |
Recombinant HE4 protein promotes proliferation of pancreatic and endometrial cancer cell lines
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Qinsheng Lu, Haibin Chen, Christopher Senkowski, Jianhao Wang, Xue Wang, Steven Brower, Wayne Glasgow, David Byck, Shi-Wen Jiang, Jinping Li |
Construction of human single-chain variable fragment antibodies of medullary thyroid carcinoma and single photon emission computed tomography/computed tomography imaging in tumor-bearing nude mice
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Qiong Liu, Hua Pang, Xiaoli Hu, Wenbo Li, Jimei Xi, Lu Xu, Jing Zhou |
Platelet-activating factor promotes motility in breast cancer cells and disrupts non-transformed breast acinar structures
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V. Libi Anandi, K. A. Ashiq, K. Nitheesh, M. Lahiri |
The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway
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Xiuying Ma, Deqing Wu, Shu Zhou, Feng Wan, Hua Liu, Xiaorong Xu, Xuanfu Xu, Yan Zhao, Maochun Tang |
Imatinib mesylate induces mitochondria-dependent apoptosis and inhibits invasion of human pigmented villonodular synovitis fibroblast-like synovial cells
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Kang Chen, Qiao Ren, Xiao-Rui Han, Xiao-Nan Zhang, Bo Wei, Xi-Zhuang Bai |
Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway
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Tao Xiang, Rushan Fei, Zhe Wang, Zhonglei Shen, Jing Qian, Wenbin Chen |
Identification of the metastasis potential and its associated genes in melanoma multinucleated giant cells using the PHA-ECM830 fusion method
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Ruifang Mi, Chunxiao Pan, Yiqiang Zhou, Yuanbo Liu, Guishan Jin, Fusheng Liu |
The differentiation of hMSCs counteracts their migration capability and pro‑angiogenic effects in vitro
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A. Scherzed, S. Hackenberg, K. Froelich, K. Rak, P. Schendzielorz, T. Gehrke, R. Hagen, N. Kleinsasser |
β-elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The role of MAPK, ROS activation and glutathione depletion
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Tsu‑Tuan Wu, Chien‑Lin Lu, Hen‑I Lin, Bing‑Fang Chen, Guey‑Mei Jow |
Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability
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Hyun-Woo Kim, Soo -A Kim, Sang-Gun Ahn |
Adenovirus-mediated p53 and ING4 gene co‑transfer elicitssynergistic antitumor effects through enhancement ofp53 acetylation in breast cancer
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Jie Wu, Yanbo Zhu, Chun Xu, Hong Xu, Xiumin Zhou, Jicheng Yang, Yufeng Xie, Min Tao |
Impact of KITENIN on tumor angiogenesis and lymphangiogenesis in colorectal cancer
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Hyung-Hoon Oh, Kang-Jin Park, Nuri Kim, Sun-Young Park, Young‑Lan Park, Chan-Young Oak, Dae-Seong Myung, Sung-Bum Cho, Wan‑Sik Lee, Kyung-Keun Kim, Young-Eun Joo |
Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells
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Ichiro Ota, Takashi Masui, Miyako Kurihara, Jong-In Yook, Shinji Mikami, Takahiro Kimura, Keiji Shimada, Noboru Konishi, Katsunari Yane, Toshiaki Yamanaka, Tadashi Kitahara |
Type III TGF-β receptor inhibits cell proliferation and migration in salivary glands adenoid cystic carcinoma by suppressing NF-κB signaling
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Dongyang Xu, Duo Li, Zhiyong Lu, Xingli Dong, Xiaofeng Wang |
miR-146b-5p promotes invasion and metastasis contributing to chemoresistance in osteosarcoma by targeting zinc and ring finger 3
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Enjie Xu, Jianquan Zhao, Jun Ma, Ce Wang, Chenglin Zhang, Heng Jiang, Jianyang Cheng, Rui Gao, Xuhui Zhou |
miR-124 suppresses the migration and invasion of glioma cells in vitro via Capn4
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Jia-Jun Cai, Zeng-Xin Qi, Ling-Chao Chen, Yu Yao, Yan Gong, Ying Mao |
Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells
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Zhiping He, Allen Y. Chen, Yon Rojanasakul, Gary O. Rankin, Yi Charlie Chen |
Correlation between the promoter methylation status of ATP-binding cassette sub-family G member 2 and drug sensitivity in colorectal cancer cell lines
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Hyun‑Hye Moon, Sung‑Hee Kim, Ja‑Lok Ku |
Resolvin D1 and E1 alleviate the progress of hepatitis toward liver cancer in long-term concanavalin A-induced mice through inhibition of NF-κB activity
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Haoyu Kuang, Xiaoli Hua, Jianhui Zhou, Rui Yang |
Upregulation of long non-coding RNA PRNCR1 in colorectal cancer promotes cell proliferation and cell cycle progression
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Liu Yang, Mantang Qiu, Youtao Xu, Jie Wang, Yanyan Zheng, Ming Li, Lin Xu, Rong Yin |
Comparison of human gut microbiota in control subjects and patients with colorectal carcinoma in adenoma: Terminal restriction fragment length polymorphism and next-generation sequencing analyses
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Chika Kasai, Kazushi Sugimoto, Isao Moritani, Junichiro Tanaka, Yumi Oya, Hidekazu Inoue, Masahiko Tameda, Katsuya Shiraki, Masaaki Ito, Yoshiyuki Takei, Kojiro Takase |
Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy
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Xiu-Wu Pan, Lin Li, Yi Huang, Hai Huang, Dan-Feng Xu, Yi Gao, Lu Chen, Ji-Zhong Ren, Jian-Wei Cao, Yi Hong, Xin-Gang Cui |
Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation
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Hao Li, Yaodong Liu, Yumin Jiao, Anchen Guo, Xiaoxue Xu, Xianjun Qu, Shuo Wang, Jizong Zhao, Ye Li, Yong Cao |
Jumonji domain containing 2A predicts prognosis and regulates cell growth in lung cancer depending on miR-150
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Weihua Xu, Kanqiu Jiang, Mingjing Shen, Yongbing Chen, Hao-Yue Huang |
TCEB2 confers resistance to VEGF‑targeted therapy in ovarian cancer
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Zhuo Deng, Jiancheng Zhou, Xi Han, Xu Li |
MicroRNA-616 promotes the migration, invasion and epithelial-mesenchymal transition of HCC by targeting PTEN
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Di Zhang, Peihua Zhou, Wei Wang, Xiaolong Wang, Junhui Li, Xuejun Sun, Li Zhang |
Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway
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Qi Li, Yiming Lai, Chengbin Wang, Guibin Xu, Zheng He, Xiaohong Shang, Yi Sun, Fan Zhang, Leyuan Liu, Hai Huang |
Selecting molecular therapeutic drug targets based on the expression profiles of intrahepatic cholangiocarcinomas and miRNA-mRNA regulatory networks
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Boshi Sun, Changming Xie, Tongsen Zheng, Dalong Yin, Jiabei Wang, Yingjian Liang, Yuejin Li, Guangchao Yang, Huawen Shi, Tiemin Pei, Jihua Han, Lianxin Liu |
Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance
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Masakazu Sato, Kei Kawana, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Takahashi, Katsuyuki Adachi, Kazunori Nagasaka, Yoko Matsumoto, Osamu Wada‑Hiraike, Katsutoshi Oda, Yutaka Osuga, Tomoyuki Fujii |
miRNA expression profile of vulvar squamous cell carcinoma and identification of the oncogenic role of miR-590-5p
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Xiuhua Yang, Xin Wu |
Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells
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Chuang Du, Xin Wang, Junling Zhang, Xiangzheng Liu, Jing Zhu, Yucun Liu |
Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma
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Lu Yan, Yuan Wang, Zhi-Zhi Wang, Yan-Ting Rong, Lin-Lin Chen, Qian Li, Ting Liu, Yong-Heng Chen, Yan-Dong Li, Zhao-Hong Huang, Jie Peng |
Schwann cells promote EMT and the Schwann-like differentiation of salivary adenoid cystic carcinoma cells via the BDNF/TrkB axis
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Chun Shan, Jianhua Wei, Rui Hou, Baolei Wu, Zihui Yang, Lei Wang, Delin Lei, Xinjie Yang |
The clinical significance of transforming acidic coiled-coil protein 3 expression in non-small cell lung cancer
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Feng Jiang, Bohua Kuang, Yi Que, Zhirui Lin, Li Yuan, Wei Xiao, Ruiqing Peng, Xiaoshi Zhang, Xing Zhang |
Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway
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Guangwei Zhong, Xi Chen, Xia Fang, Dongsheng Wang, Mingxuan Xie, Qiong Chen |
Biomarker triplet NAMPT/VEGF/HER2 as a de novo detection panel for the diagnosis and prognosis of human breast cancer
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Yanyan Zhu, Meiyan Guo, Lingyun Zhang, Tao Xu, Li Wang, Guoxiong Xu |
Esophageal squamous cell carcinoma cell proliferation induced by exposure to low concentration of cigarette smoke extract is mediated via targeting miR-101-3p/COX-2 pathway
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Jian Gong, Yi Chu, Meili Xu, Jirong Huo, Liang Lv |
Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN‑regulated PI3K/Akt signaling pathway
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Xiaoping Jing, Weiwei Cheng, Shiying Wang, Pin Li, Li He |
Knockdown of long non-coding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer
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Xiao-Dong Yang, Hong-Tao Xu, Xiao-Hui Xu, Gan Ru, Wei Liu, Jun-Jia Zhu, Yong-You Wu, Kui Zhao, Yong Wu, Chun-Gen Xing, Shu-Yu Zhang, Jian-Ping Cao, Ming Li |
PBOV1 correlates with progression of ovarian cancer and inhibits proliferation of ovarian cancer cells
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Lan Wang, Chun-Hao Niu, Shu Wu, Hong-Mei Wu, Fei Ouyang, Mian He, Shan-Yang He |
miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer
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Chun Xu, Sen Li, Tengfei Chen, Haibo Hu, Cheng Ding, Zhenlei Xu, Jun Chen, Zeyi Liu, Zhe Lei, Hong-Tao Zhang, Chang Li, Jun Zhao |
n-3 polyunsaturated fatty acids reverse the development of polyps in ApcMin/+ transgenic mice
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Maria Notarnicola, Valeria Tutino, Maria Gabriella Caruso, Antonio Francavilla |
Pien Tze Huang inhibits the proliferation, and induces the apoptosis and differentiation of colorectal cancer stem cells via suppression of the Notch1 pathway
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Fei Qi, Lihui Wei, Aling Shen, Youqin Chen, Jiumao Lin, Jianfeng Chu, Qiaoyan Cai, Jie Pan, Jun Peng |
A positive feedback loop of p53/miR-19/TP53INP1 modulates pancreatic cancer cell proliferation and apoptosis
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Xiaofang Wang, Lei Wang, Qingjiang Mo, Ankui Jia, Yuqian Dong, Guoqiang Wang |
Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1
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Ju-Hee Lee, Jin-Shang Kim, Sang-Youel Park, You-Jin Lee |
Ezrin-radixin-moesin-binding phosphoprotein-50 regulates EGF-induced AKT activation through interaction with EGFR and PTEN
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Junfang Zheng, Yuanping Dai, Zhiyu Yang, Longyan Yang, Zhiqiang Peng, Ran Meng, Ying Xiong, Junqi He |
Human chorionic gonadotropin β subunit affects the expression of apoptosis-regulating factors in ovarian cancer
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Anna Szczerba, Aleksandra Śliwa, Marta Kubiczak, Ewa Nowak-Markwitz, Anna Jankowska |
Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion
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Bo Ra You, Woo Hyun Park |
Klotho inhibits human follicular thyroid cancer cell growth and promotes apoptosis through regulation of the expression of stanniocalcin-1
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Dong Dai, Qi Wang, Xiaofeng Li, Jianjing Liu, Xiaoying Ma, Wengui Xu |
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma
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Shoulin Zhang, Dongmei Zhang, Chunguang Yi, Yinping Wang, Hongan Wang, Jian Wang |
Bergapten induces metabolic reprogramming in breast cancer cells
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Marta Santoro, Carmela Guido, Francesca De Amicis, Diego Sisci, Erika Cione, Dolce Vincenza, Ada Donà, Maria Luisa Panno, Saveria Aquila |
Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF‑2α expression in lung cancer cells under normoxia and hypoxia
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Arnoldo Aquino-Gálvez, Georgina González-Ávila, Javier Delgado-Tello, Manuel Castillejos-López, Criselda Mendoza-Milla, Joaquín Zúñiga, Marco Checa, Héctor Aquiles Maldonado-Martínez, Axel Trinidad-López, José Cisneros, Luz María Torres-Espíndola, Claudia Hernández-Jiménez, Bettina Sommer, Carlos Cabello-Gutiérrez, Luis H. Gutiérrez-González |
Overexpression of lysine-specific demethylase 1 promotes androgen-independent transition of human prostate cancer LNCaP cells through activation of the AR signaling pathway and suppression of the p53 signaling pathway
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Xuechao Li, Tao Li, Dehong Chen, Peng Zhang, Yarong Song, Hongxue Zhu, Yajun Xiao, Yifei Xing |
Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel
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Manabu Seino, Masashi Okada, Hirotsugu Sakaki, Hiroyuki Takeda, Hikaru Watarai, Shuhei Suzuki, Shizuka Seino, Kenta Kuramoto, Tsuyoshi Ohta, Satoru Nagase, Hirohisa Kurachi, Chifumi Kitanaka |
[Corrigendum] Trastuzumab and docetaxel in a preclinical organotypic breast cancer model using tissue slices from mammary fat pad: Translational relevance
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Loredana Vesci, Valeria Carollo, Giuseppe Roscilli, Luigi Aurisicchio, Fabiana Fosca Ferrara, Luigi Spagnoli, Rita De Santis |
Τρίτη 12 Ιανουαρίου 2016
Oncology Reports
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma.
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma.
Head Neck. 2016 Jan 11;
Authors: Takahashi Y, Lee J, Pickering C, Bell D, Jiffar TW, Myers JN, Hanna EY, Kupferman ME
Abstract
BACKGROUND: Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive cancer. Despite multimodal therapy, the prognosis in SNUC remains poor, and new therapies are needed. Thus, the purpose of this study was to explore potential therapeutic targets in SNUC.
METHODS: Using the human-derived SNUC MDA8788-6 cell line, we performed whole genome single nucleotide polymorphism (SNP) analysis to identify copy number changes in this line. Protein expression levels were evaluated by Western blotting. Cell growth inhibition was assessed by methylthiazol tetrazolium (MTT) and clonogenic assays. The mouse flank model was used to examine the effect of growth inhibition in vivo.
RESULTS: The ERBB2 gene was highly amplified and cell extracts showed human epidermal growth factor receptor 2 (HER2) was overexpressed and phosphorylated in MDA8788-6. Lapatinib effectively inhibited the HER2 signaling pathway in our SNUC cell line. HER2 inhibition successfully suppressed the cell growth of MDA8788-6 cells both in vitro and in vivo.
CONCLUSION: Targeting HER2 may be a promising avenue for the development of novel therapies for SNUC. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.
PMID: 26752332 [PubMed - as supplied by publisher]
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Audiological comparison between two different clips prostheses in stapes surgery.
Audiological comparison between two different clips prostheses in stapes surgery.
Rev Laryngol Otol Rhinol (Bord). 2015;136(1):33-6
Authors: Potena M, Portmann D, Guindi S
Abstract
OBJECTIVES: To compare audiometric results and complications of stapes surgery with two different types of piston prosthesis, the Portmann Clip Piston (Medtronic) (PCP) and the Soft Clip Piston (Kurz) (SCP).
MATERIAL AND METHODS: Study conducted on 64 patients who underwent primary stapedotomy from 2008 to 2011. We matched for each case of stapedotomy with the PCP (Medtronic Xomed Inc. Portmann Clip Piston Stainless Steel/Fluoroplastic) a case with the SCP (Heinz Kurz GmbH Medizintechnik Soft Piston Clip Titanium). Each group consisted of 32 patients, and patients in both groups were matched with respect to gender, age, bilateral or unilateral otosclerosis, otological symptoms (tinnitus, vertigo or dizziness), family history, operated side and the Portmann grading for otosclerosis. The length of the prosthesis used was reported. Post-operative complications such as tinnitus, vertigo, hearing loss and altered taste were documented. Each patient was subjected to a preoperative and postoperative audiogram (follow-up at the second month after the surgery). We used the Student test for statistical analysis. Statistical significance was set at < 0.01.
RESULTS: None of the patients experienced a post-operative hearing loss and none required a later revision surgery. No statistically significant difference was found between the two populations regarding demographic data (age, sex, side, bilaterality, family history, stage and lenght of piston) and hearing level (> 0.01) in the air, bone conduction and air-bone gap (ABG). Postoperative complications did not result to be significantly different between the two groups. Also, both groups showed a significant improvement (< 0.01) in the post-operative air, bone conduction and air-bone gap. There was no statistically significant difference (> 0.01) between the post-operative hearing results (bone conduction, air conduction, air-bone gap) using the two pistons. The mean ABG improvement was respectively 16.63 dB in the SCP group and 20.59 dB in the PCP group.
CONCLUSION: The titanium Soft clip piston (SCP) is a good alternative to the Portmann clip piston (PCP). Nevertheless there are some differences in the surgical fixing of these two pistons in the correct position.
PMID: 26749603 [PubMed - in process]
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Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps.
Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps.
Int Forum Allergy Rhinol. 2016 Jan 11;
Authors: Carroll WW, Schlosser RJ, O'Connell BP, Soler ZM, Mulligan JK
Abstract
BACKGROUND: Vitamin D3 (VD3) is a steroid hormone with known antiproliferative properties. Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have been shown to be VD3-deficient. Moreover, VD3 deficiency is associated with worse disease in patients with CRSwNP. One cell type thought to play a role in chronic rhinosinusitis (CRS) is the human sinonasal fibroblast (HSNF). The aim of this study was to investigate VD3 deficiency and HSNF proliferation in CRSwNP.
METHODS: Blood and sinus tissue explants were collected at the time of surgery from patients with CRSwNP (n = 15). Control subjects (n = 12) were undergoing surgery for cerebrospinal fluid leak repair or to remove non-hormone-secreting pituitary tumors. Ex vivo HSNF proliferation was analyzed with flow cytometry using expression of fibroblast-specific protein (FSP) and the proliferation marker Ki67. Plasma levels of 25-hydroxyvitamin D3 (25VD3) were measured by enzyme-linked immunosorbent assay. In vitro analysis of HSNF proliferation after treatment with calcitriol (1,25VD3) was performed using carboxyfluorescein succinimidyl ester (CFSE) and analyzed with flow cytometry.
RESULTS: In CRSwNP patients there was an inverse correlation between 25VD3 and proliferating HSNFs (p = 0.0135). This correlation was not seen for control patients (p = 0.3869). In vitro analysis showed that HSNFs from patients with CRSwNP had a higher proliferation index at baseline than HSNFs from control patients (p < 0.01). When treated with 1,25VD3, there was a significant decrease in HSNF proliferation index in patients with CRSwNP (p < 0.01), but not control patients.
CONCLUSION: VD3 deficiency is associated with increased HSNF proliferation in CRSwNP. Further investigation into how HSNFs and VD3 impact CRSwNP pathophysiology is warranted.
PMID: 26750566 [PubMed - as supplied by publisher]
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Quantifying lingual coarticulation using ultrasound imaging data collected with and without head stabilisation.
 | Related Articles |
Quantifying lingual coarticulation using ultrasound imaging data collected with and without head stabilisation.
Clin Linguist Phon. 2015 Apr;29(4):249-65
Authors: Zharkova N, Gibbon FE, Hardcastle WJ
Abstract
Previous studies reporting the use of ultrasound tongue imaging with clinical populations have generally provided qualitative information on tongue movement. Meaningful quantitative measures for use in the clinic typically require the speaker's head to be stabilised in relation to a transducer, which may be uncomfortable, and unsuitable for young children. The objective of this study was to explore the applicability of quantitative measurements of stabilisation-free tongue movement data, by comparing ultrasound data collected from 10 adolescents, with and without head stabilisation. Several measures of tongue shape were used to quantify coarticulatory influence from two contrasting vowels on four different consonants. Only one of the measures was completely unaffected by the stabilisation condition for all the consonants. The study also reported cross-consonant differences in vowel-related coarticulatory effects. The implications of the findings for the theory of coarticulation and for potential applications of stabilisation-free tongue curve measurements in clinical studies are discussed.
PMID: 25651199 [PubMed - indexed for MEDLINE]
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Norwegian words: A lexical database for clinicians and researchers.
| Related Articles |
Norwegian words: A lexical database for clinicians and researchers.
Clin Linguist Phon. 2015 Apr;29(4):276-90
Authors: Lind M, Simonsen HG, Hansen P, Holm E, Mevik BH
Abstract
All words have properties linked to form, meaning and usage patterns which influence how easily they are accessed from the mental lexicon in language production, perception and comprehension. Examples of such properties are imageability, phonological and morphological complexity, word class, argument structure, frequency of use and age of acquisition. Due to linguistic and cultural variation the properties and the values associated with them differ across languages. Hence, for research as well as clinical purposes, language specific information on lexical properties is needed. To meet this need, an electronically searchable lexical database with more than 1600 Norwegian words coded for more than 12 different properties has been established. This article presents the content and structure of the database as well as the search options available in the interface. Finally, it briefly describes some of the ways in which the database can be used in research, clinical practice and teaching.
PMID: 25588015 [PubMed - indexed for MEDLINE]
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