Eosinophils Correlate with Epithelial-Mesenchymal Transition in Chronic Rhinosinusitis with Nasal Polyps

xlomafota13 shared this article with you from Inoreader Eosinophils Correlate with Epithelial-Mesenchymal Transition in Chronic Rhinosinusitis with Nasal Polyps Via O.R.L. Journal for oto-rhino-laryngology and its borderlands Introduction: Chronic inflammation and tissue remodeling always occur together in chronic rhinosinusitis (CRS). Epithelial-mesenchymal transition (EMT) plays a critical role in airway remodeling. Objective: Changes of epithelial cells in sinus mucosa in different subtypes of CRS, especially in eosinophilic chronic rhinosinusitis with nasal polyps, and the role of EMT and eosinophils (EOS) in airway remodeling are still unknown. Methods: We included 85 patients in this study. They were divided into 4 groups: a normal control (NC) group, a chronic rhinosinusitis without nasal polyps (CRSsNP) group, an eosinophilic chronic rhinosinusitis with nasal polyps (ECRSwNP) group, and a noneosinophilic chronic rhinosinusitis with nasal polyps (non-ECRSwNP) group. Clinical data were all collected and analyzed. Standard hematoxylin and eosin staining, immunohistochemical staining, and 2-color immunofluorescence staining were performed. Biomarkers of EMT, epithelial cadherin, and vimentin were labeled. The immunohistochemistry results of each group were counted and statistically analyzed. Results and Conclusion: E-cadherin was downregulated, and vimentin was upregulated in epithelial tissue from the ECRSwNP group, compared with that from the control group and the other groups. The number of vimentin-expressing epithelial cells correlated with sinus CT imaging Lund-Mackay scores (r = 0.560, p #x3c; 0.001). Moreover, expression levels of vimentin in the epithelium were associated with numbers of infiltrating EOS in tissues (r = 0.710, p #x3c; 0.001) and the peripheral blood EOS ratio (r = 0.594, p #x3c; 0.001). EMT occurred in patients with CRSwNP, especially in those with ECRSwNP. Epithelial reprogramming correlates with eosinophil infiltration and disease severity. Eosinophils contributed to impairment of epithelial function and promoted EMT in CRSwNP. ORL View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Osteoradionecrosis of the hyoid presenting as acute airway compromise

xlomafota13 shared this article with you from Inoreader Osteoradionecrosis of the hyoid presenting as acute airway compromise Via Head & Neck Abstract Background Osteoradionecrosis (ORN) of the mandible is a well-known complication of radiation therapy for head and neck cancer. However, few reports have described hyoid bone ORN and its clinical implications. Methods We describe a retrospective case series of previously irradiated patients who were seen with sudden airway compromise, found to have underlying pathological hyoid fractures secondary to osteoradionecrosis. Results Six patients within postchemoradiation period (3–9 months) for oropharyngeal squamous cell carcinoma were seen with acute-onset dyspnea. Computed topography (CT) imaging was remarkable for severe airway luminal narrowing and pathological hyoid fractures. All six patients required urgent intervention with direct laryngoscopy and tracheostomy. Intraoperatively, five patients were seen with exposed necrotic hyoid bones. Conclusion The hyoid and its associated musculature strongly influence upper airway patency. ORN may compromise its physiological function and leads to acute airway compromise. Hyoid ORN may hold significant and imperative clinical implications in head and neck cancer post-treatment surveillance. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Salivary gland adenocarcinoma metastatic to the pituitary gland

xlomafota13 shared this article with you from Inoreader Salivary gland adenocarcinoma metastatic to the pituitary gland Via American Journal of Otolaryngology Publication date: November–December 2021 Source: American Journal of Otolaryngology, Volume 42, Issue 6 Author(s): Mina Zaky, Rebecca A. Compton, Ipek Alpertunga, Arthur S. Tischler, Jeremiah C. Tracy View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Giant Cutaneous Horn: Is It a Tip of An Iceberg? Two Case Reports and a Review of Literature

xlomafota13 shared this article with you from Inoreader Giant Cutaneous Horn: Is It a Tip of An Iceberg? Two Case Reports and a Review of Literature Via Otolaryngology Indian Abstract Cutaneous horns are uncommon lesions which consist of proliferation of keratotic material resembling that of an animal horn. This lesion most commonly occurs in sun-exposed areas, particularly the face, ear, nose, forearms and dorsum of hands. The purpose of the study was to highlight the atypical presentation of squamous cell carcinoma as a giant cutaneous horn along with the review of literature. Case details were obtained from hospital records and clinical and histopathological findings were noted. Herein we report two cases of giant cutaneous horn associated with an underlying carcinoma presenting at an uncommon site. Both the patients were adults and had a chronic history of a skin lesion over the affected sites. Wide local excision was performed in both cases and histopathological examination confirmed the diagnosis of a cutaneous horn with a well differentiated squamous cell carcinoma at the base of the horn. Cutaneous horns are commonly associated with benign lesions and rarely with malignant conditions. It is imperative to biopsy the base of the horn to rule out any underlying malignancy. Proper surgical excision with adequate margins is the preferred treatment in case of an underlying malignancy. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Prevalence of Olfactory and Gustatory Dysfunction in Coronavirus Disease (COVID-19): A Cross Sectional Study in Our Tertiary Care Hospital

xlomafota13 shared this article with you from Inoreader Prevalence of Olfactory and Gustatory Dysfunction in Coronavirus Disease (COVID-19): A Cross Sectional Study in Our Tertiary Care Hospital Via Otolaryngology Indian Abstract COVID-19 pandemic is affecting millions of people all across the globe. Along with other clinical features, anosmia and dysgeusia are important symptoms being seen. This study evaluates the prevalence of olfactory and gustatory dysfunction in patients with SARS CoV-2 infection in a tertiary care centre and the severity and duration of altered taste and smell sensation in COVID positive patients. A total number of 167 patients that had tested positive for COVID 19 KLES Dr. Prabhakar Kore hospital in the study period of 3 months were assessed for presence and severity of olfactory and gustatory sensations. The prevalence of alteration of sense in COVID 19 patients in our tertiary care centre was found to be 62.87% and alteration of taste was 58.68%. This study shows that smell and taste loss has a high prevalence in patients of COVID 19 and health care workers should keep high degree of suspicion for COVID 19 when patients present with these symptoms. The earl y identification may help to reduce the risk of spread. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cause and Management of Suture-related Ocular Complications after Buried-suture Double-eyelid Blepharoplasty

xlomafota13 shared this article with you from Inoreader Cause and Management of Suture-related Ocular Complications after Buried-suture Double-eyelid Blepharoplasty Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Jun 7:S1748-6815(21)00294-1. doi: 10.1016/j.bjps.2021.05.042. Online ahead of print. ABSTRACT BACKGROUND: Buried-suture double-eyelid blepharoplasty is very popular in Asia, especially in China, but there are few reports related to the cause, management, and prevention of suture-related complications of corneal injury and other damages to the eye. The study aims to determine the cause, management, and prevention of suture-related complications after buried-suture double-eyelid blepharoplasty. METHODS: A retrospective study was conducted from January 2016 to January 2019 on 12 patients with corneal and other injuries to the eye after they underwent buried-suture double-eyelid blepharoplasty. The study included patients who underwent intermittent and continuous buried-suture double-eyelid blepharoplasty with the following symptoms: red eye, foreign body sensation, photophobia, pain, tears, and de creased vision. The clinical characteristics, examination method, and treatment were noted. RESULTS: The patients were all females. Ocular injuries included: corneal epithelial punctate or diffuse injury in nine patients, corneal ulcer in two patients, and a perforating eye injury in one patient. The corneal injury was repaired after exposed nylon thread ends were removed. A suture on the surface of the eye penetrating the sclera was detected in one patient, who then had a vitrectomy caused by endophthalmitis. CONCLUSION: Suture-removal surgery is indicated to treat suture-related complications. Less experienced clinicians should use an eyelid protection plate to protect the cornea and eyeball during surgery. The conjunctiva of the fornix should be examined after surgery. The clinician should inquire about the operation history in detail and check the conjunctiva of the fornix with an eyelid retractor to avoid misdiagnosis. PMID:34226132 | DOI:10.1016/j.bjps.2021.05.042 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Aesthetic reconstruction for syndactyly using the 'gradation skin graft' from the plantar instep area

xlomafota13 shared this article with you from Inoreader Aesthetic reconstruction for syndactyly using the "gradation skin graft" from the plantar instep area Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Jun 6:S1748-6815(21)00264-3. doi: 10.1016/j.bjps.2021.05.012. Online ahead of print. ABSTRACT In syndactyly, the donor site of the skin graft should have the characteristics of both the dorsal and the plantar or palmar skin because the skin defects after the dividing procedure are at the lateral sides of the digits. The plantar instep region has a color and texture border between the dorsal and plantar skin as a gradational boundary belt. We performed "gradation skin grafting" including the belt for syndactyly. We retrospectively analyzed 110 skin graft sites in 56 patients, aged ≤ 2 years, with syndactyly of the hand or foot. The follow-up durations were ≥ 6 months. The skin graft sites were divided into the gradation skin graft (G[+]) and the traditional skin graft (G[-]) groups. They were examined for matching of the skin graft with the circumferential skin, the causes of mismatching, the clos ing method of the donor site, and the complications. Regarding skin graft matching, the excellent rate of achievement was greater in the G(+) than in the G(-) group (P < 0.01). The causes of mismatching were misalignment of the gradational boundary belt in the G(+) group and postoperative pigmentation in the G(-) group. All the donor sites were closed directly without complications. The gradation skin graft for syndactyly was cosmetically superior to the traditional one from the submalleolar area. The design's hazard is that the gradational boundary belt of the skin graft should match the alignment with the gradational boundary belt around the skin defect of the digits. PMID:34226133 | DOI:10.1016/j.bjps.2021.05.012 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Abdominoplasty complications - what additional risks do postbariatric patients carry?

xlomafota13 shared this article with you from Inoreader Abdominoplasty complications - what additional risks do postbariatric patients carry? Via Journal of plastic, reconstructive & aesthetic surgery : JPRAS J Plast Reconstr Aesthet Surg. 2021 Jun 6:S1748-6815(21)00270-9. doi: 10.1016/j.bjps.2021.05.018. Online ahead of print. ABSTRACT PURPOSE: Particular trends of postoperative complications following abdominoplasty are seen when patients present with a history of bariatric surgery. This study aims to analyze the risk factors for complications following abdominoplasty among those who did and did not undergo prior bariatric weight loss surgery. METHOD: Data of 144 patients who underwent abdominoplasty at our institution between 2009 and 2015 were reviewed. Prevalence of existing comorbidities and incidences of postoperative complications were recorded, and statistical analysis was carried out to establish differences between our cohorts. RESULTS: Of 144 patients, 49 patients had prior bariatric surgery and 95 patients did not undergo surgery. There was no statistically significant difference between the groups for the prevalenc e of diabetes mellitus, coronary artery disease, hypertension, and anemia, although differences did exist for hypothyroidism and smoking history (p = 0.04 and 0.037, respectively). Postbariatric patients had more comorbidities than nonbariatric patients (p = 0.024). Postoperatively, there was no statistically significant difference between the groups for incidences of hematoma, necrosis, active bleeding, and symptomatic decrease in Hb, although differences did exist for infection (OR = 13.12), seroma (OR = 9.07), prolonged healing (OR = 5.28), and abundant drain secretions (OR = 5.24). Male gender and prior bariatric surgery were associated with higher overall rates of postoperative complications. CONCLUSIONS: Our findings validate the results of prior studies that report a higher prevalence of underlying comorbidities and postoperative complications among postbariatric surgery patients undergoing abdominoplasty. Furthermore, prior bariatric surgery was found to be an independ ent risk factor for the presence of any (OR 4.78 and p < 0.001) and major (OR 4.050 and p = 0.018) complications after abdominoplasty. PMID:34226131 | DOI:10.1016/j.bjps.2021.05.018 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Self-Esteem in Rhinoplasty Patients: A Comparative Study

xlomafota13 shared this article with you from Inoreader Self-Esteem in Rhinoplasty Patients: A Comparative Study Via Otolaryngology Indian Abstract Self-esteem is one of the most important psychological aspect of cosmetic surgery, in our case aesthetic rhinoplasty surgery. Self-esteem can be described as one's attitude towards ownself. Our aim is to assess the self-esteem pre-operatively in patients seeking aesthetic rhinoplasty with respect to those seeking functional rhinoplasty and also compare the post-operative improvement in the self-esteem in those patients. This is a Prospective comparative study in a Tertiary care centre. A total of 48 patients who were planned to undergo rhinoplasty over a period of 1 year in a tertiary care centre, A total of 48 patients (24 requiring aesthetic rhinoplasty and the rest functional rhinoplasty),grouped according to their primary objective, were asked to fill up Rosenberg's self-esteem scale pre-operatively and 6 months post-operatively. Independent t test was used for data analysis. The mean value of self-esteem in aestheti c rhinoplasty group was significantly lower as compared to functional rhinoplasty and there was also significant improvement of self-esteem score post -operatively in the aesthetic rhinoplasty group. Age,gender, marital status, socio-economic status and educational backgrounds were analyzed and there was no significant differences in these factors on comparison between the two groups. Our study showed that self-esteem is an important parameter in cosmetic surgery as patients opting for aesthetic rhinoplasty had lower self-esteem score pre-operatively and there was significant improvement of these scores post-operatively. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The Efficacy of Tracheotomy for Covid-19 Pneumonia: Impacts on Survival and Prognostic Factors

xlomafota13 shared this article with you from Inoreader The Efficacy of Tracheotomy for Covid-19 Pneumonia: Impacts on Survival and Prognostic Factors Via Otolaryngology Indian Abstract The role of tracheotomy during the pandemic remains to be determined for severe COVID-19 pneumonia. We evaluated the effect of tracheotomy on prognostic markers and assessed 4 weeks survival in terms of clinical and biochemical characteristics of patients and time and type (open or percutaneous) of the operation. We performed a retrospective study considering ICU patients with COVID-19 pneumonia and tracheotomy, between May 30 and December 31, 2020. Four weeks survival postoperatively and alteration of biochemical markers were analyzed. 24 patients with COVID-19 pneumonia and tracheotomy, included in this study. Median age was 68.3 years (range 38–90) with male:female ratio 16:8. All the patients were diagnosed with COVID-19 pneumonia considering clinical symptoms and COVID-19 specific CT findings. RT-PCR test results were positive in 58.3%. Prognostic markers were found to be increased postoperatively with both types of surgery (75%). 1 week and 4 weeks survival after the operation was 66.7% and 45.8%, respectively. 4 weeks survival was decreased significantly with NLR ≥ 10 compared to NLR < 10 (15.3–81.8%). Nevertheless, 4 weeks survival differences between males and females (12.5% and 62.5%) and between age ≤ 50 and > 50 (100% and 35%) were also found to be statistically significant. Patients with younger age, male gender, and NLR < 10, were found to have longer survival after tracheotomy. Positive PCR results and preoperative critically increased biochemical markers were related to decreased survival. The number of comorbidities, time and type of surgery, and postoperative increment of prognostic markers seemed not to affect survival. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Using 320-detector row computed tomography angiography to investigate the arterial anatomy of the toe flaps on living humans

xlomafota13 shared this article with you from Inoreader Using 320-detector row computed tomography angiography to investigate the arterial anatomy of the toe flaps on living humans Via radiol anat Surg Radiol Anat. 2021 Jul 5. doi: 10.1007/s00276-021-02793-8. Online ahead of print. ABSTRACT PURPOSE: Using 320-detector row computed tomography angiography (320-CTA) to investigate the arterial supply for the toe flaps, namely the anatomical characteristics of the dorsalis pedis artery (DPA), the first dorsal metatarsal artery (FDMA), and the arteries of the first toe web space (AsFTWS). METHODS: This was a prospective study on CTA of 72 intact feet of 36 Vietnamese adults who had sequelae of thumb or metacarpal hand amputation, from June 2017 to December 2019, then preoperative CTA images were compared with surgical findings on 31 feet of 29 patients. RESULTS: 320-CTA was able to investigate the DPA, FDMA, and AsFTWS in 100% of cases. DPA was absent in 6.9% of cases. The average diameters at its origin and termination were 3.22 and 2.56 mm, respectively. For FDMA, the rates of Gilbert type I, II, and III were 52.8%, 18.1%, and 29.2%; the average diameters at its origin and termination were 1.98 and 1.67 mm, respectively. At the first toe web space, FDMA was dominant in 54.2% of cases; the first plantar metatarsal artery (FPMA) was dominant in 29.2% of cases; both arteries were equally dominant in 16.6%. The average diameter at the origin of the lateral plantar digital artery of the great toe was 1.48 mm, of the medial plantar digital artery of the second toe was 1.21 mm. Preoperative CTA images resembled the surgical findings in all cas es. The survival rate of toe flaps was 100%. CONCLUSION: The 320-CTA provided proper preoperative images in two and three dimensions, and helped surgeons to establish a preoperative surgical plan, thus increasing the success rate of toe transfer surgery. PMID:34226966 | DOI:10.1007/s00276-021-02793-8 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.