Human papillomavirus and induction chemotherapy versus concurrent chemoradiotherapy in locally advanced oropharyngeal cancer: The Dana Farber Experience.

Human papillomavirus and induction chemotherapy versus concurrent chemoradiotherapy in locally advanced oropharyngeal cancer: The Dana Farber Experience.

Head Neck. 2015 Nov 28;

Authors: Lorch JH, Hanna GJ, Posner MR, O'Neill A, Thotakura VL, Limaye SA, Rabinowits G, Sher DJ, Tischler RB, Haddad RI

Abstract
BACKGROUND: Human papillomavirus (HPV) infection indicates favorable prognosis in oropharyngeal squamous cell carcinoma (SCC). The purpose of this study was for us to assess the impact of HPV in patients treated with sequential therapy versus concomitant chemoradiotherapy (CRT).
METHODS: Patients with stage III and IVA and B oropharyngeal SCC were reviewed spanning 10 years.
RESULTS: Among 500 cases, 291 (58%) received CRT versus 209 (42%) sequential therapy. HPV status was known in 279 of patients (56%) and positive in 77% (determined by polymerase chain reaction [PCR; 91%], p16 immunohistochemical [IHC], or both). Median follow-up was 2.8 years. Overall survival (OS) did not differ for sequential therapy versus CRT overall (hazard ratio [HR] = 0.90; p = .66; 3-year OS = 86% and 87%) or within HPV-positive patients (HR = 0.89; p = .81; 3-year OS = 91% and 91%) or within HPV-negative patients (HR = 0.55; p = .32; 3-year OS = 85% and 75%).
CONCLUSION: Survival for all patients was high and notable for HPV-negative patients treated with sequential therapy. Further studies in this patient population are warranted. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26614576 [PubMed - as supplied by publisher]

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Quality assessment in head and neck oncologic surgery in a Brazilian cancer center compared with MD Anderson Cancer Center benchmarks.

Quality assessment in head and neck oncologic surgery in a Brazilian cancer center compared with MD Anderson Cancer Center benchmarks.

Head Neck. 2015 Nov 28;

Authors: Lira RB, de Carvalho AY, de Carvalho GB, Lewis CM, Weber RS, Kowalski LP

Abstract
BACKGROUND: Quality assessment is a major tool for evaluation of health care delivery. In head and neck surgery, the University of Texas MD Anderson Cancer Center (MD Anderson) has defined quality standards by publishing benchmarks.
METHODS: We conducted an analysis of 360 head and neck surgeries performed at the AC Camargo Cancer Center (AC Camargo). The procedures were stratified into low-acuity procedures (LAPs) or high-acuity procedures (HAPs) and outcome indicators where compared to MD Anderson benchmarks.
RESULTS: In the 360 cases, there were 332 LAPs (92.2%) and 28 HAPs (7.8%). Patients with any comorbid condition had a higher incidence of negative outcome indicators (p = .005). In the LAPs, we achieved the MD Anderson benchmarks in all outcome indicators. In HAPs, the rate of surgical site infection and length of hospital stay were higher than what is established by the benchmarks.
CONCLUSION: Quality assessment of head and neck surgery is possible and should be disseminated, improving effectiveness in health care delivery. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26614545 [PubMed - as supplied by publisher]

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Management of the cervico-petrous internal carotid artery in class C tympanojugular paragangliomas.

Management of the cervico-petrous internal carotid artery in class C tympanojugular paragangliomas.

Head Neck. 2015 Nov 28;

Authors: Bacciu A, Prasad SC, Sist N, Rossi G, Piazza P, Sanna M

Abstract
BACKGROUND: Management of the cervical and petrous internal carotid artery (ICA) is frequently required in Fisch class C tympanojugular paragangliomas (TJPs). The purpose of this study was to discuss the perioperative intervention of the ICA in patients who underwent surgical resection of a TJP.
METHODS: A retrospective study of 237 patients surgically treated for Fisch class C TJPs was done to identify cases that required ICA management.
RESULTS: Management of the ICA was required in 176 patients (74.2%). Forty-two patients required just an ICA decompression, 88 underwent a subperiosteal dissection, 19 underwent subadventitial dissection without intraluminal stenting, 17 underwent subadventitial dissection with intraluminal stenting, and 12 underwent arterial resection after permanent balloon occlusion. There were no complications associated with the endovascular procedures. Gross total tumor resection was achieved in 91.5% of the cases.
CONCLUSION: Preoperative endovascular intervention, in selected cases, facilitates gross total tumor removal and significantly reduces the risk of an intraoperative ICA injury. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26614405 [PubMed - as supplied by publisher]

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Pretreatment serum xanthophyll concentrations as predictors of head and neck cancer recurrence and survival.

Pretreatment serum xanthophyll concentrations as predictors of head and neck cancer recurrence and survival.

Head Neck. 2015 Nov 28;

Authors: Arthur AE, Bellile EL, Rozek LS, Peterson KE, Ren J, Harris E, Mueller C, Jolly S, Peterson LA, Wolf GT, Djuric Z

Abstract
BACKGROUND: The purpose of this study was to examine associations of pretreatment serum carotenoids, tocopherols, and quercetin with prognosis in 154 patients newly diagnosed with head and neck cancer.
METHODS: Pretreatment blood and health surveys were collected. Serum micronutrients were measured by high performance liquid chromatography. Data on recurrence and death were collected annually. Cox proportional hazards models measured associations of serum nutrient concentrations with recurrence and overall survival.
RESULTS: During a median follow-up time of 37 months, there were 32 recurrences and 27 deaths. After controlling for covariates, subjects with high versus low serum xanthophyll and total carotenoid concentrations had significantly longer recurrence-free time (p = .002 and p = .02, respectively). Overall survival time was significantly longer in patients with high versus low serum xanthophyll concentrations (p = .02).
CONCLUSION: Future research should evaluate the possible benefits of interventions to increase intakes of rich food sources of xanthophylls in this patient population. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26614223 [PubMed - as supplied by publisher]

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Impact of elective neck dissection on the outcome of oral squamous cell carcinomas arising in the maxillary alveolus and hard palate.

Impact of elective neck dissection on the outcome of oral squamous cell carcinomas arising in the maxillary alveolus and hard palate.

Head Neck. 2015 Nov 28;

Authors: Givi B, Eskander A, Awad MI, Kong Q, Montero PH, Palmer FL, Xu W, De Almeida JR, Lee N, O'Sullivan B, Irish JC, Gilbert R, Ganly I, Patel SG, Goldstein DP, Morris LG

Abstract
BACKGROUND: Whether elective lymph neck dissection (ELND) is associated with improved survival in oral squamous cell carcinomas (SCC) of the maxillary alveolus/hard palate is not known.
METHODS: One hundred ninety-nine patients presenting de novo and receiving treatment for clinically node negative SCC of the maxillary alveolus/hard palate at 2 cancer centers between 1985 and 2011 were analyzed.
RESULTS: Forty-two patients (21%) received ELND. Occult nodal metastases were present in 29% of the dissected necks. The ELND group had more T3 to T4 status tumors (62% vs 34%; p < .001) and positive-margin resections (59% vs 38%; p = .019). Patients undergoing ELND experienced lower rates of neck recurrence (6% vs 21%; p = .031), superior 5-year recurrence-free survival (68% vs 45%; p = .026), and overall survival (86% vs 62%; p = .043). ELND was associated with a 2-fold decrease in risk of recurrence in multivariable analysis.
CONCLUSION: ELND was associated with lower rates of recurrence and improved survival in SCC of the maxillary alveolus/hard palate. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26614119 [PubMed - as supplied by publisher]

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Degree of nephrotoxicity after intermediate- or high-dose cisplatin-based chemoradiotherapy in patients with locally advanced head and neck cancer.

Degree of nephrotoxicity after intermediate- or high-dose cisplatin-based chemoradiotherapy in patients with locally advanced head and neck cancer.

Head Neck. 2015 Nov 28;

Authors: Driessen CM, Uijen MJ, van der Graaf WT, van Opstal CC, Kaanders JH, Nijenhuis T, van Herpen CM

Abstract
BACKGROUND: The purpose of this study was to compare the occurrence of cisplatin-induced nephrotoxicity between concomitant chemoradiotherapy with high versus intermediate-dose cisplatin.
METHODS: One hundred forty-four patients with locally advanced head and neck or nasopharyngeal cancer (NPC) were included; 40 patients received cisplatin 100 mg/m(2) (high dose) on days 1, 22, and 43, and 104 patients received cisplatin 40 mg/m(2) weekly (intermediate dose) during 6 weeks in combination with radiotherapy.
RESULTS: During treatment with intermediate-dose cisplatin, 6.7% developed an increase of ≥50% serum creatinine versus 60.0% treated with high-dose cisplatin (p < .05). Nephrotoxicity (all grades) scored by Common Toxicity Criteria for Adverse Events (CTCAE) version 3.0 or CTCAE version 4.03 was 53% and 100% in the high-dose group and 4.8% and 68% in the intermediate-dose group, respectively.
CONCLUSION: Significantly less nephrotoxicity occurs during chemoradiotherapy with intermediate-dose cisplatin compared with high-dose cisplatin. The CTCAE version 4.03 seems to be more appropriate in scoring nephrotoxicity than the CTCAE version 3.0. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26614010 [PubMed - as supplied by publisher]

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Adjuvant radiotherapy for early head and neck squamous cell carcinoma with perineural invasion: A systematic review.

Adjuvant radiotherapy for early head and neck squamous cell carcinoma with perineural invasion: A systematic review.

Head Neck. 2015 Nov 28;

Authors: Bur AM, Lin A, Weinstein GS

Abstract
Perineural invasion (PNI) is widely regarded as a negative prognostic factor in head and neck squamous cell carcinoma (HNSCC). Treatment guidelines recommend adjuvant radiotherapy (RT) for patients with adverse pathologic features, including PNI. The purpose of this study was to systematically review the literature to determine if patients with PNI as their only indication for adjuvant therapy benefit from adjuvant RT. In total, 339 abstracts were reviewed for relevance leaving 85 articles, which were evaluated in detail. Thirteen retrospective studies addressed the role of adjuvant RT for patients with PNI. Evidence is lacking to recommend adjuvant RT for all patients with HNSCC with PNI. However, the literature suggests that large nerve or multifocal PNI may predict worse outcome and may be a more appropriate indication for adjuvant therapy. We advocate that patients decide whether to undergo adjuvant therapy after a discussion of the limitations of current evidence. © 2015 Wiley Periodicals, Inc. Head Neck 00: 000-000, 2015.

PMID: 26613965 [PubMed - as supplied by publisher]

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Recent advances in optical diagnosis of oral cancers: Review and future perspectives.

Recent advances in optical diagnosis of oral cancers: Review and future perspectives.

Head Neck. 2015 Nov 28;

Authors: Singh SP, Ibrahim O, Byrne HJ, Mikkonen JW, Koistinen AP, Kullaa AM, Lyng FM

Abstract
Optical diagnosis techniques offer several advantages over traditional approaches, including objectivity, speed, and cost, and these label-free, noninvasive methods have the potential to change the future workflow of cancer management. The oral cavity is particularly accessible and, thus, such methods may serve as alternate/adjunct tools to traditional methods. Recently, in vivo human clinical studies have been initiated with a view to clinical translation of such technologies. A comprehensive review of optical methods in oral cancer diagnosis is presented. After an introduction to the epidemiology and etiological factors associated with oral cancers currently used, diagnostic methods and their limitations are presented. A thorough review of fluorescence, infrared absorption, and Raman spectroscopic methods in oral cancer diagnosis is presented. The applicability of minimally invasive methods based on serum/saliva is also discussed. The review concludes with a discussion on future demands and scope of developments from a clinical point of view. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26613806 [PubMed - as supplied by publisher]

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Treatment of squamous cell carcinoma of the posterior pharyngeal wall: Radiotherapy versus surgery.

Treatment of squamous cell carcinoma of the posterior pharyngeal wall: Radiotherapy versus surgery.

Head Neck. 2015 Nov 28;

Authors: De Felice F, Blanchard P, Levy A, Nguyen F, Gorphe P, Janot F, Temam S, Tao Y

Abstract
BACKGROUND: Treatment strategy in squamous cell carcinoma (SCC) of the posterior pharyngeal wall is still being debated.
METHODS: We performed a retrospective analysis according to delivered treatment.
RESULTS: One hundred eighty patients were treated between 1997 and 2011. Eighty-nine patients (49.4%) received surgery +/- radiotherapy (RT), whereas 91 (50.6%) received definitive RT +/- chemoradiotherapy (RT/CRT). Five-year overall survival (OS) was 33.4%. There was a significant 5-year OS benefit in surgical treatment versus RT/CRT (43% vs 24.1%; p = .002). Multivariate analysis showed that current smokers, T3 to T4 classification, well-differentiated SCC, and nonsurgical treatment were associated with reduced OS. Subgroup analysis showed significant survival benefit of surgical treatment compared with RT/CRT in patients with T1 to T2 but not in T3 to T4 disease.
CONCLUSION: Surgical management translated into a survival benefit, even in early T classification. These results should be interpreted with caution for selection bias. Surgery remains the standard of care in localized posterior pharyngeal wall SCC. Primary CRT should be considered for nonoperable disease. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26613802 [PubMed - as supplied by publisher]

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Psychometric evaluation of the Swallowing Outcomes After Laryngectomy (SOAL) patient-reported outcome measure.

Psychometric evaluation of the Swallowing Outcomes After Laryngectomy (SOAL) patient-reported outcome measure.

Head Neck. 2015 Nov 28;

Authors: Govender R, Lee MT, Drinnan M, Davies T, Twinn C, Hilari K

Abstract
BACKGROUND: The purpose of this study was to evaluate the psychometric properties of the Swallowing Outcomes After Laryngectomy (SOAL) in a large group of people who underwent a laryngectomy.
METHODS: We conducted a cross-sectional psychometric study of laryngectomy patients (minimum 3 months posttreatment) attending routine hospital follow-up for the psychometric evaluation of SOAL.
RESULTS: One hundred ten people participated in this study. Thirteen percent of the patients had a laryngectomy, 63% had laryngectomy with radiotherapy, and 24% had laryngectomy with chemoradiation therapy. The SOAL showed good quality of data (minimal missing data and floor effects); good internal consistency (α = 0.91); and adequate test-retest reliability (intra-class correlation coefficient = 0.73). In terms of validity, it differentiated people by treatment group (F(2,85) = 8.02; p = .001) and diet texture group (t(102) = -7.33; p < .001).
CONCLUSION: The SOAL demonstrates good validity and has potential for use in research. Further study is required to determine its clinical application. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26613682 [PubMed - as supplied by publisher]

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Influence of social factors on patient-reported late symptoms: Report from a controlled trial among long-term head and neck cancer survivors in Denmark.

Influence of social factors on patient-reported late symptoms: Report from a controlled trial among long-term head and neck cancer survivors in Denmark.

Head Neck. 2015 Nov 28;

Authors: Kjaer TK, Johansen C, Andersen E, Karlsen R, Nielsen AL, Frederiksen K, Rørth M, Ibfelt E, Dalton SO

Abstract
BACKGROUND: The incidence of head and neck cancer and morbidity and mortality after treatment are associated with social factors. Whether social factors also play a role in the prevalence of late-onset symptoms after treatment for head and neck cancer is not clear.
METHODS: Three hundred sixty-nine survivors completed questionnaires on late symptoms and functioning.
RESULTS: Survivors with short education were more likely to report severe problems than those with medium or long education. In the fully adjusted model, the risk for problems with opening the mouth remained significantly increased (odds ratio [OR] = 3.20; 95% confidence interval [CI] = 1.18-8.63). For survivors who lived alone, the adjusted ORs were significantly increased for physical functioning (2.17; 95% CI = 1.01-4.68) and trouble with social eating (OR = 2.26; 95% CI = 1.14-4.47).
CONCLUSION: Self-reported severe late symptoms were more prevalent in survivors with short education and in those living alone, suggesting differences in perception of late symptoms between social groups. © 2015 Wiley Periodicals, Inc. Head Neck, 2015.

PMID: 26613661 [PubMed - as supplied by publisher]

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Comprehensive Postoperative Management After Endoscopic Skull Base Surgery.

Comprehensive Postoperative Management After Endoscopic Skull Base Surgery.

Otolaryngol Clin North Am. 2016 Feb;49(1):253-263

Authors: Tien DA, Stokken JK, Recinos PF, Woodard TD, Sindwani R

Abstract
To maximize outcomes from endoscopic skull base surgery, careful early postoperative management is critically important. Standardized postoperative regimens are lacking. The type of reconstruction and presence and type of cerebrospinal fluid leak dictate management. If a leak is encountered intraoperatively, patients should avoid maneuvers that increase intracranial pressures for at least 1 month. Early postoperative care focuses on minimizing and managing nasal crusting. This article reviews the evidence in the literature on postoperative management, complications, and quality of life after surgery, and outlines our experience in the management of patients after endoscopic skull base surgery.

PMID: 26614842 [PubMed - as supplied by publisher]

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Cerebrospinal Fluid Diversion in Endoscopic Skull Base Reconstruction: An Evidence-Based Approach to the Use of Lumbar Drains.

Cerebrospinal Fluid Diversion in Endoscopic Skull Base Reconstruction: An Evidence-Based Approach to the Use of Lumbar Drains.

Otolaryngol Clin North Am. 2016 Feb;49(1):119-129

Authors: Tien DA, Stokken JK, Recinos PF, Woodard TD, Sindwani R

Abstract
Before the vascularized pedicled nasoseptal flap was popularized, lumbar drains (LDs) were routinely used for cerebral spinal fluid (CSF) diversion in endoscopic skull base reconstruction. LDs are not necessary in most CSF leaks encountered during skull base surgery. In this article, the use is considered of an LD in select high-risk settings in which a high-flow leak is anticipated and the patient has significant risk factors that make closure of the leak more challenging. Evidence for the use of LDs in preventing postoperative after endoscopic skull base reconstruction is reviewed and a rational framework for their use is proposed.

PMID: 26614832 [PubMed - as supplied by publisher]

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A software tool for pure‑tone audiometry : Classification of audiograms for inclusion of patients in clinical trials. English version.

A software tool for pure‑tone audiometry : Classification of audiograms for inclusion of patients in clinical trials. English version.

HNO. 2015 Nov 25;

Authors: Rahne T, Buthut F, Plößl S, Plontke SK

Abstract
OBJECTIVE: Selecting subjects for clinical trials on hearing loss therapies relies on the patient meeting the audiological inclusion criteria. In studies on the treatment of idiopathic sudden sensorineural hearing loss, the patient's acute audiogram is usually compared with a previous audiogram, the audiogram of the non-affected ear, or a normal audiogram according to an ISO standard. Generally, many more patients are screened than actually fulfill the particular inclusion criteria. The inclusion criteria often require a calculation of pure-tone averages, selection of the most affected frequencies, and calculation of hearing loss differences.
MATERIALS AND METHODS: A software tool was developed to simplify and accelerate this inclusion procedure for investigators to estimate the possible recruitment rate during the planning phase of a clinical trial and during the actual study. This tool is Microsoft Excel-based and easy to modify to meet the particular inclusion criteria of a specific clinical trial. The tool was retrospectively evaluated on 100 patients with acute hearing loss comparing the times for classifying automatically and manually. The study sample comprised 100 patients with idiopathic sudden sensorineural hearing loss.
RESULTS AND CONCLUSION: The age- and sex-related normative audiogram was calculated automatically by the tool and the hearing impairment was graded. The estimated recruitment rate of our sample was quickly calculated. Information about meeting the inclusion criteria was provided instantaneously. A significant reduction of 30 % in the time required for classifying (30 s per patient) was observed.

PMID: 26607156 [PubMed - as supplied by publisher]

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[A software tool for pure-tone audiometry : Classification of audiograms for inclusion of patients in clinical trials. German version].

[A software tool for pure-tone audiometry : Classification of audiograms for inclusion of patients in clinical trials. German version].

HNO. 2015 Nov 25;

Authors: Rahne T, Buthut F, Plößl S, Plontke SK

Abstract
OBJECTIVE: Selecting subjects for clinical trials on hearing loss therapies relies on the patient meeting the audiological inclusion criteria. In studies on the treatment of idiopathic sudden sensorineural hearing loss, the patient's acute audiogram is usually compared with a previous audiogram, the audiogram of the non-affected ear, or a normal audiogram according to an ISO standard. Generally, many more patients are screened than actually fulfill the particular inclusion criteria. The inclusion criteria often require a calculation of pure-tone averages, selection of the most affected frequencies, and calculation of hearing loss differences.
MATERIALS AND METHODS: A software tool was developed to simplify and accelerate this inclusion procedure for investigators to estimate the possible recruitment rate during the planning phase of a clinical trial and during the actual study. This tool is Microsoft Excel-based and easy to modify to meet the particular inclusion criteria of a specific clinical trial. The tool was retrospectively evaluated on 100 patients with acute hearing loss comparing the times for classifying automatically and manually. The study sample comprised 100 patients with idiopathic sudden sensorineural hearing loss.
RESULTS AND CONCLUSION: The age- and sex-related normative audiogram was calculated automatically by the tool and the hearing impairment was graded. The estimated recruitment rate of our sample was quickly calculated. Information about meeting the inclusion criteria was provided instantaneously. A significant reduction of 30 % in the time required for classifying (30 s per patient) was observed.

PMID: 26607155 [PubMed - as supplied by publisher]

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Medicine,New Articles,November 27th,2015

Management of poor-risk metastatic renal cell carcinoma: current approaches, the role of temsirolimus and future directions

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Future Oncology Ahead of Print. from Cancer via ola Kala on Inoreader http://ift.tt/1lkGUDB via IFTTT

Dosimetric analysis of the alopecia preventing effect of hippocampus sparing whole brain radiation therapy

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract Background Whole brain radiation therapy (WBRT) is widely used for the treatment of brain metastases. Cognitive decline and alopecia are recognized adverse effects of WBRT. Recently hippocampus sparing whole brain radiation therapy (HS-WBRT) has been shown to reduce the incidence of memory loss. In this study, we found that multi-field intensity modulated radiation therapy (IMRT), with strict constraints to the brain parenchyma and to the hippocampus, reduces follicular scalp dose and prevents alopecia. Methods Suitable patients befitting the inclusion criteria of the RTO...περισσότερα »

Prognostic indices in stereotactic radiotherapy of brain metastases of non-small cell lung cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract Background Our purpose was to analyze the long-term clinical outcome and to identify prognostic factors after Linac-based stereotactic radiosurgery (SRS) or fractionated stereotactic radiotherapy (FSRT) on patients with brain metastases (BM) from non-small cell lung cancer (NSCLC). Materials and Methods We performed a retrospective analysis of survival on 90 patients who underwent SRS or FSRT of intracranial NSCLC metastases between 04/2004 and 05/2014 that had not undergone prior surgery or whole brain radiotherapy (WBRT) for BM. Follow-up data was analyzed until May 201... περισσότερα »

A prospective study of nomogram-based adaptation of prostate radiotherapy target volumes

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract Background A prospective clinical trial was conducted to evaluate the feasibility of a novel approach to the treatment of patients with high risk prostate cancer (HRPC) through the use of a nomogram to tailor radiotherapy target volumes. Methods Twenty seven subjects with HRPC were treated with a mildly hypofractionated radiotherapy regimen using image-guided IMRT technique between Jun/2013-Jan/2015. A set of validated prognostic factors were inputted into the Memorial-Sloan-Kettering Cancer Center (MSKCC) prostate cancer nomogram to estimate risk of loco-regional spread...περισσότερα »

Non-invasive molecular imaging of inflammatory macrophages in allograft rejection

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract Background Macrophages represent a critical cell type in host defense, development and homeostasis. The ability to image non-invasively pro-inflammatory macrophage infiltrate into a transplanted organ may provide an additional tool for the monitoring of the immune response of the recipient against the donor graft. We therefore decided to image in vivo sialoadhesin (Sn, Siglec 1 or CD169) using anti-Sn mAb (SER-4) directly radiolabelled with 99mTc pertechnetate. Methods We used a heterotopic heart transplantation model where allogeneic or syngeneic heart grafts were trans... περισσότερα »

The Multidisciplinary Management of Cancer in Daily Clinical Practice: Towards a Community Hospital Comprehensive Cancer Center

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

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hcrcn81 promotes cell proliferation through Wnt signaling pathway in colorectal cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract The objective of the study was to investigate the role of hcrcn81 gene in Wnt/β-catenin signaling pathway related to human colorectal cancer. A total of 30 pairs of human colorectal cancer tissues with control normal tissues were analyzed by qRT-PCR. The proliferation, apoptosis, cell cycle, cell colony and metastasis of LS174T−hcrcn81, HCT116−hcrcn81, LoVo+hcrcn81 and SMMC-7721+hcrcn81 cells were tested, of which hcrcn81 was knockdown in LS174T, HCT116 cells and hcrcn81 was overexpressed in LoVo, SMMC-7721 cells. Besides, the mRNA and protein levels of hcrcn81, β-catenin,...περισσότερα »

Cardiovascular medication after cancer at a young age in Finland: A nationwide registry linkage study

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract Despite improved survival rates, childhood and young adult (YA) cancer survivors face elevated risks for life-threatening morbidities, especially cardiovascular complications. Our nationwide Finnish registry study investigated the purchases of cardiovascular medication from 1993 to 2011 in patients diagnosed with cancer aged below 35 years (N=8,197) between 1993 and 2004 compared to siblings (N=29,974) via linkage to the drug purchase registry. The cumulative incidence for purchasing cardiovascular medications was higher in childhood and YA cancer patients compared to sib... περισσότερα »

Decreased expression of BRCA1-associated protein 1 predicts unfavorable survival in gastric adenocarcinoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract BRCA1-associated protein 1 (BAP1) has been reported as a novel tumor suppressor, while in gastric adenocarcinoma, the function of this protein was still await to be uncovered. Based on a large group of patients with gastric adenocarcinoma, our study aimed to have a further understanding about the correlation of BAP1 expression and patients' clinical outcomes. We performed quantitative PCR and Western blot to examine BAP1 expression in 38 cases of gastric adenocarcinoma samples and adjacent non-cancerous tissues. Immunochemistry was used to evaluate BAP1 expression in a lar... περισσότερα »

Downregulation of long noncoding RNA NONHSAT037832 in papillary thyroid carcinoma and its clinical significance

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract Long noncoding RNA (lncRNA) is a kind of RNA that is longer than 200 nucleotides with limited or no protein-coding potential. Studies have proved that lncRNAs play important regulatory roles in gene expression and contribute to oncogenesis and cancer metastasis. However, the expression level of lncRNAs and their clinicopathologic significance in papillary thyroid carcinoma (PTC) have not been well studied. In this study, we investigated the expression level of a novel lncRNA NONHSAT037832 in PTC and paired noncancerous thyroid tissues as well as some cell lines by quantit...περισσότερα »

Expression of chemokine receptor CXCR4 is closely correlated with clinical outcome in human nasopharyngeal carcinoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract The CXC chemokine receptor 4 (CXCR4) has been reported to be involved in the development and progression of nasopharyngeal carcinoma (NPC). However, the role of CXCR4 in clinical outcome and prognosis of NPC patients remains controversial. In the present study, we investigated and reviewed the expression of CXCR4 in NPC tissues and then analyzed the definitive role of CXCR4 in clinical outcome and prognosis. Here, we found that the expression level of CXCR4 was significantly higher in NPC cancer specimens (61/98) than that in paired non-tumor tissues (*p* &lt; 0.001). Togethe...περισσότερα »

Anti-tumor angiogenesis effect of a new compound: B-9-3 through interference with VEGFR2 signaling

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract B-9-3, a derivative of harmine, was first synthesized in our laboratory. We have reported that B-9-3 has an anti-proliferative effect against human lung cancer cells via induction of apoptosis and inhibition of cell migration. In the present study, we first studied that the anti-tumor angiogenesis effect and the molecular mechanism of B-9-3-induced tumor vascular degrade and mortify in lung cancer. In vitro, the results showed that B-9-3 selectively inhibited the proliferation of endothelial cells IC50 = 6.16 μg/ml) and vascular fibroblasts (IC50 = 12.59 μg/ml) and induce... περισσότερα »

The immunobiology of myeloid-derived suppressor cells in cancer

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract The tumor microenvironment is a complex and heterogeneous milieu in which multiple interactions occur between tumor and host cells. Immunosuppressive cells which are present in this microenvironment, such as regulatory T (Treg) cells and myeloid-derived suppressor cells (MDSCs), play an important role in tumor progression, via down-regulation of antitumor responses. MDSCs represent a heterogeneous group of cells originated from the myeloid lineage that are in the immature state. These cells markedly accumulate under pathologic conditions, such as cancer, infection, and in... περισσότερα »

Wnt5a and Ror2 expression associate with the disease progress of primary thyroid lymphoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract Primary thyroid lymphoma (PTL) is a rare malignant thyroid tumor; its pathogenesis is closely related to chronic lymphocytic thyroiditis. The different pathological subtypes and stages of PTL have distinct clinical characteristics and prognosis, but the specific reasons are not clear. Wnt5a is a representative protein of non-canonical Wnt signaling. It plays an important role in many different types of tumors. This study is to explore the changes of Wnt5a and its receptor Ror2 in PTL development process and the clinical significance of their represent. We collected 22 PTL... περισσότερα »

Norcantharidin modulates miR-655-regulated SENP6 protein translation to suppresses invasion of glioblastoma cells

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract Norcantharidin (NCTD) is currently used as an anticancer drug for the treatment of some malignant cancers. However, whether it may have therapeutic effects on glioblastoma multiforme (GBM) remains unknown. Moreover, the underlying mechanisms have not been completely elucidated. Recently, SUMO-specific protease 6 (SENP6) has been shown as a tumor suppressor in some cancers. Nevertheless, whether it is involved in the pathogenesis of GBM has not been examined. Here, we studied the effects of NCTD on GBM cells. We found that NCTD dose-dependently increased SENP6 protein, but... περισσότερα »

Influence of the interaction between long noncoding RNAs and hypoxia on tumorigenesis

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract The interaction between cancer and its microenvironment is crucial for survival and development of cancerous cells. Tumor microenvironment is usually under hypoxia, which promotes tumor aggressiveness like growth, angiogenesis, and metastasis. How cancer cells respond to hypoxia and the resultant impact on tumorigenesis are not yet fully explored. Long noncoding RNAs (lncRNAs) have been attracting more and more attention since their functions in regulating gene expression at chromatic, transcriptional, and posttranscriptional levels were found. lncRNAs are dysregulated in...περισσότερα »

Postoperative permanent pressure alopecia

Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 2 ώρες

Abstract A 49-year-old Chinese female underwent elective laparoscopic assisted Whipple's surgery lasting 12 h. This was complicated by postoperative pressure alopecia at the occipital area of the scalp. Pressure-induced hair loss after general anaesthesia is uncommon and typically temporary, but may be disconcerting to the patient. We report this case of postoperative permanent pressure alopecia due to its rarity in the anaesthesia/local literature, and review the risk factors for its development. from Anaesthesia via ola Kala on Inoreader http://ift.tt/1Nf2tAf via IFTTT

Pediatric anesthesia: current status and future directions

Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 2 ώρες

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Confirmation of tracheal intubation time in adult patients

Alexandros G. SfakianakisστοAnaesthesiologyΠριν από 2 ώρες

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Justicia adhatoda L. (Acanthacées)

Alexandros G. SfakianakisστοΘεραπείαΠριν από 2 ώρες

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Étude ethnobotanique, pharmacologique et phytochimique de quelques plantes médicinales congolaises à potentialité antitussive

Alexandros G. SfakianakisστοΘεραπείαΠριν από 2 ώρες

Résumé Ce travail a permis d'ajouter au répertoire congolais les plantes à potentialités antitussives. L'enquête sur le terrain auprès des personnes ressources nous a permis de recenser 17 plantes dont le *Chenopodium ambrosioides* Lin (Chenoponaceae) et le *Erigeron floribundus* Kunth. qui ont été les plus citées. Les feuilles de *Chenopodium ambrosioides* Lin (Chenoponaceae) et de *Erigeron floribundus* Kunth. (Asteraceae) possèdent une activité antitussive. L'activité de ces plantes a été évaluée chez le cobaye en utilisant le modèle classique d'acide citrique. Le décocté de *Er...περισσότερα »

Phyto-aromathérapie de la bronchite chronique (BPCO)

Alexandros G. SfakianakisστοΘεραπείαΠριν από 2 ώρες

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Complicated Intra-Abdominal Infections: The Old Antimicrobials and the New Players

Alexandros G. SfakianakisστοΘεραπείαΠριν από 2 ώρες

Abstract Complicated intra-abdominal infections (cIAIs) are an important cause of morbidity and mortality worldwide. They are diagnosed when the initial abdominal organ infection has spread into the peritoneal space. Successful treatment relies on adequate source control and appropriate empiric antimicrobial therapy. Inappropriate antimicrobial therapy may result in poor patient outcomes and increases in healthcare costs. Current guidelines recommend several single and combination antimicrobial regimens; however, empiric antimicrobial treatment has been complicated by the increasin... περισσότερα »

Lacosamide: A Review in Focal Seizures in Patients with Epilepsy

Alexandros G. SfakianakisστοΘεραπείαΠριν από 2 ώρες

Abstract Lacosamide (Vimpat®) is a functionalized amino acid available orally (as a solution or tablets) and as an intravenous infusion for use as monotherapy (only in the USA) or adjunctive therapy for the treatment of focal seizures in adult and adolescent (aged ≥17 years in the USA) patients with epilepsy. As adjunctive therapy to other antiepileptic drugs (AEDs), lacosamide provided effective seizure control and was generally well tolerated in adults and adolescents (aged ≥16 years) in randomized clinical trials and in the real-world setting. In clinical trials, adjunctive laco... περισσότερα »

Insulin Aspart in the Management of Diabetes Mellitus: 15 Years of Clinical Experience

Alexandros G. SfakianakisστοΘεραπείαΠριν από 2 ώρες

Abstract Limiting excessive postprandial glucose excursions is an important component of good overall glycemic control in diabetes mellitus. Pharmacokinetic studies have shown that insulin aspart, which is structurally identical to regular human insulin except for the replacement of a single proline amino acid with an aspartic acid residue, has a more physiologic time–action profile (i.e., reaches a higher peak and reaches that peak sooner) than regular human insulin. As expected with this improved pharmacokinetic profile, insulin aspart demonstrates a greater glucose-lowering eff... περισσότερα »

Regulatory effects of ΔFosB on proliferation and apoptosis of MCF-7 breast cancer cells

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract Matrix metalloproteinase-9 (MMP-9) plays a vital role in tumor angiogenesis, cell migration, and invasiveness because it can degrade almost all basement membrane and extracellular matrix components. MMP-9 has been reported in many cancers including breast cancer, lung cancer, and colon cancer. ΔFosB in mammary epithelial cells has been shown to regulate cell proliferation, differentiation, and death. We found that ΔFosB increased the expression of MMP-9 in MCF-7 breast cancer cells. ΔFosB overexpression in MCF-7 cells increased cellular viability and decreased cell apopto...περισσότερα »

CD24 promotes HCC progression via triggering Notch-related EMT and modulation of tumor microenvironment

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract CD24 is known as a cell surface molecule in hematopoiesis and also described as a diagnostic marker for tumors. Previous studies suggested the important role of CD24 in hepatocellular carcinoma (HCC) pathogenesis. However, precise functions of CD24 in HCC are still unknown. Here, we found that CD24 is highly expressed in HCC both in mRNA and protein levels. Further, the epithelial-mesenchymal transition (EMT) and Notch1 signaling activations mediated by CD24 were elucidated as potential mechanisms of HCC promotion in Hepa1-6/Hepa1-6-CD24 cell models. Additionally, possible...περισσότερα »

MPT0B169, a novel tubulin inhibitor, induces apoptosis in taxol-resistant acute myeloid leukemia cells through mitochondrial dysfunction and Mcl-1 downregulation

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract Acute myeloid leukemia (AML) is a hematological malignant disorder. AML cells are not susceptible to chemotherapeutic drugs because of their multidrug resistance (MDR). Antitubulin agents are currently employed in cancer treatments; however, drug resistance results in treatment failures because of MDR1 expressing cancer cells. We previously synthesized a new tubulin inhibitor, 2-dimethylamino-*N*-[1-(4-methoxy-benzenesulfonyl)-2,3-dihydro-1H-indol-7-yl]-acetamide (MPT0B169), which inhibits AML cell proliferation by arresting cell cycle at the G2/M phase. In this study, we ...περισσότερα »

The involvement of anterior gradient 2 in the stromal cell-derived factor 1-induced epithelial-mesenchymal transition of glioblastoma

Alexandros G. SfakianakisστοΟγκολογίαΠριν από 2 ώρες

Abstract In recent years, it has been widely identified that the stromal cell-derived factor 1 (SDF-1) and anterior gradient 2 (AGR2) were implicated in the development of epithelial-mesenchymal transition (EMT) in a variety of cancers. However, the involvement of SDF-1-AGR2 pathway in the EMT of glioblastoma has not been investigated. In the present study, the in vitro assays were used to investigate the role of AGR2 in cell cycle, migration, and invasion. We found that the expressions of AGR2 and chemokine (C-X-C motif) receptor 4 (CXCR4) were obviously upregulated in glioblasto... περισσότερα »

An extra-virgin olive oil rich in polyphenolic compounds has antioxidant effects in meat-type broiler chickens

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες

Abstract The aim of this study was to extend the knowledge on the antioxidant effect of extra-virgin olive oil (EVOO) in the liver of broiler chickens not subjected to any form of insult. A total of 120 male broiler chickens (Hubbard strain) were divided into three groups and fed ad libitum with three isoenergetic diets from hatching until slaughter age (49 days) on a completely randomized design. The dietary treatments consisted of 2.5 % added oil or fat from three sources as follows: diet containing sunflower oil (SFO); diet containing lard (LRD), and diet containing extra-virgin... περισσότερα »

Évaluation d’un protocole de ré-introduction médicamenteuse chez l’enfant

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες

Publication date: December 2015 *Source:*Annales de Dermatologie et de Vénéréologie, Volume 142, Issue 12, Supplement Author(s): A. Baron, A. Pipet, H. Colas, A. Magnan, C. Bernier IntroductionL'étiquette d'allergie médicamenteuse est très souvent posée chez l'enfant présentant une éruption cutanée en contexte infectieux. Le plus souvent, l'origine est virale. L'expérience montre qu'après bilan allergologique [tests cutanés puis test de provocation orale (TPO)], seul un faible pourcentage d'enfants s'avère réellement allergique. Il est donc important d'éliminer rapidement ce diagnos... περισσότερα »

EMMPRIN/CD147 est un biomarqueur pronostique indépendant dans le mélanome cutané

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες

Publication date: December 2015 *Source:*Annales de Dermatologie et de Vénéréologie, Volume 142, Issue 12, Supplement Author(s): A. Caudron, M. Battistella, J.-P. Feugeas, C. Pages, N. Basset-Seguin, A. Sadoux, M.-P. Podgorniak, A. Janin, C. Lebbé, S. Mourah IntroductionEMMPRIN (Extracellular Matrix MetalloPRoteinase INducer) est un membre de la superfamille des immunoglobulines connu pour stimuler la dégradation des composants de la membrane basale en induisant la synthèse des MMPs (métalloproteinases matricielles). Il a été démontré que la protéine EMMPRIN est impliquée dans l'inv... περισσότερα »

Journées dermatologiques de Paris 2015

Alexandros G. SfakianakisστοΑισθητική ΔερματολογίαΠριν από 2 ώρες

Publication date: December 2015 *Source:*Annales de Dermatologie et de Vénéréologie, Volume 142, Issue 12, Supplement Author(s): F. Caux from #Dermatology via alexandrossfakianakis on Inoreader http://ift.tt/1NewgZO via IFTTT

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Alexi ViadisστοHead and Neck Diseases by Alexandros G.SfakianakisΠριν από 4 ώρες

Dear Subscriber, You have successfully unsubscribed from *DG News*. You may still access the site at: http://ift.tt/1XcFKGe. If you believe this is to be an error or would like to be re-subscribed to *DG News*, click here. Please send any feedback to dgnews@docguide.com. from #Med Blogs by Alexandros G.Sfakianakis via paythelady61 on Inoreader http://ift.tt/1MUr49U via IFTTT

Melatonin enhances vertical bone augmentation in rat calvaria secluded spaces.

Melatonin enhances vertical bone augmentation in rat calvaria secluded spaces.

Med Oral Patol Oral Cir Bucal. 2015 Nov 22;:0

Authors: Shino H, Hasuike A, Arai Y, Honda M, Isokawa K, Sato S

Abstract
BACKGROUND: Melatonin has many roles, including bone remodeling and osseointegration of dental implants. The topical application of melatonin facilitated bone regeneration in bone defects. We evaluated the effects of topical application of melatonin on vertical bone augmentation in rat calvaria secluded spaces.
MATERIAL AND METHODS: In total, 12 male Fischer rats were used and two plastic caps were fixed in the calvarium. One plastic cap was filled with melatonin powder and the other was left empty.
RESULTS: Newly generated bone at bone defects and within the plastic caps was evaluated using micro-CT and histological sections. New bone regeneration within the plastic cap was increased significantly in the melatonin versus the control group.
CONCLUSIONS: Melatonin promoted vertical bone regeneration in rat calvaria in the secluded space within the plastic cap.

PMID: 26595835 [PubMed - as supplied by publisher]

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Bacterial inactivation/sterilization by argon plasma treatment on contaminated titanium implant surfaces: In vitro study.

Bacterial inactivation/sterilization by argon plasma treatment on contaminated titanium implant surfaces: In vitro study.

Med Oral Patol Oral Cir Bucal. 2015 Nov 22;:0

Authors: Annunziata M, Canullo L, Donnarumma G, Caputo P, Nastri L, Guida L

Abstract
BACKGROUND: Surface treatment by argon plasma is widely used as the last step of the manufacturing process of titanium implant fixtures before their sterilization by gamma rays. The possibility of using such a technology in the daily clinical practice is particularly fascinating. The aim of the present study was to assess the effects of the argon plasma treatment on different titanium implant surfaces previously exposed in vitro to bacterial contamination.
MATERIAL AND METHODS: Sterile c.p. titanium implant discs with turned (T, Sa: 0.8μm), sandblasted/acid-etched (SAE, Sa: 1.3μm) and titanium plasma sprayed (TPS, Sa: 3.0μm) surface were used in this study. A strain of Aggregatibacter actinomycetemcomitans ATCC3718 was grown at 37°C under anaerobic conditions for 24 h and then transferred on six discs for each of the three surface types. After 24 hours, a half of the contaminated discs (control group) were directly used to evaluate the colony forming units (CFUs). The other half of the contaminated discs (test group) were treated in an argon plasma chamber for 12 minutes at room temperature prior to be analyzed for CFU counting. All assays were performed using triplicate samples of each material in 3 different experiments.
RESULTS: When the CFU counting was carried out on control discs, a total of 1.50x106±1.4x105, 1.55x106±7.07x104 and 3.15x106±2.12x105 CFU was respectively assessed for T, SAE and TPS discs, without statistically significant differences among the three surfaces. On the contrary, any trace of bacterial contamination was assessed for titanium discs treated in the argon plasma chamber prior to be analyzed, irrespectively to the implant surface tested.
CONCLUSIONS: Within the limit of this study, reported data suggested that the argon plasma technology could be efficiently used to decontaminate/sterilize previously infected titanium implant surfaces.

PMID: 26595834 [PubMed - as supplied by publisher]

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The isolated orbital floor fracture from a transconjunctival or subciliary perspective-A standardized anthropometric evaluation.

The isolated orbital floor fracture from a transconjunctival or subciliary perspective-A standardized anthropometric evaluation.

Med Oral Patol Oral Cir Bucal. 2015 Nov 22;:0

Authors: Raschke G, Djedovic G, Peisker A, Wohlrath R, Rieger U, Guentsch A, Gomez-Dammeier M, Schultze-Mosgau S

Abstract
BACKGROUND: The influence of orbital fractures and their repair on the rate of deformities of the lower eyelid is an ongoing source of discussion in the literature. Most of the present studies include isolated blow-out as well as combined orbital fractures.
MATERIAL AND METHODS: We present a retrospective evaluation of a series of 100 patients after isolated blow-out fracture repair using reference anthropometric data on standardized photographs. Analysis included eye fissure width and height, lid sulcus height, upper lid height, upper and lower iris coverage, position of cornea to palpebra inferior, canthal tilt, scleral show, ectropion and entropion. It was clearly distinguished between operated and contralateral eyelid, whether a transconjunctival or a subciliary approach was performed and amount of fracture. Our main interests were changes of the aforementioned parameters with regards to eyelid deformities.
RESULTS: Surgery per se did not significantly influence eyelid deformities. However, the surgical approach selected significantly affected eye fissure index, lower iris coverage and rate of scleral show, indicating retraction of the lower eyelid.
CONCLUSIONS: The standardized measurements described here are accurate and objective to evaluate postoperative results. The subciliary approach included the highest risk of lower lid retraction as compared to transconjunctival approaches.

PMID: 26595833 [PubMed - as supplied by publisher]

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