MicroRNAs are involved in cervical cancer development, progression, clinical outcome and improvement treatment response (Review)
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Víctor González-Quintana, Lizbeth Palma-Berré, Alma D. Campos-Parra, Eduardo López‑Urrutia, Oscar Peralta-Zaragoza, Rafael Vazquez-Romo, Carlos Pérez-Plasencia |
Curcumin improves the efficacy of cisplatin by targeting cancer stem-like cells through p21 and cyclin D1-mediated tumour cell inhibition in non-small cell lung cancer cell lines
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Puteri Baharuddin, Nazilah Satar, Kamal Shaik Fakiruddin, Norashikin Zakaria, Moon Nian Lim, Narazah Mohd Yusoff, Zubaidah Zakaria, Badrul Hisham Yahaya |
Depletion of Cks1 and Cks2 expression compromises cell proliferation and enhance chemotherapy-induced apoptosis in HepG2 cells
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Lingqing Lin, Zanxi Fang, Huayue Lin, Hanyu You, Jiajia Wang, Yuanhui Su, Fen Wang, Zhong‑Ying Zhang |
Expansion of quiescent lung adenocarcinoma CD8+ T cells by MUC1-8-mer peptide-T2 cell-β2 microglobulin complexes
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J. A. Atzin-Méndez, J. S. López-González, R. Báez, M. C. Arenas-Del Angel, L. F. Montaño, D. Silva-Adaya, R. Lascurain, P. Gorocica |
Chloroquine inhibits hepatocellular carcinoma cell growth in vitro and in vivo
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Tao Hu, Pei Li, Zhongguang Luo, Xiaoyu Chen, Jingyang Zhang, Chunyao Wang, Ping Chen, Ziming Dong |
Latexin exhibits tumor-suppressor potential in pancreatic ductal adenocarcinoma
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Zhanxiong Xue, Yuhui Zhou, Cheng Wang, Jihang Zheng, Pu Zhang, Lingling Zhou, Liang Wu, Yunfeng Shan, Mengsi Ye, Yun He, Zhenzhai Cai |
Suppressive effects of 3-bromopyruvate on the proliferation and the motility of hepatocellular carcinoma cells
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Minoru Tomizawa, Fuminobu Shinozaki, Yasufumi Motoyoshi, Takao Sugiyama, Shigenori Yamamoto, Naoki Ishige |
Methylation-induced silencing of miR-34a enhances chemoresistance by directly upregulating ATG4B-induced autophagy through AMPK/mTOR pathway in prostate cancer
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Haiqiu Liao, Yang Xiao, Yingbin Hu, Yangming Xiao, Zhaofa Yin, Liang Liu, Xiaopeng Kang, Yonggang Chen |
MicroRNA-21 induces breast cancer cell invasion and migration by suppressing smad7 via EGF and TGF-β pathways
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Mingli Han, Fang Wang, Yuanting Gu, Xinhong Pei, Guangcheng Guo, Chao Yu, Lin Li, Mingzhi Zhu, Youyi Xiong, Yimeng Wang |
TMPRSS3 modulates ovarian cancer cell proliferation, invasion and metastasis
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Dan Zhang, Shuang Qiu, Qi Wang, Jianhua Zheng |
Effects of lentivirus-mediated shRNA targeting integrin-linked kinase on oral squamous cell carcinoma in vitro and in vivo
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Lin Que, Dan Zhao, Xiu-Fa Tang, Ji-Yuan Liu, Xiang-Yu Zhang, Yu-Hua Zhan, Lei Zhang |
Effects of HPV-16 infection on hypopharyngeal squamous cell carcinoma and FaDu cells
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Wuhao Lu, Long Feng, Ping Li, Yuanyuan Wang, Yuwen Du, Xiaonan Chen, Shujun Wu, Guoqiang Zhao, Weihua Lou |
Lauric acid can improve the sensitization of Cetuximab in KRAS/BRAF mutated colorectal cancer cells by retrievable microRNA-378 expression
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Wen-Hui Weng, Wai-Hung Leung, Yeu-Jye Pang, Hsi-Hsien Hsu |
The natural compound codonolactone attenuates TGF-β1-mediated epithelial-to-mesenchymal transition and motility of breast cancer cells
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Jianjiang Fu, Xiaoqin Ke, Songlin Tan, Ting Liu, Shan Wang, Junchao Ma, Hong Lu |
The MRTF-A/B function as oncogenes in pancreatic cancer
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Zhao Song, Zhao Liu, Jing Sun, Feng-Lei Sun, Chuan-Zhi Li, Jiu-Zheng Sun, Li-You Xu |
Promoter hypermethylation of PTPL1, PTPN6, DAPK, p16 and 5-azacitidine inhibits growth in DLBCL
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Wenming Wang, Jing Wang, Zhengqian Li, Mingxia Zhu, Zhe Zhang, Yanfang Wang, Hongmei Jing |
Multidrug resistance-associated protein 4 is a determinant of arsenite resistance
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Bo Yuan, Yuta Yoshino, Hisayo Fukushima, Svetlana Markova, Norio Takagi, Hiroo Toyoda, Deanna L. Kroetz |
Significance of DEK overexpression for the prognostic evaluation of non-small cell lung carcinoma
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Xin Liu, Dongdong Qi, Jujie Qi, Zeshu Mao, Xiangdan Li, Jinhui Zhang, Jinzi Li, Wenbin Gao |
Recombinant HE4 protein promotes proliferation of pancreatic and endometrial cancer cell lines
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Qinsheng Lu, Haibin Chen, Christopher Senkowski, Jianhao Wang, Xue Wang, Steven Brower, Wayne Glasgow, David Byck, Shi-Wen Jiang, Jinping Li |
Construction of human single-chain variable fragment antibodies of medullary thyroid carcinoma and single photon emission computed tomography/computed tomography imaging in tumor-bearing nude mice
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Qiong Liu, Hua Pang, Xiaoli Hu, Wenbo Li, Jimei Xi, Lu Xu, Jing Zhou |
Platelet-activating factor promotes motility in breast cancer cells and disrupts non-transformed breast acinar structures
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V. Libi Anandi, K. A. Ashiq, K. Nitheesh, M. Lahiri |
The pancreatic cancer secreted REG4 promotes macrophage polarization to M2 through EGFR/AKT/CREB pathway
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Xiuying Ma, Deqing Wu, Shu Zhou, Feng Wan, Hua Liu, Xiaorong Xu, Xuanfu Xu, Yan Zhao, Maochun Tang |
Imatinib mesylate induces mitochondria-dependent apoptosis and inhibits invasion of human pigmented villonodular synovitis fibroblast-like synovial cells
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Kang Chen, Qiao Ren, Xiao-Rui Han, Xiao-Nan Zhang, Bo Wei, Xi-Zhuang Bai |
Nicotine enhances invasion and metastasis of human colorectal cancer cells through the nicotinic acetylcholine receptor downstream p38 MAPK signaling pathway
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Tao Xiang, Rushan Fei, Zhe Wang, Zhonglei Shen, Jing Qian, Wenbin Chen |
Identification of the metastasis potential and its associated genes in melanoma multinucleated giant cells using the PHA-ECM830 fusion method
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Ruifang Mi, Chunxiao Pan, Yiqiang Zhou, Yuanbo Liu, Guishan Jin, Fusheng Liu |
The differentiation of hMSCs counteracts their migration capability and pro‑angiogenic effects in vitro
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A. Scherzed, S. Hackenberg, K. Froelich, K. Rak, P. Schendzielorz, T. Gehrke, R. Hagen, N. Kleinsasser |
β-elemonic acid inhibits the cell proliferation of human lung adenocarcinoma A549 cells: The role of MAPK, ROS activation and glutathione depletion
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Tsu‑Tuan Wu, Chien‑Lin Lu, Hen‑I Lin, Bing‑Fang Chen, Guey‑Mei Jow |
Sirtuin inhibitors, EX527 and AGK2, suppress cell migration by inhibiting HSF1 protein stability
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Hyun-Woo Kim, Soo -A Kim, Sang-Gun Ahn |
Adenovirus-mediated p53 and ING4 gene co‑transfer elicitssynergistic antitumor effects through enhancement ofp53 acetylation in breast cancer
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Jie Wu, Yanbo Zhu, Chun Xu, Hong Xu, Xiumin Zhou, Jicheng Yang, Yufeng Xie, Min Tao |
Impact of KITENIN on tumor angiogenesis and lymphangiogenesis in colorectal cancer
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Hyung-Hoon Oh, Kang-Jin Park, Nuri Kim, Sun-Young Park, Young‑Lan Park, Chan-Young Oak, Dae-Seong Myung, Sung-Bum Cho, Wan‑Sik Lee, Kyung-Keun Kim, Young-Eun Joo |
Snail-induced EMT promotes cancer stem cell-like properties in head and neck cancer cells
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Ichiro Ota, Takashi Masui, Miyako Kurihara, Jong-In Yook, Shinji Mikami, Takahiro Kimura, Keiji Shimada, Noboru Konishi, Katsunari Yane, Toshiaki Yamanaka, Tadashi Kitahara |
Type III TGF-β receptor inhibits cell proliferation and migration in salivary glands adenoid cystic carcinoma by suppressing NF-κB signaling
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Dongyang Xu, Duo Li, Zhiyong Lu, Xingli Dong, Xiaofeng Wang |
miR-146b-5p promotes invasion and metastasis contributing to chemoresistance in osteosarcoma by targeting zinc and ring finger 3
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Enjie Xu, Jianquan Zhao, Jun Ma, Ce Wang, Chenglin Zhang, Heng Jiang, Jianyang Cheng, Rui Gao, Xuhui Zhou |
miR-124 suppresses the migration and invasion of glioma cells in vitro via Capn4
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Jia-Jun Cai, Zeng-Xin Qi, Ling-Chao Chen, Yu Yao, Yan Gong, Ying Mao |
Gallic acid, a phenolic compound, exerts anti-angiogenic effects via the PTEN/AKT/HIF-1α/VEGF signaling pathway in ovarian cancer cells
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Zhiping He, Allen Y. Chen, Yon Rojanasakul, Gary O. Rankin, Yi Charlie Chen |
Correlation between the promoter methylation status of ATP-binding cassette sub-family G member 2 and drug sensitivity in colorectal cancer cell lines
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Hyun‑Hye Moon, Sung‑Hee Kim, Ja‑Lok Ku |
Resolvin D1 and E1 alleviate the progress of hepatitis toward liver cancer in long-term concanavalin A-induced mice through inhibition of NF-κB activity
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Haoyu Kuang, Xiaoli Hua, Jianhui Zhou, Rui Yang |
Upregulation of long non-coding RNA PRNCR1 in colorectal cancer promotes cell proliferation and cell cycle progression
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Liu Yang, Mantang Qiu, Youtao Xu, Jie Wang, Yanyan Zheng, Ming Li, Lin Xu, Rong Yin |
Comparison of human gut microbiota in control subjects and patients with colorectal carcinoma in adenoma: Terminal restriction fragment length polymorphism and next-generation sequencing analyses
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Chika Kasai, Kazushi Sugimoto, Isao Moritani, Junichiro Tanaka, Yumi Oya, Hidekazu Inoue, Masahiko Tameda, Katsuya Shiraki, Masaaki Ito, Yoshiyuki Takei, Kojiro Takase |
Icaritin acts synergistically with epirubicin to suppress bladder cancer growth through inhibition of autophagy
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Xiu-Wu Pan, Lin Li, Yi Huang, Hai Huang, Dan-Feng Xu, Yi Gao, Lu Chen, Ji-Zhong Ren, Jian-Wei Cao, Yi Hong, Xin-Gang Cui |
Resveratrol sensitizes glioblastoma-initiating cells to temozolomide by inducing cell apoptosis and promoting differentiation
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Hao Li, Yaodong Liu, Yumin Jiao, Anchen Guo, Xiaoxue Xu, Xianjun Qu, Shuo Wang, Jizong Zhao, Ye Li, Yong Cao |
Jumonji domain containing 2A predicts prognosis and regulates cell growth in lung cancer depending on miR-150
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Weihua Xu, Kanqiu Jiang, Mingjing Shen, Yongbing Chen, Hao-Yue Huang |
TCEB2 confers resistance to VEGF‑targeted therapy in ovarian cancer
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Zhuo Deng, Jiancheng Zhou, Xi Han, Xu Li |
MicroRNA-616 promotes the migration, invasion and epithelial-mesenchymal transition of HCC by targeting PTEN
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Di Zhang, Peihua Zhou, Wei Wang, Xiaolong Wang, Junhui Li, Xuejun Sun, Li Zhang |
Matrine inhibits the proliferation, invasion and migration of castration-resistant prostate cancer cells through regulation of the NF-κB signaling pathway
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Qi Li, Yiming Lai, Chengbin Wang, Guibin Xu, Zheng He, Xiaohong Shang, Yi Sun, Fan Zhang, Leyuan Liu, Hai Huang |
Selecting molecular therapeutic drug targets based on the expression profiles of intrahepatic cholangiocarcinomas and miRNA-mRNA regulatory networks
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Boshi Sun, Changming Xie, Tongsen Zheng, Dalong Yin, Jiabei Wang, Yingjian Liang, Yuejin Li, Guangchao Yang, Huawen Shi, Tiemin Pei, Jihua Han, Lianxin Liu |
Clinical significance of Gremlin 1 in cervical cancer and its effects on cancer stem cell maintenance
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Masakazu Sato, Kei Kawana, Asaha Fujimoto, Mitsuyo Yoshida, Hiroe Nakamura, Haruka Nishida, Tomoko Inoue, Ayumi Taguchi, Juri Takahashi, Katsuyuki Adachi, Kazunori Nagasaka, Yoko Matsumoto, Osamu Wada‑Hiraike, Katsutoshi Oda, Yutaka Osuga, Tomoyuki Fujii |
miRNA expression profile of vulvar squamous cell carcinoma and identification of the oncogenic role of miR-590-5p
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Xiuhua Yang, Xin Wu |
Paxillin is positively correlated with the clinicopathological factors of colorectal cancer, and knockdown of Paxillin improves sensitivity to cetuximab in colorectal cancer cells
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Chuang Du, Xin Wang, Junling Zhang, Xiangzheng Liu, Jing Zhu, Yucun Liu |
Cell motility and spreading promoted by CEACAM6 through cyclin D1/CDK4 in human pancreatic carcinoma
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Lu Yan, Yuan Wang, Zhi-Zhi Wang, Yan-Ting Rong, Lin-Lin Chen, Qian Li, Ting Liu, Yong-Heng Chen, Yan-Dong Li, Zhao-Hong Huang, Jie Peng |
Schwann cells promote EMT and the Schwann-like differentiation of salivary adenoid cystic carcinoma cells via the BDNF/TrkB axis
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Chun Shan, Jianhua Wei, Rui Hou, Baolei Wu, Zihui Yang, Lei Wang, Delin Lei, Xinjie Yang |
The clinical significance of transforming acidic coiled-coil protein 3 expression in non-small cell lung cancer
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Feng Jiang, Bohua Kuang, Yi Que, Zhirui Lin, Li Yuan, Wei Xiao, Ruiqing Peng, Xiaoshi Zhang, Xing Zhang |
Fra-1 is upregulated in lung cancer tissues and inhibits the apoptosis of lung cancer cells by the P53 signaling pathway
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Guangwei Zhong, Xi Chen, Xia Fang, Dongsheng Wang, Mingxuan Xie, Qiong Chen |
Biomarker triplet NAMPT/VEGF/HER2 as a de novo detection panel for the diagnosis and prognosis of human breast cancer
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Yanyan Zhu, Meiyan Guo, Lingyun Zhang, Tao Xu, Li Wang, Guoxiong Xu |
Esophageal squamous cell carcinoma cell proliferation induced by exposure to low concentration of cigarette smoke extract is mediated via targeting miR-101-3p/COX-2 pathway
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Jian Gong, Yi Chu, Meili Xu, Jirong Huo, Liang Lv |
Resveratrol induces cell cycle arrest in human gastric cancer MGC803 cells via the PTEN‑regulated PI3K/Akt signaling pathway
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Xiaoping Jing, Weiwei Cheng, Shiying Wang, Pin Li, Li He |
Knockdown of long non-coding RNA HOTAIR inhibits proliferation and invasiveness and improves radiosensitivity in colorectal cancer
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Xiao-Dong Yang, Hong-Tao Xu, Xiao-Hui Xu, Gan Ru, Wei Liu, Jun-Jia Zhu, Yong-You Wu, Kui Zhao, Yong Wu, Chun-Gen Xing, Shu-Yu Zhang, Jian-Ping Cao, Ming Li |
PBOV1 correlates with progression of ovarian cancer and inhibits proliferation of ovarian cancer cells
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Lan Wang, Chun-Hao Niu, Shu Wu, Hong-Mei Wu, Fei Ouyang, Mian He, Shan-Yang He |
miR-296-5p suppresses cell viability by directly targeting PLK1 in non-small cell lung cancer
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Chun Xu, Sen Li, Tengfei Chen, Haibo Hu, Cheng Ding, Zhenlei Xu, Jun Chen, Zeyi Liu, Zhe Lei, Hong-Tao Zhang, Chang Li, Jun Zhao |
n-3 polyunsaturated fatty acids reverse the development of polyps in ApcMin/+ transgenic mice
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Maria Notarnicola, Valeria Tutino, Maria Gabriella Caruso, Antonio Francavilla |
Pien Tze Huang inhibits the proliferation, and induces the apoptosis and differentiation of colorectal cancer stem cells via suppression of the Notch1 pathway
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Fei Qi, Lihui Wei, Aling Shen, Youqin Chen, Jiumao Lin, Jianfeng Chu, Qiaoyan Cai, Jie Pan, Jun Peng |
A positive feedback loop of p53/miR-19/TP53INP1 modulates pancreatic cancer cell proliferation and apoptosis
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Xiaofang Wang, Lei Wang, Qingjiang Mo, Ankui Jia, Yuqian Dong, Guoqiang Wang |
Resveratrol induces human keratinocyte damage via the activation of class III histone deacetylase, Sirt1
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Ju-Hee Lee, Jin-Shang Kim, Sang-Youel Park, You-Jin Lee |
Ezrin-radixin-moesin-binding phosphoprotein-50 regulates EGF-induced AKT activation through interaction with EGFR and PTEN
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Junfang Zheng, Yuanping Dai, Zhiyu Yang, Longyan Yang, Zhiqiang Peng, Ran Meng, Ying Xiong, Junqi He |
Human chorionic gonadotropin β subunit affects the expression of apoptosis-regulating factors in ovarian cancer
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Anna Szczerba, Aleksandra Śliwa, Marta Kubiczak, Ewa Nowak-Markwitz, Anna Jankowska |
Auranofin induces mesothelioma cell death through oxidative stress and GSH depletion
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Bo Ra You, Woo Hyun Park |
Klotho inhibits human follicular thyroid cancer cell growth and promotes apoptosis through regulation of the expression of stanniocalcin-1
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Dong Dai, Qi Wang, Xiaofeng Li, Jianjing Liu, Xiaoying Ma, Wengui Xu |
MicroRNA-22 functions as a tumor suppressor by targeting SIRT1 in renal cell carcinoma
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Shoulin Zhang, Dongmei Zhang, Chunguang Yi, Yinping Wang, Hongan Wang, Jian Wang |
Bergapten induces metabolic reprogramming in breast cancer cells
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Marta Santoro, Carmela Guido, Francesca De Amicis, Diego Sisci, Erika Cione, Dolce Vincenza, Ada Donà, Maria Luisa Panno, Saveria Aquila |
Effects of 2-methoxyestradiol on apoptosis and HIF-1α and HIF‑2α expression in lung cancer cells under normoxia and hypoxia
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Arnoldo Aquino-Gálvez, Georgina González-Ávila, Javier Delgado-Tello, Manuel Castillejos-López, Criselda Mendoza-Milla, Joaquín Zúñiga, Marco Checa, Héctor Aquiles Maldonado-Martínez, Axel Trinidad-López, José Cisneros, Luz María Torres-Espíndola, Claudia Hernández-Jiménez, Bettina Sommer, Carlos Cabello-Gutiérrez, Luis H. Gutiérrez-González |
Overexpression of lysine-specific demethylase 1 promotes androgen-independent transition of human prostate cancer LNCaP cells through activation of the AR signaling pathway and suppression of the p53 signaling pathway
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Xuechao Li, Tao Li, Dehong Chen, Peng Zhang, Yarong Song, Hongxue Zhu, Yajun Xiao, Yifei Xing |
Time-staggered inhibition of JNK effectively sensitizes chemoresistant ovarian cancer cells to cisplatin and paclitaxel
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Manabu Seino, Masashi Okada, Hirotsugu Sakaki, Hiroyuki Takeda, Hikaru Watarai, Shuhei Suzuki, Shizuka Seino, Kenta Kuramoto, Tsuyoshi Ohta, Satoru Nagase, Hirohisa Kurachi, Chifumi Kitanaka |
[Corrigendum] Trastuzumab and docetaxel in a preclinical organotypic breast cancer model using tissue slices from mammary fat pad: Translational relevance
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Loredana Vesci, Valeria Carollo, Giuseppe Roscilli, Luigi Aurisicchio, Fabiana Fosca Ferrara, Luigi Spagnoli, Rita De Santis |
Τρίτη 12 Ιανουαρίου 2016
Oncology Reports
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma.
Human epidermal growth factor receptor 2/neu as a novel therapeutic target in sinonasal undifferentiated carcinoma.
Head Neck. 2016 Jan 11;
Authors: Takahashi Y, Lee J, Pickering C, Bell D, Jiffar TW, Myers JN, Hanna EY, Kupferman ME
Abstract
BACKGROUND: Sinonasal undifferentiated carcinoma (SNUC) is a rare and aggressive cancer. Despite multimodal therapy, the prognosis in SNUC remains poor, and new therapies are needed. Thus, the purpose of this study was to explore potential therapeutic targets in SNUC.
METHODS: Using the human-derived SNUC MDA8788-6 cell line, we performed whole genome single nucleotide polymorphism (SNP) analysis to identify copy number changes in this line. Protein expression levels were evaluated by Western blotting. Cell growth inhibition was assessed by methylthiazol tetrazolium (MTT) and clonogenic assays. The mouse flank model was used to examine the effect of growth inhibition in vivo.
RESULTS: The ERBB2 gene was highly amplified and cell extracts showed human epidermal growth factor receptor 2 (HER2) was overexpressed and phosphorylated in MDA8788-6. Lapatinib effectively inhibited the HER2 signaling pathway in our SNUC cell line. HER2 inhibition successfully suppressed the cell growth of MDA8788-6 cells both in vitro and in vivo.
CONCLUSION: Targeting HER2 may be a promising avenue for the development of novel therapies for SNUC. © 2016 Wiley Periodicals, Inc. Head Neck, 2016.
PMID: 26752332 [PubMed - as supplied by publisher]
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Audiological comparison between two different clips prostheses in stapes surgery.
Audiological comparison between two different clips prostheses in stapes surgery.
Rev Laryngol Otol Rhinol (Bord). 2015;136(1):33-6
Authors: Potena M, Portmann D, Guindi S
Abstract
OBJECTIVES: To compare audiometric results and complications of stapes surgery with two different types of piston prosthesis, the Portmann Clip Piston (Medtronic) (PCP) and the Soft Clip Piston (Kurz) (SCP).
MATERIAL AND METHODS: Study conducted on 64 patients who underwent primary stapedotomy from 2008 to 2011. We matched for each case of stapedotomy with the PCP (Medtronic Xomed Inc. Portmann Clip Piston Stainless Steel/Fluoroplastic) a case with the SCP (Heinz Kurz GmbH Medizintechnik Soft Piston Clip Titanium). Each group consisted of 32 patients, and patients in both groups were matched with respect to gender, age, bilateral or unilateral otosclerosis, otological symptoms (tinnitus, vertigo or dizziness), family history, operated side and the Portmann grading for otosclerosis. The length of the prosthesis used was reported. Post-operative complications such as tinnitus, vertigo, hearing loss and altered taste were documented. Each patient was subjected to a preoperative and postoperative audiogram (follow-up at the second month after the surgery). We used the Student test for statistical analysis. Statistical significance was set at < 0.01.
RESULTS: None of the patients experienced a post-operative hearing loss and none required a later revision surgery. No statistically significant difference was found between the two populations regarding demographic data (age, sex, side, bilaterality, family history, stage and lenght of piston) and hearing level (> 0.01) in the air, bone conduction and air-bone gap (ABG). Postoperative complications did not result to be significantly different between the two groups. Also, both groups showed a significant improvement (< 0.01) in the post-operative air, bone conduction and air-bone gap. There was no statistically significant difference (> 0.01) between the post-operative hearing results (bone conduction, air conduction, air-bone gap) using the two pistons. The mean ABG improvement was respectively 16.63 dB in the SCP group and 20.59 dB in the PCP group.
CONCLUSION: The titanium Soft clip piston (SCP) is a good alternative to the Portmann clip piston (PCP). Nevertheless there are some differences in the surgical fixing of these two pistons in the correct position.
PMID: 26749603 [PubMed - in process]
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Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps.
Vitamin D deficiency is associated with increased human sinonasal fibroblast proliferation in chronic rhinosinusitis with nasal polyps.
Int Forum Allergy Rhinol. 2016 Jan 11;
Authors: Carroll WW, Schlosser RJ, O'Connell BP, Soler ZM, Mulligan JK
Abstract
BACKGROUND: Vitamin D3 (VD3) is a steroid hormone with known antiproliferative properties. Patients with chronic rhinosinusitis with nasal polyps (CRSwNP) have been shown to be VD3-deficient. Moreover, VD3 deficiency is associated with worse disease in patients with CRSwNP. One cell type thought to play a role in chronic rhinosinusitis (CRS) is the human sinonasal fibroblast (HSNF). The aim of this study was to investigate VD3 deficiency and HSNF proliferation in CRSwNP.
METHODS: Blood and sinus tissue explants were collected at the time of surgery from patients with CRSwNP (n = 15). Control subjects (n = 12) were undergoing surgery for cerebrospinal fluid leak repair or to remove non-hormone-secreting pituitary tumors. Ex vivo HSNF proliferation was analyzed with flow cytometry using expression of fibroblast-specific protein (FSP) and the proliferation marker Ki67. Plasma levels of 25-hydroxyvitamin D3 (25VD3) were measured by enzyme-linked immunosorbent assay. In vitro analysis of HSNF proliferation after treatment with calcitriol (1,25VD3) was performed using carboxyfluorescein succinimidyl ester (CFSE) and analyzed with flow cytometry.
RESULTS: In CRSwNP patients there was an inverse correlation between 25VD3 and proliferating HSNFs (p = 0.0135). This correlation was not seen for control patients (p = 0.3869). In vitro analysis showed that HSNFs from patients with CRSwNP had a higher proliferation index at baseline than HSNFs from control patients (p < 0.01). When treated with 1,25VD3, there was a significant decrease in HSNF proliferation index in patients with CRSwNP (p < 0.01), but not control patients.
CONCLUSION: VD3 deficiency is associated with increased HSNF proliferation in CRSwNP. Further investigation into how HSNFs and VD3 impact CRSwNP pathophysiology is warranted.
PMID: 26750566 [PubMed - as supplied by publisher]
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Quantifying lingual coarticulation using ultrasound imaging data collected with and without head stabilisation.
 | Related Articles |
Quantifying lingual coarticulation using ultrasound imaging data collected with and without head stabilisation.
Clin Linguist Phon. 2015 Apr;29(4):249-65
Authors: Zharkova N, Gibbon FE, Hardcastle WJ
Abstract
Previous studies reporting the use of ultrasound tongue imaging with clinical populations have generally provided qualitative information on tongue movement. Meaningful quantitative measures for use in the clinic typically require the speaker's head to be stabilised in relation to a transducer, which may be uncomfortable, and unsuitable for young children. The objective of this study was to explore the applicability of quantitative measurements of stabilisation-free tongue movement data, by comparing ultrasound data collected from 10 adolescents, with and without head stabilisation. Several measures of tongue shape were used to quantify coarticulatory influence from two contrasting vowels on four different consonants. Only one of the measures was completely unaffected by the stabilisation condition for all the consonants. The study also reported cross-consonant differences in vowel-related coarticulatory effects. The implications of the findings for the theory of coarticulation and for potential applications of stabilisation-free tongue curve measurements in clinical studies are discussed.
PMID: 25651199 [PubMed - indexed for MEDLINE]
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Norwegian words: A lexical database for clinicians and researchers.
| Related Articles |
Norwegian words: A lexical database for clinicians and researchers.
Clin Linguist Phon. 2015 Apr;29(4):276-90
Authors: Lind M, Simonsen HG, Hansen P, Holm E, Mevik BH
Abstract
All words have properties linked to form, meaning and usage patterns which influence how easily they are accessed from the mental lexicon in language production, perception and comprehension. Examples of such properties are imageability, phonological and morphological complexity, word class, argument structure, frequency of use and age of acquisition. Due to linguistic and cultural variation the properties and the values associated with them differ across languages. Hence, for research as well as clinical purposes, language specific information on lexical properties is needed. To meet this need, an electronically searchable lexical database with more than 1600 Norwegian words coded for more than 12 different properties has been established. This article presents the content and structure of the database as well as the search options available in the interface. Finally, it briefly describes some of the ways in which the database can be used in research, clinical practice and teaching.
PMID: 25588015 [PubMed - indexed for MEDLINE]
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Use of pulsed dye laser treatments in patients with vocal fold mucosal bridges with sulcus vocalis-our experience of five cases.
Use of pulsed dye laser treatments in patients with vocal fold mucosal bridges with sulcus vocalis-our experience of five cases.
Clin Otolaryngol. 2016 Jan 11;
Authors: Chang JW, Park AY, Byeon HK, Choi HS
Abstract
Larger and thicker mucosal bridges are usually associated with severe dysphonia, surgical excision is the currently preferred treatment. Surgical excision of mucosal bridges may decrease vocal fold bulk and result in subsequent postoperative glottal incompetence. PDL can make a cleavage plane between the epithelium and the superficial lamina propria by denaturing the anchoring fibers of lamina lucida of the basement membrane, and this plane allows en-bloc and easy peeling of the medial epithelium of the mucosal bridge. In addition, epithelium overlying the sulcus can be vapourized or denatured by direct contact with the PDL fibres. Therefore, approximation between the de-epithelized mucosal bridge and the PDL-treated sulcus bed can be accomplished easily with preservation of the lamina propria of vocal folds. PDL may induce additional restoration of lamina propria by physiologic tissue remodeling on the accompanying sulcus vocalis with mucosal bridge PDL glottoplasty with the PDL-assisted mucosal bridge undermining technique can be an effective and safe technique, and be advised for obviating the loss of bulk due to surgical resection of the mucosal bridge. This article is protected by copyright. All rights reserved.
PMID: 26751135 [PubMed - as supplied by publisher]
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[A rare and unusual cause of dysphonia: The leech].
| Related Articles |
[A rare and unusual cause of dysphonia: The leech].
Rev Laryngol Otol Rhinol (Bord). 2014;135(2):105-6
Authors: Abou-Elfadl M, Abada RL, Rouadi S, Mahtar M, Roubal M, Essaadi M, Janah A, Kadiri F
Abstract
We report a case of dysphonia associated with intermittent episodes of hemoptysis low abundance in a patient aged 32, clinical examination is normal, nasofibroscopie objective a leech at the laryngeal orifice, extracted by direct laryngoscopy in emergency.
PMID: 26521350 [PubMed - indexed for MEDLINE]
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[Transgender voice and communication treatment: Review of the literature].
| Related Articles |
[Transgender voice and communication treatment: Review of the literature].
Rev Laryngol Otol Rhinol (Bord). 2014;135(2):97-103
Authors: Lechien JR, Delvaux V, Huet K, Khalife M, Piccaluga M, Harmegnies B, Saussez S
Abstract
Transgender persons constitute a small but growing population in ENT department: as a matter of fact, many voice parameters significantly contribute to the perception of gender (fundamental frequency, supraglottic resonance patterns, etc.). The persons involved in transition processes may therefore aim at changing their own voice properties, either by means of speech therapy or by medical intervention (hormonotherapy and/or surgery). The current voice assessment and outcome measures for this population before and after treatment are nevertheless still lacking validity. A well-accepted general framework including self-perception, subjective assessment of the practitioner and objective measures is not well documented. This review is therefore meant as a contribution to the development of a state of the art in the field.
PMID: 26521349 [PubMed - indexed for MEDLINE]
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Iatrogenic scarring of the vocal folds after phonosurgery for benign lesions. A descriptive study of 108 patients.
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Iatrogenic scarring of the vocal folds after phonosurgery for benign lesions. A descriptive study of 108 patients.
Rev Laryngol Otol Rhinol (Bord). 2014;135(2):57-61
Authors: Perouse AR, Coulombeau B
Abstract
OBJECTIVES: Patients with iatrogenic scarring of the vocal folds can present with a spectrum of dysphonia ranging from slight hoarseness to very severe dysphonia. In this paper we will describe the clinical and stroboscopic presentation of VFIS, and discuss the possibility of identifying the factors favouring such lesions.
STUDY DESIGN: A retrospective chart review from 2002 to 2011.
METHODS: A retrospective chart analysis of patients complaining of no improvement in (or worsening of) the quality of their voices after primary phono-surgery for benign lesions of the vocal folds.
RESULTS: Our series consisted of 108 patients (107 women and 1 man) with a mean age of 38.1. The initial complaint was always of no improvement in (or worsening of) voice quality more than three months after phonosurgery for benign vocal fold lesions. The overall grade of dysphonia according to Hirano's scale was 1.79 (n = 84). Voice evaluation showed forced phonation in 29% of the patients, sharp breaks or irregular vibration in 31%. The appearance of the larynx in normal and stroboscopic light is presented. The results of this study do not allow the factors favouring the occurrence of iatrogenic scars to be formally identified since in 75% of cases, the diagnosis of the initial lesion or the operative procedure used was unknown. However, the link between the initial lesion, the operating technique and the occurrence of scarring is discussed for the remaining 25%.
PMID: 26521343 [PubMed - indexed for MEDLINE]
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Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.
Decision-making and outcomes of hearing help-seekers: A self-determination theory perspective.
Int J Audiol. 2016 Jan 11;:1-10
Authors: Ridgway J, Hickson L, Lind C
Abstract
OBJECTIVE: To explore the explanatory power of a self-determination theory (SDT) model of health behaviour change for hearing aid adoption decisions and fitting outcomes.
DESIGN: A quantitative approach was taken for this longitudinal cohort study. Participants completed questionnaires adapted from SDT that measured autonomous motivation, autonomy support, and perceived competence for hearing aids. Hearing aid fitting outcomes were obtained with the international outcomes inventory for hearing aids (IOI-HA). Sociodemographic and audiometric information was collected.
STUDY SAMPLE: Participants were 216 adult first-time hearing help-seekers (125 hearing aid adopters, 91 non-adopters).
RESULTS: Regression models assessed the impact of autonomous motivation and autonomy support on hearing aid adoption and hearing aid fitting outcomes. Sociodemographic and audiometric factors were also taken into account. Autonomous motivation, but not autonomy support, was associated with increased hearing aid adoption. Autonomy support was associated with increased perceived competence for hearing aids, reduced activity limitation and increased hearing aid satisfaction. Autonomous motivation was positively associated with hearing aid satisfaction.
CONCLUSION: The SDT model is potentially useful in understanding how hearing aid adoption decisions are made, and how hearing health behaviour is internalized and maintained over time. Autonomy supportive practitioners may improve outcomes by helping hearing aid adopters maintain internalized change.
PMID: 26750770 [PubMed - as supplied by publisher]
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Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.
Initial classification of pediatric hearing impairment using behavioral measures of early prelingual auditory development.
Int J Audiol. 2016 Jan 11;:1-8
Authors: Liang S, Soli SD, Zheng Y, Li G, Meng Z
Abstract
OBJECTIVE: Determine the sensitivity, specificity, and accuracy of pediatric hearing loss classification using behavioral evidence of early prelingual auditory development (EPLAD). Validate behavioral measures of EPLAD.
DESIGN: EPLAD was assessed in a prospective sample of hearing-impaired children using the infant-toddler meaningful auditory integration scale (ITMAIS/MAIS). Hearing losses were classified using tone-burst auditory brainstem response (ABR) and ITMAIS/MAIS scores. This process was repeated in a second retrospective sample.
STUDY SAMPLE: The prospective sample was comprised of 139 hearing-impaired children under five years of age. Approximately equal proportions of mild-moderate, severe, and profound losses were included. The second retrospective sample was comprised of case records for 144 hearing-impaired children meeting the same selection criteria. This sample contained more than 80% profound losses.
RESULTS: EPLAD trajectories reached different asymptotes after two years of age, depending on the severity of hearing loss, allowing children over this age to be classified. The sensitivity of EPLAD classifications was over 90%; specificity was over 82%; and accuracy was over 88%.
CONCLUSIONS: Behavioral evidence of EPLAD provides an initial means of classifying pediatric hearing losses which can facilitate initial treatment options prior to diagnostic evaluation with tone-burst ABR.
PMID: 26750766 [PubMed - as supplied by publisher]
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Simulation-based otolaryngology - head and neck surgery boot camp: 'how I do it'.
Simulation-based otolaryngology - head and neck surgery boot camp: 'how I do it'.
J Laryngol Otol. 2016 Jan 11;:1-7
Authors: Chin CJ, Chin CA, Roth K, Rotenberg BW, Fung K
Abstract
BACKGROUND: In otolaryngology, surgical emergencies can occur at any time. An annual surgical training camp (or 'boot camp') offers junior residents from across North America the opportunity to learn and practice these skills in a safe environment. The goals of this study were to describe the set-up and execution of a simulation-based otolaryngology boot camp and to determine participants' confidence in performing routine and emergency on-call procedures in stressful situations before and after the boot camp.
METHODS: There were three main components of the boot camp: task trainers, simulations and an interactive panel discussion. Surveys were given to participants before and after the boot camp, and their confidence in performing the different tasks was assessed via multiple t-tests.
RESULTS: Participants comprised 22 residents from 12 different universities; 10 of these completed both boot camp surveys. Of the nine tasks, the residents reported a significant improvement in confidence levels for six, including surgical airway and orbital haematoma management.
CONCLUSION: An otolaryngology boot camp gives residents the chance to learn and practice emergency skills before encountering the emergencies in everyday practice. Their confidence in multiple skillsets was significantly improved after the boot camp. Given the shift towards competency-based learning in medical training, this study has implications for all surgical and procedural specialties.
PMID: 26750335 [PubMed - as supplied by publisher]
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Primary Larynx Cryptococcus neoformans Infection: A Distinctive Clinical Entity.
Primary Larynx Cryptococcus neoformans Infection: A Distinctive Clinical Entity.
Open Forum Infect Dis. 2015 Dec;2(4):ofv160
Authors: Bergeron M, Gagné AA, Côté M, Chênevert J, Dubé R, Pelletier R
Abstract
Cryptococcus neoformans can directly infect the vocal cords. Endoscopic findings were undistinctive from most infiltrative diseases. Tissue biopsy was essential for the diagnosis. Inhaled corticosteroids can predispose to the infection, and fluconazole 400 mg daily for at least 6 weeks appeared to be minimal to achieve a permanent cure.
PMID: 26753169 [PubMed - as supplied by publisher]
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Bronchipret® syrup containing thyme and ivy extracts suppresses bronchoalveolar inflammation and goblet cell hyperplasia in experimental bronchoalveolitis.
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Bronchipret® syrup containing thyme and ivy extracts suppresses bronchoalveolar inflammation and goblet cell hyperplasia in experimental bronchoalveolitis.
Phytomedicine. 2015 Dec 1;22(13):1172-7
Authors: Seibel J, Pergola C, Werz O, Kryshen K, Wosikowski K, Lehner MD, Haunschild J
Abstract
BACKGROUND/PURPOSE: Acute bronchitis (AB) is a common lung condition characterized by inflammation of the large bronchi in response to infection. Bronchipret(®) syrup (BRO), a fixed combination of thyme and ivy extracts has been effectively used for the treatment of AB. Combining in vivo and mechanistic in vitro studies we aimed to provide a better understanding of the therapeutic potential of BRO on key aspects of AB and to identify potential mechanisms of action.
METHODS: Bronchoalveolitis in rats was induced by intratracheal LPS instillation. BRO was administered p.o. once daily at 1- to 10-fold equivalents of the human daily dose. Animals were sacrificed 24-72 h post LPS challenge to analyze leukocyte numbers in lung tissue, bronchoalveolar lavage fluid (BALF) and blood as well as goblet cells in bronchial epithelium. Inhibitory effects of BRO analogue on leukotriene (LT) production were determined in human neutrophils and monocytes as well as on isolated 5-lipoxygenase (5-LO).
RESULTS: BRO significantly reversed the LPS-induced increase in leukocyte numbers in lung tissue, BALF and blood as well as goblet cell numbers in bronchial epithelium. In vitro, BRO analogue suppressed cellular release of LTB4 (IC50 = 36 µg⋅ml(-1)) and cysLT (IC50 = 10 µg⋅ml(-1)) and inhibited the activity of isolated 5-LO (IC50 = 19 µg⋅ml(-1)).
CONCLUSION: BRO exerts significant anti-inflammatory effects and attenuates goblet cell metaplasia in LPS-induced bronchoalveolitis in vivo potentially via interference with 5-LO/LT signaling. These effects may contribute to its observed clinical efficacy in AB.
PMID: 26598916 [PubMed - indexed for MEDLINE]
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[A rare and unusual cause of dysphonia: The leech].
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[A rare and unusual cause of dysphonia: The leech].
Rev Laryngol Otol Rhinol (Bord). 2014;135(2):105-6
Authors: Abou-Elfadl M, Abada RL, Rouadi S, Mahtar M, Roubal M, Essaadi M, Janah A, Kadiri F
Abstract
We report a case of dysphonia associated with intermittent episodes of hemoptysis low abundance in a patient aged 32, clinical examination is normal, nasofibroscopie objective a leech at the laryngeal orifice, extracted by direct laryngoscopy in emergency.
PMID: 26521350 [PubMed - indexed for MEDLINE]
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Early evaluation of voice quality in glottic cancer (T1, T2) following curative radiotherapy.
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Early evaluation of voice quality in glottic cancer (T1, T2) following curative radiotherapy.
Rev Laryngol Otol Rhinol (Bord). 2014;135(2):91-6
Authors: Tripathi N, Verma RK, Panda NK, Ghosal S, Sharma A
Abstract
BACKGROUND: This is prospective study analyzing the subjective and objective quality of voice and voice related quality of life in patients of early glottic cancer (T1, T2 disease) before and after receiving curative radiotherapy.
METHODS: Fifteen patients of early glottic carcinoma (T1, T2) underwent voice assessment using multidimensional voice protocol based on recommendation by European Laryngological Society which included Perceptual analysis of voice by speech therapist and otolaryngologist, acoustic analysis; aerodynamic efficiency analysis-Maximum phonation time; patient's self perception of voice analysis--Voice handicap index; and videolaryngostroboscopy. Assessment was done prior to commencement of radiation therapy and at 1 month and 3 months following radio- therapy.
RESULTS: There was significant improvement in majority of the voice parameters post radiotherapy. Perceptual analysis showed significant improvement in GRBAS score following radiotherapy. Perturbation measures (jitter, shimmer, SNR, HNR) showed improvement post radiotherapy though remained inferior compared to controls. Mean fundamental frequency (Mean F0) and habitual frequency (habitual F0) decreased post radiotherapy. Intensity of voice increased following radiotherapy which was statistically significant (p < 0.05). There was significant improvement in the patient's perception of their quality of voice and voice related quality of life post radiotherapy. Maximum phonation time showed statistically significant improvement post-radiotherapy. Perceptual analysis of voice by professional observer correlated well with patients self perception of his own voice.
CONCLUSION: Voice quality improves following radiotherapy but not all the patients regain normal voice. Improvement in voice quality improves quality of life of patients shown by improved voice handicap index.
PMID: 26521348 [PubMed - indexed for MEDLINE]
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Trans-ciliary minimally invasive keyhole craniotomy for skull base and vascular lesions.
Trans-ciliary minimally invasive keyhole craniotomy for skull base and vascular lesions.
J Neurosci Rural Pract. 2015 Oct-Dec;6(4):636-638
Authors: Kumar VR, Madhugiri VS, Ramesh AS, Yadav AK
PMID: 26752926 [PubMed - as supplied by publisher]
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Frontal sinus surgery and sinus distribution of nasal irrigation.
Frontal sinus surgery and sinus distribution of nasal irrigation.
Int Forum Allergy Rhinol. 2016 Jan 11;
Authors: Barham HP, Ramakrishnan VR, Knisely A, Do TQ, Chan LS, Gunaratne DA, Weston JD, Seneviratne S, Marcells GN, Sacks R, Harvey RJ
Abstract
BACKGROUND: Effective mucus lavage and delivery of topical pharmaceuticals are central to successful management of chronic rhinosinusitis (CRS). The frontal sinus remains difficult to penetrate with topical therapies. This study evaluates the benefit of Draf III frontal dissection compared to traditional Draf IIa for distribution of topical therapies.
METHODS: Fresh human cadaver heads were dissected sequentially with Draf IIa frontal sinusotomy and then Draf III procedures. Each cavity was irrigated with pediatric (120 mL) and adult (240 mL) irrigation bottles with 1/1000 10% fluorescein-labeled free water in 2 fixed positions (vertex and Frankfort horizontal). An endoscope at a fixed position within the frontal sinus recorded frontal sinus and frontal recess penetration. The images then underwent blinded evaluation of fluid distribution scored as 0 to 4 (nasal cavity only, frontal recess, medial one-half, lateral one-half, and lavage). Ordinal distribution score was analyzed with Kendall's tau-b.
RESULTS: Eight specimens (age 76 ± 11.2 years; 50% female) were assessed. Draf III was superior to Draf IIa in ability to achieve frontal sinus distribution of irrigation (90.6% vs 50.1%, p < 0.001). Vertex head position improved distribution (90.6% vs 50.1%, p < 0.001), was synergistic with Draf III (100% with 87.5% lavage, p < 0.001), but was unable to overcome Draf IIa (81.2% with 25% lavage, p < 0.001). Irrigation volume trended toward improved distribution with larger volume irrigations.
CONCLUSION: Successful treatment of sinonasal disease may require postoperative delivery of topical therapies. Draf III frontal sinusotomy achieves superior topical access, and access to the frontal sinus with Draf IIa appears limited, despite large volumes and positioning.
PMID: 26750306 [PubMed - as supplied by publisher]
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Recurrent mandibular ameloblastoma with anterior skull base invasion: Case report.
Recurrent mandibular ameloblastoma with anterior skull base invasion: Case report.
Rev Laryngol Otol Rhinol (Bord). 2015;136(1):41-3
Authors: Santini L, Varoquaux A, Giovanni A, Dessi P, Michel J
Abstract
Recurrent ameloblastoma with skull base invasion is a rare clinical entity with poor prognosis. We report a case of a mandibular ameloblastoma recurrence involving the anterior skull base. The diagnostic and therapeutic processes are presented with emphasis on the radiologic features of ameloblastoma. Another aim of this case report is to underline the importance of close and long-term follow-up after resection. Ameloblastoma recurrences are frequent and mainly occur after incomplete surgical resection. These recurrences may be diagnosed late because of lack of symptoms in the mandibular area.
PMID: 26749605 [PubMed - in process]
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Quantitative Study of Posterior Fossa Crowdedness in Hemifacial Spasm.
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Quantitative Study of Posterior Fossa Crowdedness in Hemifacial Spasm.
World Neurosurg. 2015 Oct;84(4):920-6
Authors: Cheng J, Fang Y, Zhang H, Lei D, Wu W, You C, Mao B, Mao K
Abstract
OBJECTIVE: To quantitatively study the degree of posterior fossa crowdedness (PFC) in patients with hemifacial spasm (HFS) and to further investigate whether overcrowding in posterior fossa affects the efficacy and safety of microvascular decompression.
METHODS: We conducted a prospective case-control study of patients diagnosed with HFS and sex- and age-matched healthy control patients. All subjects underwent high-resolution, 3-dimensional magnetic resonance imaging, and posterior fossa crowdedness index (PFCI) and cerebrospinal fluid volume (CSFV) were measured. Patients with HFS underwent primary microvascular decompression and long-term follow-up. Associations of PFCI and other factors with operative outcomes and complications were analyzed.
RESULTS: The study enrolled 153 subjects: 102 patients and 51 control subjects. Compared with control subjects, patients had a more PFC (PFCI: 83.2% vs. 80.2%; P = 0.005) and smaller posterior fossa CSFV (16,248.0 mm(3) vs. 20,054.0 mm(3); P = 0.001). The mean effective space of posterior fossa cerebrospinal fluid in patients with HFS was 11.8% smaller than in control subjects (P = 0.004). Compared with men, women showed larger PFCI (83.6% vs. 82.2%; P = 0.012) and smaller PF CSFV (16,027.5 mm(3) vs. 17,299.5 mm(3); P = 0.009). Sixty-one patients (59.8%) were spasm-free immediately postoperatively, and 95 (93.1%) were spasm-free at follow-up. Complication rates were 9.8% in the short term, and 2.9% at follow-up. Lower PFCI (odds ratio [OR] 0.63; P = 0.019) and severe indention (OR 1.41; P = 0.027) were significantly associated with better short-term outcomes. Greater PFCI (OR 2.05, P = 0.008) was associated with greater early complication incidence.
CONCLUSION: Patients with HFS had more PFC. PFC potentially leads to cranial nerve and vascular structure crowding, which may increase HFS risk. PFC was significantly associated with poor short-term outcomes and greater incidence of early complications but not long-term outcomes and complications.
PMID: 26341431 [PubMed - indexed for MEDLINE]
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35-Year-Old Man with Lytic Skull Lesion. Langerhans Cell Histiocytosis (LCH).
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35-Year-Old Man with Lytic Skull Lesion. Langerhans Cell Histiocytosis (LCH).
Brain Pathol. 2015 May;25(3):367-8
Authors: Schutz PW, Honey CR, Yip S
PMID: 26086055 [PubMed - indexed for MEDLINE]
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Radiographic Evaluation and Clinical Implications of Venous Connections Between Dural Arteriovenous Fistula of the Cavernous Sinus and Cerebellum and the Pontomedullary Venous System.
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Radiographic Evaluation and Clinical Implications of Venous Connections Between Dural Arteriovenous Fistula of the Cavernous Sinus and Cerebellum and the Pontomedullary Venous System.
World Neurosurg. 2015 Oct;84(4):1112-26
Authors: Kobkitsuksakul C, Jiarakongmun P, Chanthanaphak E, Pongpech S
Abstract
OBJECTIVE: The types of cortical venous reflux channels, posterior fossa and pontomesencephalic venous reflux or their connections with the cavernous sinus (CS) are inadequately described in the literature. This study uses angiography, magnetic resonance imaging, and X-ray computed tomography to clarify the possible route of cavernous dural arteriovenous fistulae (CVDAVF) that causes posterior fossa and pontomedullary venous reflux and documents the clinical presentations associated with the reflux.
METHODS: Eighty-six patients with CSDAVF treated at Ramathibodi Hospital, Bangkok, Thailand, during 2009 to 2013 were studied retrospectively. Sixteen cases with posterior fossa and pontomedullary venous reflux were included for analysis.
RESULTS: Bridging veins serve as an important pathway for venous reflux from CS to the posterior fossa and brainstem. The uncal vein directly terminates at the CS and has several connecting routes, ranging from the inferior frontal lobes and insula to the posterior fossa through the basal vein of Rosenthal. The petrosal vein was most frequently and easily detected angiographically. It plays a major role in the cerebellar hemispheric venous reflux. Only 1 patient developed brainstem and cerebellar venous congestion, which returned to normal after endovascular treatment.
CONCLUSIONS: Connections of CS are not limited to intercavernous, ophthalmic veins, sphenoparietal sinuses, and inferior and superior petrosal sinuses. They also occur with complex venous drainages at the base of the frontotemporal lobes, insula, brainstem, and cerebellum. Knowledge of the venous connection of CS is key to understanding the possible locations of venous congestion/hemorrhage and the clinical presentation of patients with CSDAVF.
PMID: 26074430 [PubMed - indexed for MEDLINE]
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Long-Term Outcomes After Small-Bone-Window Posterior Fossa Decompression and Duraplasty in Adults with Chiari Malformation Type I.
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Long-Term Outcomes After Small-Bone-Window Posterior Fossa Decompression and Duraplasty in Adults with Chiari Malformation Type I.
World Neurosurg. 2015 Oct;84(4):998-1004
Authors: Deng X, Yang C, Gan J, Wu L, Yang T, Yang J, Xu Y
Abstract
BACKGROUND: Small-bone-window posterior fossa decompression with duraplasty is one of the popular surgical options for Chiari malformation type I, but its efficacy is controversial and the risk factors of clinical outcome remain unclear.
METHODS: The study cohort included 152 patients with Chiari malformation type I who received small-bone-window posterior fossa decompression at Beijing Tiantan hospital from January 2008 to September 2009. All patients underwent combined surgical procedures: a small-bone-window suboccipital decompression (diameter, 2.5-3 cm) and a C1 laminectomy (1.5- to 2-cm wide) followed by a duraplasty with an autologous graft. Clinical manifestations, radiologic features, and follow-up data during a 6-year span were analyzed. Risk factors associated with outcome were investigated by the use of χ(2) analysis and logistic regression analysis.
RESULTS: The average follow-up duration was 74 months. Symptoms were improved in 126 patients (82.9%), remained stable in 21 patients (13.8%), and deteriorated in 5 patients (3.3%). There was no mortality. Postoperative magnetic resonance imaging scans were available for all patients. Preoperatively, 112 patients were associated with syringomyelia, and the follow-up magnetic resonance images showed obvious reduction of syringomyelia in 73 patients (65.2%) and no significant change in 39 patients (34.8%). In addition, enlargement of the cistern magna was observed in 92 patients (85.2%). Regression analysis indicates preoperative motor dysfunction, brainstem herniation and basilar invagination may influence the clinical outcome (P < 0.05).
CONCLUSIONS: Small-bone-window posterior fossa decompression with duraplasty is an effective and safe treatment option with a low complication rate. Motor dysfunction, brainstem herniation, and basilar invagination are predictors of poor clinical prognosis.
PMID: 25701768 [PubMed - indexed for MEDLINE]
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Δευτέρα 11 Ιανουαρίου 2016
Effect of 90° counterclockwise rotation of the endotracheal tube on its advancement through the larynx during nasal fiberoptic intubation in children: a randomized and blinded study.
Effect of 90° counterclockwise rotation of the endotracheal tube on its advancement through the larynx during nasal fiberoptic intubation in children: a randomized and blinded study.
Paediatr Anaesth. 2016 Jan 7;
Authors: Choudhry DK, Brenn BR, Lutwin-Kawalec M, Sacks K, Nesargi S, He Z
Abstract
BACKGROUND: Resistance to the passage of the endotracheal tube (ETT) is frequently encountered in children as it is advanced over the fiberoptic scope for placement into the trachea because it gets hung up at the laryngeal inlet. Literature in adults indicates that a 90° counterclockwise rotation (CCR) of the ETT before advancing results in smooth passage. We found no literature in children.
OBJECTIVES: Our aim was to study if a 90° counterclockwise rotation (CCR) of the ETT before advancement leads to smooth passage of the ETT into the larynx in children.
METHODS: Following IRB approval, we performed this study in two parts: Part 1: An unblinded, observational, pilot study on 20 children scheduled for oral rehabilitation where we concurrently used a fiberoptic scope nasally and GlideScope orally. We visualized the ETT path and observed that 90° CCR allowed smooth passage without hang up. Part 2: A blinded and randomized study on 40 children to confirm if 90° CCR from the outset would improve passage of the ETT during nasal intubation with a fiberoptic scope in children. All children were divided into two groups: group S, ETT bevel facing left; group R, ETT bevel facing down.
RESULTS: In Part 1, we observed that the ETT got hung up in 57% of children with standard bevel direction (facing left) and in 0% of children when prerotated. In Part 2, efficacy of prerotation was confirmed; the ETT got hung up in 50% of children in group S but in only 10.5% of children in group R.
CONCLUSION: A change in ETT tip orientation from bevel facing left to facing down by 90° CCR, leads to a significantly higher first-attempt success rate by nasal approach in children. We believe the ETT should be rotated before insertion into the nostril to ensure that full 90° CCR of the tip has been accomplished.
PMID: 26749187 [PubMed - as supplied by publisher]
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Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.
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Therapeutic antibodies reveal Notch control of transdifferentiation in the adult lung.
Nature. 2015 Dec 3;528(7580):127-31
Authors: Lafkas D, Shelton A, Chiu C, de Leon Boenig G, Chen Y, Stawicki SS, Siltanen C, Reichelt M, Zhou M, Wu X, Eastham-Anderson J, Moore H, Roose-Girma M, Chinn Y, Hang JQ, Warming S, Egen J, Lee WP, Austin C, Wu Y, Payandeh J, Lowe JB, Siebel CW
Abstract
Prevailing dogma holds that cell-cell communication through Notch ligands and receptors determines binary cell fate decisions during progenitor cell divisions, with differentiated lineages remaining fixed. Mucociliary clearance in mammalian respiratory airways depends on secretory cells (club and goblet) and ciliated cells to produce and transport mucus. During development or repair, the closely related Jagged ligands (JAG1 and JAG2) induce Notch signalling to determine the fate of these lineages as they descend from a common proliferating progenitor. In contrast to such situations in which cell fate decisions are made in rapidly dividing populations, cells of the homeostatic adult airway epithelium are long-lived, and little is known about the role of active Notch signalling under such conditions. To disrupt Jagged signalling acutely in adult mammals, here we generate antibody antagonists that selectively target each Jagged paralogue, and determine a crystal structure that explains selectivity. We show that acute Jagged blockade induces a rapid and near-complete loss of club cells, with a concomitant gain in ciliated cells, under homeostatic conditions without increased cell death or division. Fate analyses demonstrate a direct conversion of club cells to ciliated cells without proliferation, meeting a conservative definition of direct transdifferentiation. Jagged inhibition also reversed goblet cell metaplasia in a preclinical asthma model, providing a therapeutic foundation. Our discovery that Jagged antagonism relieves a blockade of cell-to-cell conversion unveils unexpected plasticity, and establishes a model for Notch regulation of transdifferentiation.
PMID: 26580007 [PubMed - indexed for MEDLINE]
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Geographic variation in human papillomavirus-related oropharyngeal cancer: Data from four multinational randomized trials.
Geographic variation in human papillomavirus-related oropharyngeal cancer: Data from four multinational randomized trials.
Head Neck. 2016 Jan 8;
Authors: Mehanna H, Franklin N, Compton N, Robinson M, Powell N, Biswas-Baldwin N, Paleri V, Hartley A, Fresco L, Al-Booz H, Junor E, El-Hariry I, Roberts S, Harrington K, Ang KK, Dunn J, Woodman C
Abstract
BACKGROUND: There are variations in the proportions of head and neck cancers caused by the human papillomavirus (HPV) between countries and regions. It is unclear if these are true variations or due to different study designs and assays.
METHODS: We tested formalin-fixed paraffin-embedded diagnostic biopsies for p16 immunohistochemistry and HPV-DNA (by polymerase chain reaction [PCR] and in situ hybridization [ISH]) using validated protocols on samples from 801 patients with head and neck cancer recruited prospectively between 2006 and 2011 in 4 randomized controlled trials (RCTs).
RESULTS: Twenty-one percent of patients (170 of 801) showed both HPV-DNA and p16-positivity, detected almost exclusively in oropharyngeal cancer (55%; 15 of 302); and only 1% of the patients (5 of 499) with nonoropharyngeal cancer were HPV positive. HPV-positive oropharyngeal cancer differed between Western and Eastern Europe (37%, 155 of 422 vs 6%, 8 of 144; p < .0001) and between Western Europe and Asia (37% vs 2%; 4 of 217; p < .0001). Other independent determinants of HPV positivity were tumor site and smoking.
CONCLUSION: This is the first study to establish geographic variability as an independent risk factor in HPV-positive oropharyngeal cancer prevalence, with higher prevalence in Western Europe. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck, 2016.
PMID: 26749143 [PubMed - as supplied by publisher]
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