Radioactive iodine dose and survival in cats with hyperthyroidism (2015-2020)

xlomafota13 shared this article with you from Inoreader Radioactive iodine dose and survival in cats with hyperthyroidism (2015-2020) Via radioactive iodine J Feline Med Surg. 2021 Nov 3:1098612X211056837. doi: 10.1177/1098612X211056837. Online ahead of print. ABSTRACT OBJECTIVES: Radioactive iodine (131I) is the preferred treatment for feline hyperthyroidism but neither the optimal 131I dose nor consistent predictors of post-treatment azotaemia have been determined. The aims of the study were to evaluate the relationships between: (1) 131I dose and survival; and (2) pretreatment and post-treatment seru m creatinine concentration. METHODS: Medical records of hyperthyroid cats treated with 131I at a single referral hospital were reviewed. Information regarding signalment, body weight, pretreatment and post-treatment serum total thyroxine concentration (TT4), serum creatinine concentration, 131I dose and survival were determined. Multivariable Cox proportional hazards analysis was used to identify variables associated with survival. Multivariable linear regression analysis was used to identify variables associated with post-treatment serum creatinine concentration. RESULTS: One hundred and ninety-eight (79 male, 119 female) cats were treated for hyperthyroidism with 131I (median dose 138 MBq; interquartile range 92-168). Median survival time was 1153 days (range 16-1871). Post-treatment serum creatinine (P <0.001) and age (P = 0.049) were significantly associated with survival. Every 10 µmol/l increase in post-treatment s erum creatinine concentration and every year increase in age was associated with a 1.07 fold (confidence interval [CI] 1.04-1.11) and 1.17-fold (CI 1.00-1.37) increase in the daily hazard of death, respectively. Pretreatment serum creatinine concentration was directly, and post-treatment serum TT4 concentration was inversely, associated with post-treatment serum creatinine concentration. Every 1 μmol/l increase in pretreatment serum creatinine concentration was associated with an increase in post-treatment serum creatinine concentration of 0.7 μmol/l (SE 0.17; P <0.001). Conversely, every 1 nmol/l decrease in post-treatment serum TT4 concentration was associated with a 1.2 μmol/l (SE 0.61; P <0.001) increase in post-treatment serum creatinine concentration. CONCLUSIONS AND RELEVANCE: Post-treatment serum TT4 concentration was associated with post-treatment azotaemia, which was associated with survival. Although 131I dose was not directly assoc iated with survival, dosing strategies that minimise post-treatment hypothyroidism and azotaemia could improve patient survival. PMID:34730466 | DOI:10.1177/1098612X211056837 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

New Drug Approvals

• Scemblix (asciminib) Tablets

  Date of Approval: October 29, 2021
  Treatment for: Chronic Myelogenous Leukemia
  Press Release | Approval History

• Vuity (pilocarpine hydrochloride) Ophthalmic Solution

  Date of Approval: October 28, 2021
  Treatment for: Presbyopia
  Press Release | Approval History

• Susvimo (ranibizumab) Injection for Intravitreal Use via Ocular Implant

  Date of Approval: October 25, 2021
  Treatment for:
  Press Release | Approval History

• Xipere (triamcinolone acetonide) Injection

  Date of Approval: October 22, 2021
  Treatment for: Macular Edema, Uveitis
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• Zimhi (naloxone hydrochloride) Injection

  Date of Approval: October 15, 2021
  Treatment for: Opioid Overdose
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• Seglentis (celecoxib and tramadol hydrochloride) Tablets

  Date of Approval: October 15, 2021
  Treatment for: Pain
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• Tyrvaya (varenicline) Nasal Spray

  Date of Approval: October 15, 2021
  Treatment for: Dry Eye Disease
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• Rethymic (allogeneic processed thymus tissue-agdc) for Surgical Implantation

  Date of Approval: October 8, 2021
  Treatment for: Congenital Athymia
  Press Release | Approval History

• Tavneos (avacopan) Capsules

  Date of Approval: October 7, 2021
  Treatment for: ANCA-Associated Vasculitis
  Press Release | Approval History

Association between diabetes mellitus and chronic rhinosinusitis with nasal polyps: a population‐based cross‐sectional study

xlomafota13 shared this article with you from Inoreader Association between diabetes mellitus and chronic rhinosinusitis with nasal polyps: a population‐based cross‐sectional study Via Clinical Otolaryngology ABSTRACT Objective To investigate the association between physician-diagnosed diabetes mellitus (DM) and chronic rhinosinusitis (CRS) phenotypes in a national population-based study. Study Design Retrospective cross-sectional study. Setting Population-based survey data collected by the Korean National Health and Nutrition Survey between January 2008 and December 2012. Participants and Methods A total of 34,670 participants aged over 19 years were enrolled in the Korea National Health and Nutrition Examination Surveys from 2008 to 2012. The relationship of CRS prevalence, with and without nasal polyps, with physician-diagnosed DM and non-DM were assessed. Differences in sinonasal symptoms between patients with and without DM were analyzed in this cross-sectional study. Results A significant association was observed between DM and CRS with nasal polyps after adjustment for multiple variables. No substantial association was observed between DM and CRS without nasal polyps. Among patients with CRS, olfactory dysfunction for >3 months was significantly more frequent in the DM group than in the non-DM group. Conclusion We demonstrated significant associations between DM and CRS with nasal polyps and olfactory dysfunction among patients with CRS in a large national clinical cohort study. The direct mechanism of the association between DM and CRS with nasal polyps should be further investigated to clarify the pathogenesis of CRS with nasal polyps. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Anterior cruciate ligament innervation in primary knee osteoarthritis

xlomafota13 shared this article with you from Inoreader Anterior cruciate ligament innervation in primary knee osteoarthritis Via Cellular and Molecular Biology Histol Histopathol. 2021 Nov 2:18389. doi: 10.14670/HH-18-389. Online ahead of print. ABSTRACT OBJECTIVE: To relate the Anterior Cruciate Ligament (ACL) innervation and histologic degeneration status to the knee osteoarthritis radiologic and functional status. DESIGN: Prospective observational study including 30 consecutive patients affected by primary knee osteoarthritis undergoing Total Knee Arthroplasty (TKA). All patients suffering secondary knee osteoarthritis, an antecedent of an infectious process, malignant process, autoimmune disorder, or previous knee surgery were excluded. We recorded biodemographic, clinical, and radiologic variables of all participants previous to the TKA procedure. ACL tissue was harvested during TKA standard procedure and the obtained sample was fixed in 4% formalin and paraffin-embedded. ACL cross-sections were stained by haematoxylin-eosin and Gallego staining for elastic and collagen fibers, and Sevier-Munger silver staining for nervous tissue. RESULTS: ACL samples histologic degeneration classification reported 15.4% normal, 23.1% slight, 26.9% mild, 11.5% moderate and 23.1% marked. We noted 46.2% large nervous fascicles, 15.4% medium fascicles, 3.8% small fascicles, and no nerve fibers were found in 34.6% ACL samples. No significant correlation was found between the histologic degeneration and the nervous fiber quantification (p>0.05, in all cases). We noted a significant histologic degeneration inverse correlation with the VAS scale (p=0.016), and nervous fiber quantification correlation with Lequesne maximum distance walked punctuation (p=0.043). We also noted greater nervous fiber quantification with minor radiological knee osteoarthritis (Kellgren-Lawrence grade II). CONCLUSIONS: ACL degeneration and innervation deficit may play a role in primary knee osteoarthritis onset, but the lack of a defining relationship among the different parameters assessed justifies further research in greater populations. PMID:34725806 | DOI:10.14670/HH-18-389 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Cutoff Age Between Pediatric and Adult Thyroid Differentiated Cancer: Is 18 Years Old Appropriate?

xlomafota13 shared this article with you from Inoreader Cutoff Age Between Pediatric and Adult Thyroid Differentiated Cancer: Is 18 Years Old Appropriate? Via liebertpub1 Thyroid, Ahead of Print. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Posttraumatic Vernet syndrome without fracture: A case report and short literature review

xlomafota13 shared this article with you from Inoreader Posttraumatic Vernet syndrome without fracture: A case report and short literature review Via swallowing exercises Medicine (Baltimore). 2021 Oct 29;100(43):e27618. doi: 10.1097/MD.0000000000027618. ABSTRACT RATIONALE: The aim of this case is to emphasize the need to include nerve traction in the differential diagnosis of nerve deficits associated with Vernet syndrome. This mechanism of injury has been described only once, but must not be overlooked and should be considered and included as a possible cause in diagnostic algorithms. PATIENT CONCERNS: A patient presenting with dysphagia, ex treme hoarseness, and limited shoulder movement after head injury was admitted to the emergency department. DIAGNOSES: Multidisciplinary evaluation was performed, and nerve traction-induced Vernet syndrome was established as a running diagnosis. INTERVENTIONS: Intensive swallowing and speech exercises, assisted by a specialist, were performed. OUTCOMES: Swallowing and speech exercises significantly and objectively improved the patient's swallowing and voice, with mild hoarseness of voice remaining as the main symptom. Spectral acoustic analysis went from a voice pitch of 163.77 Hz to normal (187.77 Hz), jitter improved from 17.87% to 0.86% and shimmer values decreased from 39.86% to 19.60%. Breathiness during phonation measuring 2.91% was reduced to 1.08% and appropriate average intensity of voice (63.95 dB) was achieved. Initial dysphagia and fluid retention in the right piriform sinus, along with tracheal aspiration, were not observed in control fiberoptic endosc opic evaluation of swallowing. LESSONS: According to our knowledge and literature data, this is the second reported case of posttraumatic Vernet syndrome without radiologically confirmed jugular foramen fracture, induced by nerve traction. Such patients need a prompt multidisciplinary approach in diagnosis and timely posttraumatic rehabilitation therapy for favorable clinical evolution and retrieval of nerve function. PMID:34713846 | DOI:10.1097/MD.0000000000027618 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Risk factors for postoperative cerebrospinal fluid leakage after transsphenoidal surgery for pituitary adenoma: a meta-analysis and systematic review

xlomafota13 shared this article with you from Inoreader Risk factors for postoperative cerebrospinal fluid leakage after transsphenoidal surgery for pituitary adenoma: a meta-analysis and systematic review Via leak of cerebrospinal fluid BMC Neurol. 2021 Oct 27;21(1):417. doi: 10.1186/s12883-021-02440-0. ABSTRACT OBJECTIVE: Postoperative cerebrospinal fluid (CSF) leakage represents a challenge even for experienced pituitary surgeons. We aimed to quantitatively synthesize data from studies regarding the risk factors for postoperative CSF leakage after transsphenoidal surgery (TSS) for pituitary adenoma (PA). METHODS: PubMed, Web of Science, The Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang database, and VIP database were searched for case-control and cohort studies, focusing on the risk factors associated with postoperative CSF leakage after TSS for PA. Pooled odds ratios (ORs) and 95% confidence intervals were calculated to determine the risk factors. RESULTS: A total of 34 case-control and cohort studies involving a total of 9,144 patients with PA were included in this systematic review. The overall rate of postoperative CSF le akage after TSS for PA was 5.6%. Tumor size, adenoma consistency, revision surgery, and intraoperative CSF leakage were independent risk factors for postoperative CSF leakage (ORs, 3.18-6.33). By contrast, the endoscopic approach showed a slight protective benefit compared with the microscopic approach in TSS (OR, 0.69). CONCLUSIONS: This review provides a comprehensive overview of the quality of the evidence base, informing clinical staff of the importance of screening risk factors for postoperative CSF leakage after TSS for PA. More attention should be paid to PA patients at high risk for CSF leakage after TSS to reduce complications and improve prognosis. PMID:34706659 | DOI:10.1186/s12883-021-02440-0 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Woodruff's plexus-arterial or venous?

xlomafota13 shared this article with you from Inoreader Woodruff's plexus-arterial or venous? Via radiol anat Surg Radiol Anat. 2021 Oct 29. doi: 10.1007/s00276-021-02852-0. Online ahead of print. ABSTRACT PURPOSE: Woodruff's plexus is a vascular network located on the posterior lateral wall of the inferior meatus of the nasal cavity and it is generally considered to be responsible for posterior epistaxis. Despite being initially identified in 1949 as a venous plexus, discrepancies exist within literature regarding this anatomical structure, particularly its arterial or venous natur e and its association with posterior epistaxis. This systematic review aims to collate information pertaining to Woodruff's plexus and evaluate our current understanding of this vascular area. METHODS: The systematic review was performed using published data in PubMed, Google Scholar, Scopus, EBSCO and Web of Science platforms using keywords such as 'Woodruff', 'posterior' and 'plexus'. Articles referring to Woodruff's plexus were collected and analysed by independent reviewers. RESULTS: The search revealed 154 papers, out of which only 40 were included in the review. Out of this number only two papers were anatomical dissection studies, both of which identify the plexus as venous in nature. Seventeen studies describe the plexus as venous by citing these two papers. The remainder of the articles (23) consider Woodruff's plexus as arterial with variability in the reported arteries that supply it. CONCLUSION: Woodruff's original description of a venous plexus is supp orted by modern anatomical studies. There are a multitude of reports that Woodruff's plexus is arterial in nature, despite the absence of existing anatomical studies to support this notion. This misconception has likely arisen due to clinical associations in relation to posterior epistaxis. PMID:34714375 | DOI:10.1007/s00276-021-02852-0 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Post-operative clinical course in children undergoing mastoidectomy due to complicated acute mastoiditis

xlomafota13 shared this article with you from Inoreader Post-operative clinical course in children undergoing mastoidectomy due to complicated acute mastoiditis Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Oct 29. doi: 10.1007/s00405-021-07149-x. Online ahead of print. ABSTRACT PURPOSE: To determine the immediate post-operative course and outcome of pediatric patients with complicated acute mastoiditis (CAM) following surgical treatment. METHODS: A retrospective chart review of children diagnosed with CAM who underwent mastoid surgery during 2012-2019 in a tertiary care university hospital. 33 patients, divided into 2 groups: 17 patients with sub-periosteal abscess (SPA) alone-single complication group (SCG) and 16 patients with SPA and additional complications: sigmoid sinus thrombosis (SST), peri-sinus fluid/abscess, epidural/subdural abscess, and acute meningitis-multiple complications group (MCG). RESULTS: 33 patients belong to the SCG 17(51%) and 16(49%) belonged to the MCG, respectively. 6/17(35.3%) SCG patients experienced POF vs. 12/16(75%) in the MCG (P = 0.012). At post-operative day 2 (POD2), 10/13(77%) febrile patients belonged to MCG and 3/13(23%) to SCG (P = 0.013). POF was recorded until POD6 in both groups. Seven patients, all from MCG with POF, underwent second imaging with no new findings; a total of 18 positive cultures were reported. Fusobacterium necrophorum counted for 8/18(44.5%) of all positive cultures, 7/9(77.8%) in the MCG vs. 1/9(11.1%) in the SCG, P = 0.004. Streptococcus pneumoniae was reported only in SCG (5/9, 55.5%, vs. 0/9, P = 0.008). CONCLUSION: Post-mastoidectomy fever due to CAM is not unusual and seems to be a benign condition for the first 5-6 days, following surgery. MCG patients are more prone to develop POF. F. necrophorum is more likely to be associated with MCG, and S. pneumoniae is common in SCG patients. PMID:34714371 | DOI:10.1007/s00405-021-07149-x View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Electrically Induced Blink for the Prevention of Ocular Symptoms and Blurred Vision in Patients With Acute Facial Nerve Palsy

xlomafota13 shared this article with you from Inoreader Electrically Induced Blink for the Prevention of Ocular Symptoms and Blurred Vision in Patients With Acute Facial Nerve Palsy Via ear nose throat Ear Nose Throat J. 2021 Oct 29:1455613211048576. doi: 10.1177/01455613211048576. Online ahead of print. ABSTRACT Objectives: Facial nerve palsy causes blurred vision and ocular discomfort due to deficits in blinking and eye closure. The objective of this study was to determine whether eye-blinks could be elicited by electrical stimulation and whether electrically induced blink would have an effect on the visual acuity and ocular symptoms in patients with acute facial nerve palsy. Methods: The zygomatic branch of the facial nerve of fifteen participants with acute facial nerve palsy was electrically stimulated in order to elicit a blink. In successful cases, the participant proceeded with a two-hour TV watching session in which an electrically induced blink was delivered every 5 seconds. The control condition consisted of an otherwise similar TV watching session without electrically induced blinking. Subjective ocular symptoms were evaluated with a Dry Eye Questionnaire and visual acuity was assessed with a Logarithm of the Minimum Angle of Resolution (LogMAR) chart before and after both sessions. Results: The stimulation produced a blink in 8 participants (53%). The visual acuity in the affected eye decreased during the control session, whereas no significant change occurred during the stimulation session. The ocular symptoms were significantly reduced during the stimulation session. Conclusions: Electrically elicited blink is a promising method for reducing the eye symptoms in individuals with acute facial nerve palsy. PMID:34714168 | DOI:10.1177/01455613211048576 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Extensive Parapharyngeal Abscess in a 4-Month-Old Infant

xlomafota13 shared this article with you from Inoreader Extensive Parapharyngeal Abscess in a 4-Month-Old Infant Via ear nose throat Ear Nose Throat J. 2021 Oct 29:1455613211049854. doi: 10.1177/01455613211049854. Online ahead of print. ABSTRACT Parapharyngeal abscess in an infant is a very rare condition. We present the case of a 4-month-old girl with large masses on the neck's left side. Computed tomography showed an extensive parapharyngeal abscess. Left tonsillectomy was performed under general anesthesia from a transoral approach, followed by an incision and evacuation of the abscess from the parapha ryngeal space. Microbiological analysis identified a massive occurrence of Streptococcus intermedius. PMID:34714174 | DOI:10.1177/01455613211049854 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.