OtoRhinoLaryngology News

Σάββατο 31 Οκτωβρίου 2015

Correlation of Otorhinolaryngologic Symptoms with Physical Findings in Behçet's Disease.

Correlation of Otorhinolaryngologic Symptoms with Physical Findings in Behçet's Disease.

B-ENT. 2015;11(1):31-7

Authors: Meric A, Dogan R, Su O, Eren SB, Tugrul S, Ozturan O

Abstract
OBJECTIVE: Behçet's disease is a chronic systemic inflammatory disease of unknown etiology. We examined the correlation between otorhinolaryngologic symptoms and otorhinolaryngologic physical findings in patients with Behçet's disease, in search of strategies to reduce the morbidity rates.
METHODS: Seventy-two patients diagnosed with Behçet's disease were included. After giving a detailed history of oropharyngeal, nasal, laryngeal, and otic symptoms, patients were examined endoscopically by an otolaryngologist, and the findings were recorded.
RESULTS: Thirty-nine of the patients were male, and thirty-three were female. The mean age was 39.2 ± 3.4, and the mean disease duration was 8.24 ± 4.2 years. Statistically significant correlations were observed between ear lesions and ear symptoms (crusting and otic pain), nasal lesions and nasal symptoms (crusting and nasal pain), oropharyngeal lesions and oropharyngeal symptoms (pain and difficulty in swallowing), and laryngeal lesions and laryngeal symptoms (hoarseness, difficulty in swallowing, and pain).
CONCLUSION: The results demonstrated a positive correlation between symptoms and otorhinolaryngeal examination findings in Behçet's disease. Potential morbidities can be prevented by routine endoscopic otorhinolaryngeal examinations and symptom screening of patients with Behçet's disease and arranging the therapy accordingly.

PMID: 26513945 [PubMed - in process]

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The relationship between serum urea levels and outcome in acute epistaxis.

The relationship between serum urea levels and outcome in acute epistaxis.

B-ENT. 2015;11(1):25-9

Authors: Fishpool SJ, Foley K, Bul S, Whittet H

Abstract
OBJECTIVES: To establish whether, for the patient presenting with epistaxis, there is a relationship between clinical outcome and serum urea levels measured on initial attendance at the accident and emergency (A&E) department.
METHODOLOGY: Records were reviewed from all patients attending a single teaching hospital A&E department between 1st January 2010 and 11st February 2011 with a diagnosis of epistaxis. Patients were analysed according to their admission serum urea and creatinine levels and then grouped according to clinical outcome.
RESULTS: We identified 278 patients (145 males, 133 females), 82 of which required hospital admission. Eleven required blood transfusion, and five required surgical arrest of the haemorrhage. No patients died. Serum urea and creatinine levels were measured in 119/278 patients. The mean serum urea level was significantly higher in patients admitted for further management of epistaxis than in patients who were discharged from the A&E department (9.35 mmol/l vs. 6.74 mmol/l, respectively; p = 0.003). There was no significant difference in mean serum urea levels between patients who were transfused and patients who were not, or between patients who went to the operating theatre and patients who did not.
CONCLUSIONS: Elevated serum urea levels on hospital admission are related to more severe clinical outcome in epistaxis.

PMID: 26513944 [PubMed - in process]

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Preoperative anxiety and postoperative pain in patients undergoing septoplasty.

Preoperative anxiety and postoperative pain in patients undergoing septoplasty.

B-ENT. 2015;11(1):19-23

Authors: Ocalan R, Akin C, Disli ZK, Kilinc T, Ozlugedik S

Abstract
OBJECTIVE: The aim of the study was to determine whether psychological variables such as preoperative anxiety could serve as predictors of the postoperative pain response.
METHODS: Sixty consecutive patients with deviated nasal septum were evaluated in the pre- and postoperative periods. A questionnaire that included sociodemographic features was administered to patients. Preoperative anxiety was assessed by the Spielberger State-Trait Anxiety Index. The severity of pain was recorded with a ten-point Visual Analog Scale at the immediate postoperative period (baseline) and at postoperative hours 2, 4, 6, 12, and 24.
RESULTS: Sixty patients met the eligibility criteria for the study. Of the 60 patients (39 men and 21 women) whose charts were reviewed, the mean age was 30.9 ± 12.6 years for men and 32.8 ± 10.4 years for women. The mean State-Trait Anxiety Index score was 44.3 ± 7.5 (range 29-67). No significant relationship was found between the patients' self-reports of postoperative pain and sociodemographic variables such as age and educational status. Men and women showed significant differences with respect to pain in the immediate and late postoperative periods. Correlation tests identified a significant relationship between patients' preoperative anxiety and postoperative pain in both the immediate and late periods.
CONCLUSIONS: The results of this study suggest that early interventions to minimize the preoperative anxiety stress response may affect the postoperative pain response.

PMID: 26513943 [PubMed - in process]

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Rupatadine relieves allergic rhinitis: a prospective observational study.

Rupatadine relieves allergic rhinitis: a prospective observational study.

B-ENT. 2015;11(1):11-8

Authors: Eloy P, Tobback L, Imschoot J

Abstract
BACKGROUND: Allergic rhinitis has reached epidemic levels for years in Belgium and substantially impacts the quality of life of patients. Observational, non-interventional studies can provide valuable data, supplementing findings from double-blind trials, on the true value of a drug therapy in daily practice. Rupatadine is a new, second-generation, selective oral H1-antihistamine. The primary objective of.this study was to evaluate the evolution of quality of life in patients treated with rupatadine in clinical practice. The impact of rupatadine on the severity of allergic rhinitis symptoms, the subject's evaluation of the treatment, and the safety of rupatadine were also evaluated.
METHODS: This prospective, non-interventional, observational, multicenter study included 2,838 adults aged over 18 years. The diagnosis of moderate to severe allergic rhinitis was confirmed. Patients were assessed with validated scales at baseline and after 6 weeks of treatment with rupatadine (10 mg, once daily).
RESULTS: All outcome parameters improved significantly: mini-rhinoconjunctivitis quality of life questionnaire (mini- RQLQ, p < 0.001), total 5-symptom score (T5SS) severity (p < 0.001), visual analog scale (VAS) of symptom severity (p < 0.001), and the allergic rhinitis and its impact on asthma (ARIA) severity classification (p < 0.001). Compliance was very good in 72.2% of patients, and only a few minor adverse effects were reported. The therapeutic responses, evaluated by the patients, were complete relief in 21% and strong relief in 62%.
CONCLUSION: This study, which included a wide cohort of allergic-rhinitis patients, confirmed the clinical benefit of rupatadine when prescribed in clinical practice, even for the most severe symptoms, including nasal congestion.

PMID: 26513942 [PubMed - in process]

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Recruitment and activation of circulating neutrophils after sinus surgery.

Recruitment and activation of circulating neutrophils after sinus surgery.

B-ENT. 2015;11(1):1-10

Authors: Watelet JB, Chatelain B, Eloy P, Dogne JM, Mullier F

Abstract
OBJECTIVE: After failure of pharmacological treatment, sinus surgery is the recommended alternative treatment for chronic sinusitis with or without nasal polyps. During post-operative healing, adequate local neutrophil activation plays an important role in the repair process. This pilot study aimed to systematically explore the participation of circulating neutrophils in early-phase wound repair of the nasal and paranasal mucosa after sinus surgery, with a special focus on neutrophil recruitment and activation patterns.
METHODOLOGY: We conducted a single-center outcome study of patients undergoing sinus surgery. Whole blood samples were collected from eleven patients before surgery and at post-surgical time points of 1 hour and 1, 7, 14, and 30 days. Hematological analysis was conducted to count circulating neutrophils and evaluate their overall activation status. Using flow cytometry, neutrophil expression of membrane CD11b, CD11c, and CD15 was also measured, and oxidative burst analysis was performed.
RESULTS: After sinus surgery, neutrophilia increased by 1 hour after surgery, reached a maximum at Day 1, and showed a gradual return toward baseline by Day 30. The oxidative burst initially decreased during the first hours after surgery, increased at Day 14, and returned toward normal by Day 30. Lewis X factor and the expression of CD11b and CD11c exhibited a bimodal change over time, in an inverted phase compared to the oxidative reaction.
CONCLUSIONS: Circulating neutrophils are involved in the first phase of wound healing after sinus surgery as indicated by increased abundance, early membrane changes, and the modulation of their oxidative capacities.

PMID: 26513941 [PubMed - in process]

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[The research status of probiotic treatment of allergic rhinitis].

[The research status of probiotic treatment of allergic rhinitis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1140-2

Authors: Qiao W, Feng K, Luo Q

Abstract
Allergic rhinitis is nasal mucosa of immediate hypersensitivity, and the current treatment is not satisfied. With the increasing incidence in recent years, we pay more attention on the effective treatments. There are some published studies indicate the benefit of probiotic for allergic rhinitis. Refer to the related literature in recent years, the paper will discuss probiotic species, safety, route of administration, mechanism and efficacy, pointing out a new direction for the treatment of allergic rhinitis.

PMID: 26514016 [PubMed - in process]

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[One case of human nasal myiasis].

[One case of human nasal myiasis].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1138-9

Authors: Su H, Liu L, Zhao Y

Abstract
Human myiasis is caused by the parasitic maggots of flies. We report a case of nasal myiasis in a 37-year-old woman in Henan. The patient presented with nasal foreign-body sensation, nansal itching sneezing, snuffle and such allergic symptoms in nasal cavity. Based on maggots that were bowed from the right nasal cavity, a detailed endoscopic examination, sinus CT scan and identification of the maggot's species done by parapsychologists of the parasitology teaching and reseach section of the Zhengzhou University School of Medicine, the diagnosis of human nasal infestation by oestrus ovis was definited.

PMID: 26514015 [PubMed - in process]

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[Pyogenic granuloma of inferior turbinate: a case report].

[Pyogenic granuloma of inferior turbinate: a case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1137-8

Authors: Zhang S, Liu Y, Jiang Z

Abstract
A case of pyogenic granuloma occurred in inferior turbinate was reported and the literatures were reviewed. A 32 years old male patient with left side progressive stuffy nose and repeated epistaxis. Nasal endoscopic examination showed a dark red neoplasm in left nasal cavity and blocked the anterior naris. Nasal cavity enhanced CT showed the neoplasm located in the front of left nasal cavity with marked enhancement. Bilateral sinuses were normal and there was no significant bone destruction. Nasal endoscopic surgery was performed under local anesthesia. Postoperative pathology report showed pyogenic granuloma (granulation tissue type of angioneoplasm).

PMID: 26514014 [PubMed - in process]

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[Digestive system carcinoma metastatic to the nasal cavity: two case report].

[Digestive system carcinoma metastatic to the nasal cavity: two case report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1134-6

Authors: Wang W, Ying L, Zhu Z

Abstract
Metastatic tumors to the nasal cavity and paranasal sinuses are far less common than primary cancer in this location. The digestive system malignant tumor metastasis to the nose is rarer. The clinical presentation of metastases is similar to that of primary tumors and common symptoms include recurrent epistaxis, nasal obstruction and facial pain. Metastases to the nose and paranasal sinuses usually respond poorly to treatment and have a poor prognosis.

PMID: 26514013 [PubMed - in process]

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[Nasopharynx pleomorphic adenoma report].

[Nasopharynx pleomorphic adenoma report].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1133-4

Authors: Liu X, Zhang Q, She C

Abstract
The patient was a 42 years old female. And the reason why she was addmited to the hospital was progressive bilateral nasal congestion for one year, and bilateral nasal bleeding for one day. Physical examination showed no surgical contraindication so the patient got the nasal endoscope by plasma radiofrequency ablation surgery with general anesthesia on 3rd Dec. 2013. And the result of potholegical examination was nasopharynx pleomorphic adenoma.

PMID: 26514012 [PubMed - in process]

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[A case report of endoscopic assisted unilateral infraorbital nerve decompression].

[A case report of endoscopic assisted unilateral infraorbital nerve decompression].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1131-2

Authors: Chen Y, An Y, Zhao C

Abstract
Patients of infraorbital nerve injury often appear in the sensory abnormalities of corresponding position, such as numbness or pain. We present a case with numbness of the left cheek because of the injury. The patient were treated by endoscopic assisted on the left infraorbital nerve decompression through the approach of the canine fossa. The symptom shows improvement after the operation. The patient feels numbness significantly ease on 4 months after the operation.

PMID: 26514011 [PubMed - in process]

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[Intranasal endoscopic coblation exairesis for nasal vestibular cyst].

[Intranasal endoscopic coblation exairesis for nasal vestibular cyst].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1129-30

Authors: Wang X, Zhang H, Li Z

PMID: 26514010 [PubMed - in process]

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[The extraction of foreign body in nasal sinus and bases of skull: craniotomy or not?].

[The extraction of foreign body in nasal sinus and bases of skull: craniotomy or not?].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1127-9

Authors: Fu Z, Wang S, Zhang Y

PMID: 26514009 [PubMed - in process]

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[The application of expandible and soluble chitosan sponge in patients with the disease of haematology nasal bleeding].

[The application of expandible and soluble chitosan sponge in patients with the disease of haematology nasal bleeding].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1126-7

Authors: Liu T, Ren S, Zhu X

PMID: 26514008 [PubMed - in process]

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[Effect of dexamethasone on the expression of Tregs in allergic rhinitis mice].

[Effect of dexamethasone on the expression of Tregs in allergic rhinitis mice].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1121-5

Authors: Jiang T, Wang W, Zhu Z, Zhu L, Ma Z

Abstract
OBJECTIVE: To investigate the effect of dxamethasone (DEX) on the expression of Tregs in allergic rhinitis (AR) mice, and explore the mechanism of glucocorticoid in the treatment of AR.
METHOD: AR murine model was established by sensitization and challenge with OVA, besides intervention treatment with DEX was carried out in AR model. The behavior observation was used to evaluate the improvement effect of DEX on AR symptoms. The morphological characteristics of nasal tissues were observed by HE staining after fixation and decalcification. The mononuclear cells were obtained by grinding spleens, and the total RNA was extracted for reverse transcriptase polymerase chain reaction to investigate the level of mRNA expression of Foxp3. The changes of CD4+ Foxp3+ Tcells in spleen of mice were analyzed by flow cytometry.
RESULT: BALB/c mice received OVA sensitization followed by OVA intranasal challenge, the frequencies of sneezing and nose-scratching increased significantly in AR group (44. 50 ± 5. 61 and 72. 94 ± 8. 76) compared with control group (12. 68 ± 1. 87 and 26. 76 ± .2. 89), P<0. 01; The frequencies decreased significantly in DEX group (26. 04 ± 3. 93 and 56. 79 ± 5. 64), P< 0. 05 compared with AR group. The continuity of nasal mucosa ciliated columnar epithelium in AR group was destroyed and appeared to be repaired in DEX group. Inflammatory cells infiltration was also markedly decreased by DEX treatment. The proportion of CD4+ Foxp3+ T cells in AR group (3. 89 ± 0. 39)% decreased, P<0. 01 vs control group (4. 63 ± 0. 15) %. DEX treatment induced production of Tregs (6. 89 ± 0. 49)%, P<0. 05 vs control group. DEX significantly increased the expression of Foxp3 mRNA (P<0. 05) compared with AR and control group.
CONCLUSION: DEX reduce upper airway allergic inflammation effectively, which may be mediated by promoting the expression of Foxp3 and inducing the amplification of Tregs in vivo.

PMID: 26514007 [PubMed - in process]

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[An in vitro study on substance P-stimulated neuro-immune mechanism of mast cell degranulation].

[An in vitro study on substance P-stimulated neuro-immune mechanism of mast cell degranulation].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1118-20

Authors: Li Q, Zhao C

Abstract
OBJECTIVE: The goal of this study was to study the mechanism of substance P (SP)-mediated the neural control of mast cell (MC) degranulation.
METHOD: Bone marrow mast cells from mice were cultured with stem cell factor (SCF), IL-3 and IL-4 (group A) and SCF, IL-3 (group B) for four weeks. Then the cells were harvested and reserved for studies. Western Blot hybridization technique was used to detect the expression of FcεR I α and NK-1R on MCs from the two groups. Then such cells were activated with SP (0, 0. 01, 0. 10, 1. 00, 10. 00 µg/ml, respectively) for 30 min. The histamine released into the supernatant and stored in the protoplasm was quantified by enzyme linked immunosorbent assay (ELISA). And the percentage of histamine release was calculated as a percent of total histamine content.
RESULT: The expressions of FcεR I α and NK-1R on these mast cells in group A were statistically higher than in group B (P<0. 05). The MCs from two groups can be actived when stimulated by SP, but the level of MC degranulation in group A was higher than group B (P<0. 05).
CONCLUSION: Neuropeptide may stimulate MC degranulation through immunological and non-immunological pathways. In summary, the current study provides us with better understanding of the mechanism of neuropeptide-controlled MC deranulation, and this should be helpful for the further research involved in the mechanism and treatmemt of airway hyper-reactivity.

PMID: 26514006 [PubMed - in process]

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[The clinical characters and surgical management of nasopharyngeal teratoma in infants].

[The clinical characters and surgical management of nasopharyngeal teratoma in infants].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1115-7

Authors: Xia F, Wang Z, Xu Z

Abstract
OBJECTIVE: To describe and analyze the clinical characteristics of nasopharyngeal teratoma in infants and improve the levels of diagnosis and treatment to reduce misdiagnosis.
METHOD: The clinical data of 11 cases of nasopharyngeal teratoma in infants were reviewed retrospectively and summarized the clinical features. After the preoperative examination of nasopharyngeal endoscopy and imaging (CT or MRI), all patients were under general anesthesia of nasopharyngeal teratoma surgical resection. Of them, 8 cases were used radiofrequency ablation, 3 cases used conventional power systems.
RESULT: Eleven cases with neoformation were completely removed, the operation time was 5-15 min, blood loss was 1-5 ml, patients had no significant nasal obstruction, bleeding, eating nasopharyngeal regurgitation, breathing difficulties or other complications. No recurrence was found after 10 months to 9 years followed up.
CONCLUSION: The nasopharyngeal mass must be kept in mind in the differential diagnosis of breathing difficulties in infants, especially when it exists together with upper airway obstruction symptoms; The low-temperature radiofrequency ablation with endoscopic had the advantages of short time, precise control, less bleeding, clear operative field, little injury and pain, low recurrence, providing a new clinical treatments.

PMID: 26514005 [PubMed - in process]

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[Study on the factors impacting on early cochlear implantation between the eastern and western region of China].

[Study on the factors impacting on early cochlear implantation between the eastern and western region of China].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1111-4

Authors: Xiao H, Li W, Ma R, Gong Z, Shi H, Li H, Chen B, Jiang Y, Dai C

Abstract
OBJECTIVE: To describe tne regional different factors which impact on early cochlear implantation in prelingual deaf children between eastern and western regions of China.
METHOD: The charts of 113 children who received the cochlear implantation after 24 months old were reviewed and analyzed. Forty-five of them came from the eastern region (Jiangsu, Zhejiang or Shanghai) while 68 of them came from the western region (Ningxia or Guizhou). Parental interviews were conducted to collect information regarding the factors that impact on early cochlear implantation. Result:Based on the univariate logistic regression analysis, the odds ratio (OR) value of universal newborn hearing screening (UNHS) was 5. 481, which indicated the correlation of UNHS with early cochlear implantation is significant. There was statistical difference between the 2 groups (P<0. 01). For the financial burden, the OR value was 3. 521(strong correlation) and there was statistical difference between the 2 groups (P<0. 01). For the communication barriers and community location, the OR value was 0. 566 and 1. 128 respectively, and there was no statistical difference between the 2 groups (P>0. 05). The multivariate analysis indicated that the UNHS and financial burden are statistically different between the eastern and western regions (P=0. 00 and 0. 040 respectively).
CONCLUSION: The UNHS and financial burden are statistically different between the eastern reinforced in the western region. In addition, the government and society should provide powerful policy and more financial support in the western region of China. The innovation of management system is also helpful to the early cochlear implantation.

PMID: 26514004 [PubMed - in process]

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[The long-term clinical efficacy of endoscopic surgery of primary sinonasal malignant neoplasms].

[The long-term clinical efficacy of endoscopic surgery of primary sinonasal malignant neoplasms].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1105-10

Authors: Ye Y, Qiu Q, Zhang S, Huang Y, Zhan J, Xu M

Abstract
OBJECTIVE: To assess the long-term clinical efficacy of endoscopic surgery of primary sinonasal malignant neoplasms and find out the potential postoperative prognostic factors.
METHOD: Forty-three clinical cases of primary sinonasal malignant neoplasms treated under endoscopy were analyzed retrospectively.
RESULT: Fifteen patients died. The 1-year, 2-year, 3-year and 5-year survival rates were 83. 7% (36/43), 74. 4% (32/43), 69. 8% (30/43) and 65. 1% (28/43), respectively. Kaplan-Meier single-variable analysis showed that gender, T grade, TNM stage and pathological types of olfactory neuroblastoma were statistically significant prognostic factors (P< 0. 05). COX Pro-Portional hazard models showed that TNM stage was an independent prognostic factors.
CONCLUSION: Endoscopic surgery for primary sinonasal malignant neoplasms is a safe and effective minimally invasive surgical treatment, and it is an important supplement to the traditional surgery. Gender, T grade, TNM stage and pathological types of olfactory neuroblastoma might be significant prognostic factors.

PMID: 26514003 [PubMed - in process]

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[Study on the correlation between chronic sinusitis with nasal septum deviation].

[Study on the correlation between chronic sinusitis with nasal septum deviation].

Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2015 Jun;29(12):1103-4

Authors: Ji X, Fu H, Song A

Abstract
OBJECTIVE: Study on the correlation between chronic sinusitis with nasal septum deviation.
METHOD: Randomly selected 722 patients with coronal sinuses CT, statistics the number of cases of nasal septum deviation, cases of nasal septum deviation with chronic sinusitis, the wide and narrow side cases of nasal septum deviation complicated with sinusitis. The number of sinusitis without deviation, and paired test.
RESULT: The incidence of sinusitis between deviation of nasal septum and non deviation were 54. 13% and 44. 66%, the difference between two groups was statistically significant (P<. 05), the incidence of sinusitis with nasal septum deviation of wide and narrow side were 31. 65% and 32. 12%, no significant difference between the two groups (P>0. 01). The incidence of sinusitis high deviation and non high deviation were 59. 54% and 46. 97%, the difference between the two groups was statistically significant (P<0. 05). The number of wide side of upper nasal septum deviation with sinusitis was 54, the narrow side was 66, there is no significant difference between the two groups (P>0. 05).
CONCLUSION: The deviation of nasal septum is associated with the formation of chronic sinusitis, the high deviation is more prone to sinusitis, The incidence of sinusitis and nasal septum deviation on both sides was no different.

PMID: 26514002 [PubMed - in process]

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