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Letter to the editor in response to Mawby et al. A UK experience of daycase cochlear implant surgery.
Cochlear Implants Int. 2016 Feb 4;
Authors: Trudel M, Côté M, Philippon D, Bussières R
PMID: 26843387 [PubMed - as supplied by publisher]
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Intraoperative seizure and cerebrospinal fluid leak during adult cochlear implant surgery.
Cochlear Implants Int. 2016 Feb 4;
Authors: Musser AB, Golub JS, Samy RN, Phero JC
Abstract
Objective and Importance To report a rare case of cerebrospinal fluid gusher and subsequent seizure immediately after cochlear implant electrode insertion. Clinical Presentation After the cochlear implant electrode was inserted, brisk flow of 10 mL of cerebrospinal fluid was seen. The electrode was promptly inserted and the leak was additionally sealed with fascia. Seconds later, the patient had a tonic-clonic seizure lasting 30 seconds. Two additional episodes occurred during the case. Her postoperative course was uneventful with no subsequent seizures. The device has been successfully activated. Intervention & Technique Postoperative imaging showed correct intracochlear placement of the electrode as well as an incidental enlarged vestibular aqueduct. Neurology consultation including electroencephalogram was unremarkable. Conclusion To our knowledge, this is the first report of a seizure temporally associated with cochlear implant electrode insertion. The significance and possible casual relationship between these two events is discussed.
PMID: 26843205 [PubMed - as supplied by publisher]
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Prior exposure to a reverberant listening environment improves speech intelligibility in adult cochlear implant listeners.
Cochlear Implants Int. 2016 Feb 4;
Authors: Srinivasan NK, Tobey EA, Loizou PC
Abstract
Objectives The goal of this study is to investigate whether prior exposure to reverberant listening environment improves speech intelligibility of adult cochlear implant (CI) users. Methods Six adult CI users participated in this study. Speech intelligibility was measured in five different simulated reverberant listening environments with two different speech corpuses. Within each listening environment, prior exposure was varied by either having the same environment across all trials (blocked presentation) or having different environment from trial to trial (unblocked). Results Speech intelligibility decreased as reverberation time increased. Although substantial individual variability was observed, all CI listeners showed an increase in the blocked presentation condition as compared to the unblocked presentation condition for both speech corpuses. Conclusion Prior listening exposure to a reverberant listening environment improves speech intelligibility in adult CI listeners. Further research is required to understand the underlying mechanism of adaptation to listening environment.
PMID: 26843090 [PubMed - as supplied by publisher]
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The Sound Access Parent Outcomes Instrument (SAPOI): Construction of a new instrument for children with severe multiple disabilities who use cochlear implants or hearing aids.
Cochlear Implants Int. 2016 Feb 4;
Authors: Hayward DV, Ritter K, Mousavi A, Vatanapour S
Abstract
Objective To report on the Phase 2 development of the Sound Access Parent Outcomes Instrument (SAPOI), a new instrument focused on formalizing outcomes that parents of children with severe multiple disabilities (SMD) who use amplification prioritize as important. Methods Phase 2 of this project involved item selection and refinement of the SAPOI based on (a) Phase 1 study participant input, (b) clinical specialist feedback, and (c) test-retest instrument reliability. Phase 1 participant responses were utilized to construct a draft version of the SAPOI. Next, clinical specialists examined the instrument for content validity and utility and instrument reliability was examined through a test-retest process with parents of children with SMD. Results The draft SAPOI was constructed based on Phase 1 participant input. Clinical specialists supported content validity and utility of the instrument and the inclusion of 19 additional items across four categories, namely Child Affect, Child Interaction, Parent Well-being, and Child's Device Use. The SAPOI was completed twice at one-month intervals by parents of children with SMD to examine instrument reliability across the four categories (Child Affect, Child Interaction, Parent Well-being, and Child's Device Use). Instrument reliability was strong-to-excellent across all four sections. Discussion The SAPOI shows promise as a much-needed addition to the assessment battery currently used for children with SMD who use cochlear implants and hearing aids. It provides valuable information regarding outcomes resulting from access to sound in this population that currently used assessments do not identify.
PMID: 26841928 [PubMed - as supplied by publisher]
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Speech perception scores in cochlear implant recipients: An analysis of ceiling effects in the CUNY sentence test (Quiet) in post-lingually deafened cochlear implant recipients.
Cochlear Implants Int. 2016 Feb 4;
Authors: Ebrahimi-Madiseh A, Eikelboom RH, Jayakody DM, Atlas MD
Abstract
Objectives To evaluate the clinical utility of the City University of New York sentence test in a cohort of post-lingually deafened cochlear implants recipients over time. Methods 117 post-lingually deafened, Australian English-speaking CI recipients aged between 23 and 98 years (M = 66 years; SD = 15.09) were recruited. CUNY sentence test scores in quiet were collated and analysed at two cut-offs, 95% and 100%, as ceiling scores. Results CUNY sentence scores ranged from 4% to 100% (M = 86.75; SD = 20.65), with 38.8% of participants scoring 95% and 16.5% of participants reaching the 100% scores. The percentage of participants reaching the 95% and 100% ceiling scores increased over time (6 and 12 months post-implantation). The distribution of all post-operative CUNY test scores skewed to the right with 82% of test scores reaching above 90%. Discussion This study demonstrates that the CUNY test cannot be used as a valid tool to measure the speech perception skills of post-lingually deafened CI recipients over time. This may be overcome by using adaptive test protocols or linguistically, cognitively or contextually demanding test materials. Conclusion The high percentage of CI recipients achieving ceiling scores for the CUNY sentence test in quiet at 3 months post-implantation, questions the validity of using CUNY in CI assessment test battery and limits its application for use in longitudinal studies evaluating CI outcomes. Further studies are required to examine different methods to overcome this problem.
PMID: 26841858 [PubMed - as supplied by publisher]
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Experiences from Auditory Brainstem Implantation (ABIs) in four paediatric patients.
Cochlear Implants Int. 2016 Feb 4;
Authors: Lundin K, Stillesjö F, Nyberg G, Rask-Andersen H
Abstract
Introduction Indications for auditory brainstem implants (ABIs) have been widened from patients with neurofibromatosis type 2 (NF2) to paediatric patients with congenital cochlear malformations, cochlear nerve hypoplasia/aplasia, or cochlear ossification after meningitis. We present four ABI surgeries performed in children at Uppsala University Hospital in Sweden since 2009. Methods Three children were implanted with implants from Cochlear Ltd. (Lane Cove, Australia) and one child with an implant from MedEl GMBH (Innsbruck, Austria). A boy with Goldenhar syndrome was implanted with a Cochlear Nucleus ABI24M at age 2 years (patient 1). Another boy with CHARGE syndrome was implanted with a Cochlear Nucleus ABI541 at age 2.5 years (patient 2). Another boy with post-ossification meningitis was implanted with a Cochlear Nucleus ABI24M at age 4 years (patient 3). A girl with cochlear aplasia was implanted with a MedEl Synchrony ABI at age 3 years (patient 4). In patients 1, 2, and 3, the trans-labyrinthine approach was used, and in patient 4 the retro-sigmoid approach was used. Results Three of the four children benefited from their ABIs and use it full time. Two of the full time users had categories of auditory performance (CAP) score of 4 at their last follow up visit (6 and 2.5 years postoperative) which means they can discriminate consistently any combination of two of Ling's sounds. One child has not been fully evaluated yet, but is a full time user and had CAP 2 (responds to speech sounds) after 3 months of ABI use. No severe side or unpleasant stimulation effects have been observed so far. There was one case of immediate electrode migration and one case of implant device failure after 6.5 years. Conclusion ABI should be considered as an option in the rehabilitation of children with similar diagnoses.
PMID: 26841821 [PubMed - as supplied by publisher]
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Effects of Age, Sex and Syllable Number on Voice Onset Time: Evidence from Children's Voiceless Aspirated Stops.
Lang Speech. 2015 Jun;58(Pt 2):152-67
Authors: Yu VY, De Nil LF, Pang EW
Abstract
Voice onset time (VOT) is a temporal acoustic parameter that reflects motor speech coordination skills. This study investigated the patterns of age and sex differences across development of voice onset time in a group of 70 English-speaking children, ranging in age from 4.1 to 18.4 years, and 12 young adults. The effect of the number of syllables on VOT patterns was also examined. Speech samples were elicited by producing syllables /pa/ and /pataka/. Results supported previous findings showing that younger children produce longer VOT values with higher levels of variability. Markedly higher VOT values and increased variability were found for boys at ages between 8 and 11 years, confirming sex differences in VOT patterns and patterns of variability. In addition, all participants consistently produced shorter VOT with higher variability for multisyllables than monosyllables, indicating an effect of syllable number. Possible explanations for these findings and clinical implications are discussed.
PMID: 26677640 [PubMed - indexed for MEDLINE]
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Task type affects location of language-positive cortical regions by repetitive navigated transcranial magnetic stimulation mapping.
PLoS One. 2015;10(4):e0125298
Authors: Hauck T, Tanigawa N, Probst M, Wohlschlaeger A, Ille S, Sollmann N, Maurer S, Zimmer C, Ringel F, Meyer B, Krieg SM
Abstract
OBJECTIVES: Recent repetitive TMS (rTMS) mapping protocols for language mapping revealed deficits of this method, mainly in posterior brain regions. Therefore this study analyzed the impact of different language tasks on the localization of language-positive brain regions and compared their effectiveness, especially with regard to posterior brain regions.
METHODS: Nineteen healthy, right-handed subjects performed object naming, pseudoword reading, verb generation, and action naming during rTMS language mapping of the left hemisphere. Synchronically, 5 Hz/10 pulses were applied with a 0 ms delay.
RESULTS: The object naming task evoked the highest error rate (14%), followed by verb generation (13%) and action naming (11%). The latter revealed more errors in posterior than in anterior areas. Pseudoword reading barely generated errors, except for phonological paraphasias.
CONCLUSIONS: In general, among the evaluated language tasks, object naming is the most discriminative task to detect language-positive regions via rTMS. However, other tasks might be used for more specific questions.
PMID: 25928744 [PubMed - indexed for MEDLINE]
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Cervical vestibular-evoked myogenic potential in vestibular schwannoma after gamma-knife surgery.
Auris Nasus Larynx. 2015 Aug;42(4):265-70
Authors: Lee YF, Lee CC, Wang MC, Liu KD, Wu HM, Guo WY, Shiao AS, Pan DH, Chung WY, Hsu SP
Abstract
OBJECTIVE: Gamma-knife radiosurgery (GKS) for vestibular schwannomas (VSs) has become popular during the last two decades, and a promising tumor control rate has been reported. Therefore, the evaluation and preservation of auditory-vestibular nerve function after GKS have become more and more important in these patients with long-term survival. We have traditionally used pure-tone audiometry (PTA) for evaluation of auditory nerve function, and the caloric test for superior vestibular nerve function. Vestibular-evoked myogenic potential (VEMP) has recently emerged from various neurophysiological examinations for assessment of the integrity of the inferior vestibular nerve function. This novel tool has been established to represent a sacculo-collic reflex. By using these three tools, the auditory-vestibular nerve function of VS patients can be evaluated and monitored before and after GKS.
METHODS: Fourteen patients with unilateral VS that underwent GKS were prospectively recruited. All of them received a battery of auditory-vestibular function tests including PTA, caloric, and cVEMP tests before and after GKS at each time point (1, 6, and 12 months). Our data also included the tumor volumes and their relationship with the PTA, caloric, and cVEMP test results.
RESULTS: The PTA, caloric, and cVEMP tests showed abnormal results before GKS in 85.7%, 78.6% and 78.6% of our VS patients, respectively. The PTA, caloric, and cVEMP results did not show strong correlations between each other. However, there was a tendency that when the tumor grew larger, the auditory-vestibular function deficits became more severe. The PTA and cVEMP test results remained stable during the 1-year follow-up after GKS. However, the caloric test showed transient deterioration at the 6th month follow-up, which then recovered by the 1-year follow-up.
CONCLUSION: The combination of these three tests can help us diagnose VS and assess the change in auditory-vestibular nerve function during the post-GKS follow-up period. The results of these three tests were independent for smaller tumors, but all tests may show abnormal findings with larger tumors. Although the study is still ongoing, the preliminary data showed that GKS treatment would not affect the auditory-vestibular nerve function within a 1-year follow-up period.
PMID: 25666552 [PubMed - indexed for MEDLINE]
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Assessment of nasal mucociliary activity in patients with Behçet's disease.
J Laryngol Otol. 2016 Feb 4;:1-4
Authors: Ozbay I, Kucur C, Temİzturk F, Ozkan Y, Kahraman C, Oghan F
Abstract
OBJECTIVE: To investigate nasal mucociliary clearance in patients with Behçet's disease.
METHODS: Thirty patients with Behçet's disease, diagnosed on the basis of criteria defined by the International Study Group for Behçet's Disease, and 30 healthy individuals were recruited. In both groups, individuals with conditions that could affect nasal mucociliary clearance were excluded. Nasal mucociliary clearance time was evaluated using saccharin tests. The time between placement of a saccharin tablet and the tasting of the saccharin was measured and recorded as the saccharin clearance time.
RESULTS: The mean nasal mucociliary clearance time was significantly longer in the Behçet's disease patients than in the control subjects (p < 0.001). Furthermore, there was a positive correlation between Behçet's disease duration and nasal mucociliary clearance time (p < 0.001, r = 0.882).
CONCLUSION: The results suggest that nasal mucociliary clearance time is longer in Behçet's disease patients than in control subjects, and is positively correlated with disease duration.
PMID: 26841706 [PubMed - as supplied by publisher]
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Early Commencement of Oral Intake and Physical Function are Associated with Early Hospital Discharge with Oral Intake in Hospitalized Elderly Individuals with Pneumonia.
J Am Geriatr Soc. 2015 Oct;63(10):2183-5
Authors: Koyama T, Maeda K, Anzai H, Koganei Y, Shamoto H, Wakabayashi H
PMID: 26480980 [PubMed - indexed for MEDLINE]
High-frequency ultrasound-guided injection for the generation of a novel orthotopic mouse model of human thyroid carcinoma.
Thyroid. 2016 Feb 4;
Authors: Greco A, Albanese S, Auletta L, Mirabelli P, Zannetti A, D'alterio C, Di Maro G, Orlandella FM, Salvatore G, Soricelli A, Salvatore M
Abstract
BACKGROUND: Thyroid carcinoma is the most common endocrine malignancy and has an increasing incidence. High frequency ultrasound (HFUS) has a spatial resolution of 30 µm, which is a property that has been exploited for thyroid visualization and analysis in mice. The aim of this study was to generate a novel orthotopic mouse model of human follicular thyroid carcinoma (FTC) using an HFUS-guided injection system.
METHODS: Twenty Balb/C nude mice were injected in the right lobe of the thyroid with 2 x 106 FTC-133 cells using the microinjection HFUS-guided system, and 20 mice, used as a control, underwent surgical orthotopic implantation of 2 x 106 FTC-133 cells in the right lobe of the thyroid. All mice underwent HFUS imaging 2 weeks after cell injection; HFUS examinations and tumor volume (TV) measurements were repeated weekly. Micro-CT was performed at different time points to determine whether lung metastasis had occurred. TVs were compared between the two models (surgical versus HFUS-guided) using the Mann-Whitney U test, and the Mantel-Cox log-rank test was applied to evaluate the death hazard. Hematoxylin and eosin (H&E) analysis of formalin-fixed, paraffin-embedded mouse tissue was performed to validate the <i>in vivo</i> imaging results.
RESULTS: Nine of eighteen HFUS-guided injected mice survived up to 40 days after the injection of tumor cells. Mice injected surgically had 100% mortality at day 29. Of 38 mice, 29 (14/18 HFUS, 15/20 surgical) showed metastasis in the salivary glands and lymph nodes, and 13 (10/18 HFUS, 3/20 surgical) also showed metastasis in the lungs, which was confirmed by histological analysis. In the surgical group, there was an evident, frequent (12/20 mice) involvement of the contralateral lobe of the thyroid, whereas this feature was only detected in 1 of 18 mice in the HFUS group. The statistical analysis showed the same pattern of growth in the two groups and a significant hazard in the surgical-group mice (P=0.03).
CONCLUSIONS: In our study, we demonstrated the technical feasibility of an HFUS-guided orthotopic mouse model of FTC. The HFUS-guided orthotopic model is easily reproducible and allows prolonged monitoring of the disease because the animals showed an increased survival rate.
PMID: 26844598 [PubMed - as supplied by publisher]
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[Future perspective of immune checkpoint inhibitors in colorectal cancer].
Gan To Kagaku Ryoho. 2015 Nov;42(11):1374-8
Authors: Higuchi H
PMID: 26841457 [PubMed - indexed for MEDLINE]
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[Adjuvant chemo/chemoradiation therapy for colorectal cancer].
Gan To Kagaku Ryoho. 2015 Nov;42(11):1368-73
Authors: Sato T, Nakamura T, Naito M, Ogura N, Yamanashi T, Kosaka Y, Miura H, Tsutsui A, Watanabe M
PMID: 26841456 [PubMed - indexed for MEDLINE]
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[Current status of laparoscopic surgery for colorectal cancer].
Gan To Kagaku Ryoho. 2015 Nov;42(11):1363-7
Authors: Shiomi A
PMID: 26841455 [PubMed - indexed for MEDLINE]
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[Aspirin for the prevention of colorectal cancer].
Gan To Kagaku Ryoho. 2015 Nov;42(11):1357-62
Authors: Nakamura Masato
PMID: 26841454 [PubMed - indexed for MEDLINE]
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[Lower G.I./colon and rectum cancer].
Gan To Kagaku Ryoho. 2015 Nov;42(11):1355-6
Authors: Terashima M
PMID: 26841453 [PubMed - indexed for MEDLINE]
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[III. Fertility preservation for breast cancer patients--approach at our institution].
Gan To Kagaku Ryoho. 2015 Dec;42(13):2444-6
Authors: Doihara H, Shien T
PMID: 26841452 [PubMed - in process]
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[II. Reproductive issues in women with breast cancer--development of a clinical guide on onco-fertility].
Gan To Kagaku Ryoho. 2015 Dec;42(13):2441-3
Authors: Shimizu C
PMID: 26841451 [PubMed - in process]
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[I. Pregnancy-associated breast cancer].
Gan To Kagaku Ryoho. 2015 Dec;42(13):2435-40
Authors: Dobashi K, Akagawa G, Kikutani M
PMID: 26841450 [PubMed - in process]
