The Clinical and Pathological Characteristics of Malignant Struma Ovarii: An Analysis of 144 Published Patients

xlomafota13 shared this article with you from Inoreader The Clinical and Pathological Characteristics of Malignant Struma Ovarii: An Analysis of 144 Published Patients Via radioactive iodine Front Oncol. 2021 Mar 5;11:645156. doi: 10.3389/fonc.2021.645156. eCollection 2021. ABSTRACT The objective of this study is to summarize the clinical and pathologic characteristics of malignant struma ovarii to facilitate the early diagnosis and treatment of this disease. All 144 patients were females from 27 countries. The mean age of the patients at diagnosis was 42.6 years. Overall, 35.71% of the patients underwent unilateral oophorectomy, 58.57% of the patients underwent bilateral oophorectomy, 5.72% of the patients were not ovariectomized, and 38.57% of the patients received radioactive iodine treatment with an average dose of 158.22 mCI each time. "Impure" types accounted for 70.19% of the cases, while pure types accounted for 29.81% of the cases. Among these cases, papillary thyroid carcinoma accounted for 50.00%, follicular thyroid carcinoma accounted for 26.47%, follicular variant of papillary thyroid carcinoma accounted for 18.63%, papillary and follicular mixed thyroid carcinoma accounted for 2.94%, anaplastic carcinoma accounted for 0.98%, and medullary carcinoma accounted for 0.98%. In total, 21 patients (51.22%) had elevated CA125. More than half of the patients (51.94%) had metastasis outside the ovary. The most common metastatic site was the pelvic cavity. The misdiagnosis rate was 17.27%. Mortality was related to metastasis and the cancer type. Gene mutations were found in the NRAS, KRAS, BRAF, and KIT genes and were similar to those in thyroid carcinoma, but some patients (37.5%) did not exhibit any gene mutations. Regardless of the treatment received, the survival rate is high. Treatment could initially include ovariectomy; however, in cases with metastasis and iodine uptake of the metastatic tumor, thyroidectomy, radioactive iodine therapy, and thyroid hormone inhibiting therapy are indicated. PMID:33763376 | PMC:PMC7982850 | DOI:10.3389/fonc.2021.645156 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

The PCOC Symptom Assessment Scale (SAS): A valid measure for daily use at point of care and in palliative care programs

xlomafota13 shared this article with you from Inoreader The PCOC Symptom Assessment Scale (SAS): A valid measure for daily use at point of care and in palliative care programs Via Head and neck cancers by Barbara A. Daveson, Samuel Frederic Allingham, Sabina Clapham, Claire E. Johnson, David C. Currow, Patsy Yates, Kathy Eagar Background Very few measures are used successfully as part of routine care within national palliative care outcome programs. Only a handful of studies examine these measures. The aim of this study is to evaluate the validity of a measure used in a national outcomes program: the Palliative Care Outcomes Collaboration Symptom Assessment Scale (PCOC SAS). Methods A retrospective multi-site cohort study with secondary analysis of routinely collected patient-level data to assess PCOC SAS's internal consistency, construct validity, reliability, interpretability, acceptability and sensitivity. The analyses used two sets, with data collected by inpatient and community palliative care services registered with the Australian national PCOC. Results Dataset one included 1,117 patients receiving palliative care from 21 services. Dataset two included 5,294 patients receiving palliative care from 119 PCOC services. PCOC SAS demonstrated the ability to detect and discriminate dist ress by palliative care phase, functional status and diagnosis. Excellent and good convergent and discriminant validity were demonstrated. Fair through to substantial inter-rater and intra-rater reliability levels were evidenced. Sufficient interpretability resulted along with necessary levels of acceptability and sensitivity. Conclusion PCOC SAS is a valid and reliable patient-reported outcome measure suitable for use in routine clinical care with patients requiring palliative and or end-of-life care, including in national outcomes programs. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Systematic evaluation of laryngeal impairment in Sjögren's syndrome

xlomafota13 shared this article with you from Inoreader Systematic evaluation of laryngeal impairment in Sjögren's syndrome Via http://link.springer.com/journal/405,European archives of oto-rhino-laryngology,The European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino Eur Arch Otorhinolaryngol. 2021 Mar 25. doi: 10.1007/s00405-021-06746-0. Online ahead of print. ABSTRACT INTRODUCTION: Sjögren's syndrome (SjS) causes malfunction of the salivary and lacrimal glands. Consequently, patients suffer from xerostomia and keratoconjunctivitis sicca. This can further affect the voice and swallowing function resulting in an impaired quality of life. Aim of this study is the systematic evaluation of the impact on voice and swallowing-related quality of life in patients with SjS. MATERIAL AND METHODS: SjS patients were classified according to the American-European Consensus Group (AECG) criteria; antibodies to Ro (SS-A) or La (SS-B) antigens were detected, ESSPRI was completed. We used the following quality of life questionnaires: EORTC QLQ H&N 35, Anderson Dysphagia Inventory (ADI) and Voice Handicap Index (VHI). Patients additionally received a detailed phoniatric examination (auditory perception, v ideostroboscopy, acoustic analysis, Dysphonia Severity Index (DSI), aerodynamics measurements). RESULTS: Almost all the 54 patients (96.3%) had a limited quality of life due to their swallowing problems and 48% due to their voice problems. Both values correlated significantly with the degree of xerostomia. In the phoniatric examination, 77.8% had an increased DSI and two-thirds had abnormalities in videostroboscopy. CONCLUSIONS: A reasonable impairment of quality of life in patients with SjS due to the limitations in voice and swallowing function was observed. As SjS does not limitate life expectancy, preservation of quality of life is important. Detection of voice and swallowing problems as potential reasons for quality of life impairment should be detected and, if diagnosed, treated accordingly. PMID:33765165 | DOI:10.1007/s00405-021-06746-0 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A New Montgomery® Salivary Bypass Tube Placement Technique: Report of Procedures Performed on Patients With Tracheoesophageal Fistula or Pharyngoesophageal Stenosis

xlomafota13 shared this article with you from Inoreader A New Montgomery® Salivary Bypass Tube Placement Technique: Report of Procedures Performed on Patients With Tracheoesophageal Fistula or Pharyngoesophageal Stenosis Via ear nose throat Ear Nose Throat J. 2021 Mar 25:1455613211006002. doi: 10.1177/01455613211006002. Online ahead of print. ABSTRACT Salivary Bypass Tube is an important tool to prevent or treat some complications of laryngeal and hypopharyngeal surgery and its placement may prove difficult. In this article, we propose a new technique to simplify its management by using an Oral/Nasal Tracheal Tube Cuffed-Reinforced that allowed us to reduce operating times, complications related to prolonged ge neral anesthesia, and the traumas on the tissues incurred during the forced positioning of the device with standard techniques. PMID:33764199 | DOI:10.1177/01455613211006002 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Montgomery T-Tube Insertion Under ECMO in a Patient With Complete Subglottic Stenosis and Severe Lower Tracheal Collapse

xlomafota13 shared this article with you from Inoreader Montgomery T-Tube Insertion Under ECMO in a Patient With Complete Subglottic Stenosis and Severe Lower Tracheal Collapse Via ear nose throat Ear Nose Throat J. 2021 Mar 25:1455613211006010. doi: 10.1177/01455613211006010. Online ahead of print. ABSTRACT The treatment of complete subglottic stenosis (SGS) remains a challenge due to anatomic and technological limitations. Placement of the Montgomery T-tube is an effective treatment option. For complete SGS patient combined with lower trachea collapse, the ventilation management during the T-tube insertion process is more complicated. Here, we report a case with comp lete SGS combined with severe lower trachea collapse, which was successfully managed with T-tube insertion under extracorporeal membrane oxygenation. PMID:33764200 | DOI:10.1177/01455613211006010 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

A Case of Cochlear Implant Replacement Requiring Full-Thickness Skin Grafting

xlomafota13 shared this article with you from Inoreader A Case of Cochlear Implant Replacement Requiring Full-Thickness Skin Grafting Via ear nose throat Ear Nose Throat J. 2021 Mar 23:145561321996837. doi: 10.1177/0145561321996837. Online ahead of print. ABSTRACT Cochlear implants improve the quality of life of patients with bilateral severe sensorineural hearing loss. Normally, patients with cochlear implants can continue to use the devices for years without any complications. However, equipment failure or infection at the implant site could develop in some patients, and this might often necessitate implant replacement. Alt hough cochlear implant replacement surgery itself is not a major risk in most cases, extensive tissue resection will be required in cases involving infection, and the insertion site of the temporal bone implant will need to be changed. We encountered a case of skin necrosis at the temporal bone implant site caused by constant external irritation from the temple of an eyeglass frame. The patient underwent cochlear implant replacement surgery involving full-thickness skin grafting from the abdomen. Thereafter, the patient's condition improved. Full-thickness skin grafting can be useful in cases of extensive skin defects encountered during cochlear implant replacement. PMID:33752464 | DOI:10.1177/0145561321996837 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Anxio-depressive symptoms in Moroccan women with gynecological cancer: Relief factors

xlomafota13 shared this article with you from Inoreader Anxio-depressive symptoms in Moroccan women with gynecological cancer: Relief factors Via Association française pour l'étude du cancer Bull Cancer. 2021 Mar 19:S0007-4551(21)00071-0. doi: 10.1016/j.bulcan.2020.12.011. Online ahead of print. ABSTRACT INTRODUCTION: Psychosocial determinants can affect the mental health of women who have been diagnosed with gynecological cancer. The aim of this study was to examine how social support and self-esteem are associated with anxiety and depression symptoms in women with gynecological cancer, and who are treated by radical surgery. METHODS: A cross-sectional study was performed, within the oncology department of Ibn Rochd University Hospital, Casablanca, on 100 Moroccan women. They all had undergone radical surgery for gynecological cancer, hysterectomy and/or oophorectomy. RESULTS: Our results showed that patients with gynecological cancer treated by radical surgery exhibited high prevalence rates of anxiety (66%) and depression symptoms (59%). Associations showed that age, having children, medical coverage system, area of residence, working status and socioeconomic status were significantly related to the prevalence of anxiety and depression symptoms (P<0.05). The general social support, family support and significant other support besides high self-esteem reduce significantly the risk of getting anxiety and depression symptoms (P-values<0.05). DISCUSSION: Among patients with gynecological cancer treated by radical surgery, high prevalence of anxiety and depression symptoms was found. Social support and high self-esteem could help improve mental health issues related to this type of cancer. PMID:33752868 | DOI:10.1016/j.bulcan.2020.12.011 View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Melatonin Exerts Anti-Inflammatory, Antioxidant, and Neuromodulatory Effects That Could Potentially Be Useful in the Treatment of Vertigo

xlomafota13 shared this article with you from Inoreader Melatonin Exerts Anti-Inflammatory, Antioxidant, and Neuromodulatory Effects That Could Potentially Be Useful in the Treatment of Vertigo Via International Journal of Otolaryngology The acute phase of vertigo involves multiple neurotransmitters, inflammatory mediators, and products of oxidative stress. The vestibular pathway has multiple melatonin receptors distributed along its path, both centrally and peripherally. In addition, melatonin has been shown to be a powerful antioxidant and anti-inflammatory agent against factors related to vertigo, such as Bax/caspases, interleukins, and chemokines. Likewise, it exerts central GABAergic, antidopaminergic, and anti-migraine functions and regulates sympathetic activity in a similar way to the drugs classically used in acute vestibular crisis. In this review, the role of melatonin as a potential treatment of the acute phase of vertigo is discussed. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

USPSTF Recommendation for Hearing-Loss Screening Among Older Adults

xlomafota13 shared this article with you from Inoreader USPSTF Recommendation for Hearing-Loss Screening Among Older Adults Via JAMA Otolaryngology–Head & Neck Surgery Online First The United States Preventive Services Task Force (USPSTF) recently revisited and reviewed the evidence on assessing the balance of benefit and harm for screening older adults for hearing loss and reaffirmed the conclusion from its last review in 2012 that there is "insufficient evidence" to make a recommendation (I statement). The USPSTF report is based on an updated evidence report and systematic review performed by Feltner and colleagues. The group conducted a rigorous review of major databases and found that relatively few studies had reported on the benefits of hearing care intervention and those that had were not generalizable to the general population because they were mostly performed in veteran populations with no subpopulation analyses. Moreover, no studies assessed for evidence of the presence of unintended harms and consequences of hearing screening and intervention. Lastly, the review did conclude that multiple screening methods can accurately detect hearing loss in older adults. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Does Submandibular Gland Sacrificing Neck Dissection Decrease Salivary Output and Quality of Life?

xlomafota13 shared this article with you from Inoreader Does Submandibular Gland Sacrificing Neck Dissection Decrease Salivary Output and Quality of Life? Via O.R.L. Journal for oto-rhino-laryngology and its borderlands Purpose: Our study aimed to quantify the impact of submandibular gland (SMG) resection during Level I neck dissection (ND) on stimulated salivary output (SSO) and xerostomia-related quality of life in patients with head and neck cancer (HNC). Methods: A retrospective cohort was formed from 32 patients that underwent unilateral or bilateral Level I ND and a control group of 23 patients that had level II–IV ND. SSO (Saxon test) and University of Washington Quality of Life survey results for both groups were compared. Results: Mean SSO was 3.41 g in the SMG resection group and 3.86 g in the control group, with no significant statistical difference. There was no difference in mean SSO between patients with 2 SMGs, a single remaining SMG, or no glands. The mean SSO of SMG resection cases with a history of adjuvant RT was 2.61 g which was below the xerostomia threshold for the Saxon test (2.75 g) and control group patients with RT had a significantly higher mean SSO (4.07 g). The lowest UW-QoL saliva domain score average (53.8) was in the SMG-resected, RT-positive group. Conclusion: Results indicate unilateral or bilateral resection of SMG does not reduce SSO to a significant extent. Adjuvant radiotherapy and SMG resection are additive risk factors for xerostomia and the related loss in quality of life. SMG sparing may be necessary in HNC patients with higher risk for the need of adjuvant radiation. ORL View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.

Symptoms of Depression in Patients with Chemosensory Disorders

xlomafota13 shared this article with you from Inoreader Symptoms of Depression in Patients with Chemosensory Disorders Via O.R.L. Journal for oto-rhino-laryngology and its borderlands Introduction: Patients with chemosensory dysfunction frequently report symptoms of depression. The current study aims to clarify whether the type (smell dysfunction, taste dysfunction, and mixed smell and taste dysfunction), severity, duration, or cause of dysfunction have differential impacts on the symptoms of depression. Methods: 899 patients with chemosensory disorders and 62 controls were included. Following a structured interview and an otorhinolaryngological examination, subjects underwent olfactory tests (Sniffin' Sticks), gustatory tests (taste sprays) and an assessment of depressive symptoms (Beck Depression Inventory). Information on the cause and duration of disorders was also collected. Results: Patients with combined olfactory/gustatory dysfunction had higher depression scores than patients with smell dysfunction only and controls, and no significant difference was found between the smell dysfunction and controls. Anosmi a patients, but not hyposmia patients, exhibited higher depression scores than controls. Among various causes of chemosensory disorders, patients from the posttraumatic group had higher depression scores than patients with other causes of chemosensory dysfunction (sinonasal, idiopathic, or postinfectious). Multiple linear regression analyses suggested that reduced olfactory function was associated with enhanced depression scores in the olfactory disorders group (B = −0.326, t = −2.294, and p = 0.02) and in all patients with chemosensory disorders (B = −0.374, t = −2.550, p = 0.017). Discussion/Conclusion: Simultaneously decreased input of olfaction and gustation seems to have an additive effect on the exacerbation of emotional dysfunction. Early intervention should be considered for depression symptoms in patients with mixed olfactory/gustatory dysfunction in clinical practice. ORL View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.