Ototoxicity from organic solvents assessed by an inner ear test battery.

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Ototoxicity from organic solvents assessed by an inner ear test battery.

J Vestib Res. 2015 Oct 15;25(3,4):177-183

Authors: Hsu PC, Cheng PW, Young YH

Abstract
OBJECTIVE: This study adopted an inner ear test battery comprising audiometry, and ocular vestibular-evoked myogenic potential (oVEMP), cervical VEMP (cVEMP) and caloric tests to assess inner ear function in patients with long term exposure to organic solvents.
METHODS: Eighteen patients exposed to organic solvents and another 18 non-exposed controls from the same environment were enrolled in this study. Each subject underwent an inner ear test battery.
RESULTS: The percentages of abnormalities identified by the oVEMP test, cVEMP test, audiometry and caloric test for the exposed group were 85%, 54%, 50% and 33%, respectively, which showed significant differences when compared with the respective 8%, 8%, 6% and 0 for the non-exposed group. Additionally, a significantly declining trend of inner ear deficits from the utricle to the saccule, cochlea, and semicircular canals was noted in the exposed group, but not in the non-exposed group.
CONCLUSION: Ototoxicity was identified in those exposed to organic solvents, with the sequence of abnormal inner ear function from the utricle to the saccule, cochlea, and semicircular canals.

PMID: 26756133 [PubMed - as supplied by publisher]

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