Feasibility of real-time near-infrared indocyanine green fluorescence endoscopy for the evaluation of mucosal head and neck lesions.

Feasibility of real-time near-infrared indocyanine green fluorescence endoscopy for the evaluation of mucosal head and neck lesions.

Head Neck. 2016 Sep 2;

Authors: Schmidt F, Dittberner A, Koscielny S, Petersen I, Guntinas-Lichius O

Abstract
BACKGROUND: The purpose of this study was to explore the feasibility and potential drawbacks of near-infrared (NIR) endoscopy with indocyanine green (ICG) to examine mucosal head and neck lesions.
METHODS: NIR ICG endoscopy was applied to image head and neck cancer epithelium in vivo. The evaluation of the ICG videos was performed off-line independently by 2 evaluators and blinded with respect to final histopathological results from biopsies taken as the gold standard.
RESULTS: Forty percent of the lesions from 55 patients were histologically malignant. ICG positivity showed a sensitivity, specificity, and accuracy to be related to a malignant tumor of 90.5%, 90.9%, and 89.1%, respectively. The kappa index for the interobserver assessment showed a 94.4% agreement for the assessment of the ICG positivity. Side effects of the NIR ICG endoscopy did not arise.
CONCLUSION: NIR ICG endoscopy in patients with mucosal head and neck lesions was feasible and safe. It might help intraoperatively to differentiate benign from malignant lesions. © 2016 The Authors Head & Neck Published by Wiley Periodicals, Inc. Head Neck, 2016.

PMID: 27590351 [PubMed - as supplied by publisher]

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