Progression-free survival and factors associated with postoperative recurrence in 126 patients with atypical intracranial meningioma.

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Progression-free survival and factors associated with postoperative recurrence in 126 patients with atypical intracranial meningioma.

World Neurosurg. 2017 Aug 21;:

Authors: Phonwijit L, Khawprapa C, Sitthinamsuwan B

Abstract
OBJECTIVE: Atypical meningioma has a higher recurrence rate than benign meningioma. The mainstay of treatment is surgery with or without radiation therapy (RT). The objective of this study was to investigate progression-free survival (PFS) and factors associated with postoperative recurrence in patients with atypical meningioma METHODS: Patients diagnosed with atypical menigioma who underwent surgery at Siriraj Hospital during the 2004 to 2014 study period were included. Features potentially associated with PFS and tumor recurrence from clinical records, operative records, and neuroimaging studies were evaluated and analyzed.
RESULTS: One hundred and twenty-six patients with mean age of 55 years were included. Median PFS was 55 months. Five-year and 10-year PFS rate was 72.5% and 32%, respectively. Median follow-up duration was 52 months. In multivariate analysis, tumor location (convexity, parasagittal/falcine, intraventricular, skull base) (p=0.003) and pial invasion (HR: 2.02; p=0.045) were significantly associated with tumor recurrence. Postoperative RT was associated with reduction in tumor recurrence in both univariate (OR: 0.48; p=0.039) and multivariate analysis (HR: 0.42; p=0.005).
CONCLUSIONS: Tumor location and pial invasion were significantly correlated with increased incidence of tumor recurrence, and postoperative RT was found to be significantly associated with decreased tumor progression and recurrence.

PMID: 28838877 [PubMed - as supplied by publisher]

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