Striatonigral Direct Pathway Activation is Sufficient to Induce Repetitive Behaviors

Publication date: Available online 20 September 2017
Source:Neuroscience Research
Author(s): Youcef Bouchekioua, Iku Tsutsui-Kimura, Hiromi Sano, Miwako Koizumi, Kenji F. Tanaka, Keitaro Yoshida, Yutaka Kosaki, Shigeru Watanabe, Masaru Mimura
Pharmacological intervention in the substantia nigra is known to induce repetitive behaviors in rodents, but a direct causal relationship between a particular neural circuit and repetitive behavior has not yet been established. Here we demonstrate that acute excitation in dopamine D1 receptor-expressing MSNs terminals in the substantia nigra pars reticulata by optogenetics resulted in sustained and chronic repetitive behaviors. These data show for the first time that activation of the striatonigral direct pathway is sufficient to generate motor stereotypies.



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