The Role of Chemokines in Thyroid Carcinoma.

The Role of Chemokines in Thyroid Carcinoma.

Thyroid. 2017 Sep 11;:

Authors: Yapa S, Mulla O, Green V, England J, Greenman J

Abstract
Global incidence of thyroid cancer is increasing and metastatic spread to lymph nodes is common in papillary thyroid carcinoma. The metastatic course of thyroid carcinoma is an intricate process involving invasion, angiogenesis, cell trafficking, extravasation, organ specific homing and growth. A key aspect in this process involves a multitude of interactions between chemokines and their receptors. Chemokines are a group of small proteins, which act to elicit normal physiological and immune responses principally through recruitment of specific cell populations to site of infection or malignancy. Thyroid cancer cells, like other tumours, possess the ability to corrupt the chemokine system to their advantage by altering cell movement into the tumour microenvironment and affecting all aspects of thyroid cancer progression.

PMID: 28891394 [PubMed - as supplied by publisher]

from #ENT-PubMed via ola Kala on Inoreader http://ift.tt/2wWjP1p