2. Do repeated limbic seizures induce depression-like behavior in rats?

Publication date: November 2017
Source:Clinical Neurophysiology, Volume 128, Issue 11
Author(s): W. McIntyre Burnham, Brian W. Scott
It has been reported that rapid kindling of the hippocampus produces lasting depression-like behavior in rats, as evidenced by increased immobility in the forced swim test and a loss of preference for sweetened water (Mazarati et al., 2007). This might suggest that repeated limbic seizure activity could be the cause of the depression often seen in patients with temporal lobe epilepsy.Sixty-day old male Wistar rats were implanted with electrodes in the amygdala and ventral hippocampus and kindled (or sham kindled) daily to a criterion of 10 stage 5 seizures. Two weeks later subjects were tested in the forced swim and sweet taste preference tests. No differences were found between the kindled and sham kindled animals.Subsequently, twenty-one day old male Wistar rat pups were implanted and quick kindled (or sham kindled) in the ventral hippocampus. Kindling was accomplished in a single day by stimulating every 5min for 84 stimulations. Four days or two weeks later they were tested in the forced swim and sweet taste preference tests. No differences were found between the kindled and sham kindled animals.The present data do not support the idea that repeated limbic seizures induce depression-like behavior in rats.



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