Αρχειοθήκη ιστολογίου

Κυριακή 8 Οκτωβρίου 2017

Dramatic response to nivolumab in xeroderma pigmentosum skin tumor

Abstract

We report the case of a 6-year-old female with xeroderma pigmentosum (XP) who developed a nonoperable scalp tumor, treated with anti-programmed cell death protein 1 (anti-PD-1) therapy (nivolumab). She presented with a sarcomatoid carcinoma of the scalp with bone lysis as well as vascular and meningeal contact. Nivolumab was initiated because it has emerged as a promising immunotherapy. We observed a dramatic tumor response with excellent tolerance. However, while on nivolumab therapy she developed two large skin melanomas and several squamous cell carcinomas, which have been resected. These results demonstrate that cancer immunotherapy in patients with XP can be impressive but complex and warrants further investigation.



from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2kydCpA

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