Impact of surgical approach on perioperative and long-term outcomes following esophagectomy for esophageal cancer

Abstract

Background

Surgical resection remains a critical component of esophageal cancer treatment with curative-intent. The aim of this study was to compare open (OE) to minimally invasive Ivor Lewis esophagectomy (MIE) with respect to perioperative and oncologic outcomes.

Methods

Retrospective single-institution review of MIE and OE patients operated between 2001 and 2015 was conducted. Univariable and multivariable models were created using Cox regression. The Kaplan–Meier method was used to compare oncologic outcomes. Propensity score matching was used to compare oncological outcomes in MIE and OE patients.

Results

Of 210 esophageal resection patients, 47% had OE (137/291) and 25% had MIE (73/291). The MIE and OE groups were comparable with respect to patient factors and operative details. Fewer OE patients received neoadjuvant chemoradiation. MIE was associated with improved lymph node yield, (MIE = 30 [IQR:22–39]; OE = 14 [IQR:7–19], p < 0.001), less intraoperative blood loss (MIE = 312 mL [100–400]; OE = 657 mL [350–700], p < 0.001), and shorter median length of stay (MIE = 10 days [IQR = 8–14]; OE = 14 days [IQR = 11–22] p < 0.01). The OE group had significantly more adverse events resulting in reoperation or intensive care unit admission (MIE = 21%; OE = 34%; p < 0.01). On multivariable analysis, age and positive resection margins were associated with decreased odds of survival. The number of lymph nodes retrieved, positive resection margins, and pathologic stage were significant predictors of disease-free survival. Analysis of 69 matched pairs showed equivalent median overall survival (MIE = 49 months [18–67]; OE = 29 months [17–69]; p = 0.26) and disease-free survival (MIE = 9 [6–22]; OE = 13 [6–22]; p = 0.45) between the two groups.

Conclusions

Although long-term oncologic outcomes appear to be similar, MIE is associated with significantly less intraoperative blood loss, improved lymph node yield, less risk of severe postoperative adverse events, and shorter length of stay.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2y278FW