Αρχειοθήκη ιστολογίου

Τετάρτη 4 Οκτωβρίου 2017

Layer- and Subregion-Specific Differences in the Neurophysiological Properties of Rat Medial Prefrontal Cortex Pyramidal Neurons

Medial prefrontal cortex (mPFC) is critical for the expression of long term conditioned fear. However, the neural circuits involving fear memory acquisition and retrieval are still unclear. Two subregions within mPFC that have received a lot of attention are the prelimbic (PL) and infralimbic (IL) cortices (e.g., Santini et al. 2008; Song et al. 2015). Interestingly, PL and IL may play distinct roles during fear memory acquisition and retrieval but the underlying mechanism is poorly understood. One possibility is that the intrinsic membrane properties differ between these subregions. Thus, the current study was carried out to characterize the basic membrane properties of mPFC neurons in different layers and subregions. We found that pyramidal neurons in L2/3 were more hyperpolarized and less excitable than in L5. This was observed in both IL and PL and was associated with an enhanced h-current in L5 neurons. Within L2/3, IL neurons were more excitable than those in PL, which may be due to a lower spike threshold and higher input resistance in IL neurons. Within L5, the intrinsic excitability was comparable between neurons obtained in IL and PL. Thus, the heterogeneity in physiological properties of mPFC neurons may underlie the observed subregion-specific contribution of mPFC in cognitive function and emotional control, such as fear memory expression.



from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2y1ZMB4

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