Propranolol and Oxandrolone Therapy Accelerated Muscle Recovery in Burned Children.

Introduction: Severe burns result in prolonged hypermetabolism and skeletal muscle catabolism. Rehabilitative exercise training (RET) programs improved muscle mass and strength in severely burned children. The combination of RET with [beta]-blockade or testosterone analogues showed improved exercise-induced benefits on body composition and muscle function. However, the effect of RET combined with multiple drug therapy on muscle mass, strength, cardiorespiratory fitness and protein turnover are unknown. In this placebo-controlled randomized trial, we hypothesize that RET combined with oxandrolone and propranolol (Oxprop) will improve muscle mass and function and protein turnover in severely burned children compared to burned children undergoing the same RET with a placebo. Methods: We studied 42 severely burned children (7 - 17 years) with severe burns over 30% of the total body surface area. Patients were randomized to placebo (22 control) or to Oxprop (20) and began drug administration within 96 hours of admission. All patients began RET at hospital discharge as part of their standardized care. Muscle strength (N[middle dot]m), power (W), VO2peak, body composition, and protein fractional synthetic (FSR) and breakdown (FBR) rates were measured pre- (PRE) and post-RET (POST). Results: Muscle strength and power, lean body mass and VO2peak increased with RET in both groups (p

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