Relationship between occlusal features and enzyme replacement therapy in patients with mucopolysaccharidoses

Publication date: Available online 13 October 2017
Source:Journal of Oral and Maxillofacial Surgery
Author(s): Dmitry José de Santana Sarmento, Thiara Karine de Araújo, Germana de Queiroz Tavares Borges Mesquita, Denise Nóbrega Diniz, Fátima Roneiva Alves Fonseca, Paula Frassinetti V. Medeiros, Maria Teresa Botti Rodrigues dos Santos, Gustavo Pina Godoy
PurposeThe aim of this study was describe the relationship between occlusal features and enzyme replacement therapy in patients with mucopolysaccharidoses.Materials and MethodsA cross-sectional study was conducted. The sample consisted of 20 patients with mucopolysaccharidoses, ten of whom were undergoing treatment at a hospital in northeast Brazil. Occlusal features were evaluated by clinical examination and panoramic radiography. A structured questionnaire was administered to evaluate the dental care of the patient. The Pearson's Chi-squared, Fisher's exact and Mann-Whitney tests were used for data analysis, adopting a level of significance of 5%.ResultsMarked overjet (75%) and anterior open bite (70%) were the most frequent occlusal alterations, and 15% had class III disorders. Radiography revealed the presence of impacted teeth (75%) and the prolonged retention of the deciduous teeth (65%). It was observed that patients with enzyme replacement therapy had a lower average maximum protrusion (p=0.033). A total of 75% of mothers said they had not been advised to take their children to the dentist, and 10% of children had never been to the dentist.ConclusionPatients with mucopolysaccharidoses exhibited significant occlusal alterations, especially marked overjet and anterior open bite. Enzyme replacement therapy seems to influence the maximum protrusion of patients.



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