Short sleep and risk of proteinuria in 3-year-olds in Japan: A population-based cohort study

Publication date: Available online 9 October 2017
Source:Sleep Medicine
Author(s): Hongyan Chen, Maki Shinzawa, Hironobu Tokumasu, Shiro Tanaka, Koji Kawakami
ObjectiveTo examine whether short sleep at 18 months of age is associated with risk of proteinuria at 3 years of age.MethodsA population-based cohort study using municipal health check-up data from 62,623 children born between March 1, 2004, and April 30, 2011, and followed to 3 years via questionnaire in Kobe City, Japan. Sleep duration was calculated from wake time and bedtime at the 18-month health check-up by standardized parent-reported questionnaires. Proteinuria, defined as dipstick urinary protein of ≥1+, was measured by dipstick urinalysis at 3 years. Multivariable logistic regression was used to generate adjusted olds ratios.ResultsIn total, 2253 (3.6%) children had short nighttime sleep (≤8 hours) at 18 months. At 3 years, 765 (1.2%) children had proteinuria. The adjusted odds ratio for proteinuria among children with 8 hours of sleep or less versus those with normal sleep of 10 hours per night was 1.50 (95% confidence interval, 1.07-2.11; P =0.02). Odds ratios of the same direction but weaker magnitude were observed for children with bedtime at 22:00 or later, and those with wake time at 6:00 or earlier.ConclusionsShort sleep at 18 months was associated with risk of proteinuria at 3 years. Future research is warranted to examine whether sleep programs targeting early childhood may have additional potential health benefits for kidney development.



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