Targeting CDH17 in cancer: when blocking the ligand beats blocking the receptor?

Cadherin-17 (CDH17) has been implicated as pro-tumorigenic for many years but mechanisms have been unclear. A Spanish team have generated antibodies to an RGD-motif in CDH17 that inhibits integrin α2β1 binding to CDH17 and thereby inhibits integrin activation, tumorigenesis and metastasis. These reagents may have therapeutic potential.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2yfC0CR