Isotemporal Substitution of Sedentary Behavior and Physical Activity on Function.

The amount of time spent in sedentary behaviors (SB) progressively increases with age, while reducing time spent in light (LPA) and moderate-to-vigorous physical activity (MVPA). These trajectories in PA and SB are linked to accelerated reductions in physical functioning. PURPOSE: To examine the association of substituting SB time with LPA and MVPA on physical function in older adults. METHODS: Ninety-one older adults (mean age: 70.7 +/- 10.2 yr) wore a hip-mounted accelerometer to measure SB, LPA, and MVPA time. Measures of physical function included a 400m walk test (400W), usual gait speed (UGS), and 5-time sit-to-stand (5xSTS), and the short physical performance battery (SPPB). Isotemporal substitution regression modeling was performed to assess the relationship of replacing the amount of time spent in one activity for another. RESULTS: Replacing 30 min[BULLET OPERATOR]d-1 of SB with LPA was associated with a significant improvement in 400W (p = 0.0497), while MVPA resulted in a significant improvement (p

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