Schnitzler syndrome with IgG gammopathy and elevated IL-1β and IL-17 in skin biopsy

Schnitzler syndrome is a rare disorder known for chronic urticarial rash, systemic inflammation, and monoclonal gammopathy.1 Historically it has been associated with immunoglobulin M (IgM), but in the past 20 years new cases have been described that include variants with an immunoglobulin G (IgG) gammopathy. We report a case of Schnitzler syndrome associated with IgG gammopathy and increased expression of interleukin (IL)-1β and IL-17 by immunohistochemistry at skin biopsy examination.

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