Αρχειοθήκη ιστολογίου

Πέμπτη 28 Δεκεμβρίου 2017

A phenomenological model of the synapse between the inner hair cell and auditory nerve: Implications of limited neurotransmitter release sites

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Publication date: Available online 28 December 2017
Source:Hearing Research
Author(s): Ian C. Bruce, Yousof Erfani, Muhammad S.A. Zilany
Peterson and Heil [Hear. Res., In Press] have argued that the statistics of spontaneous spiking in auditory nerve fibers (ANFs) can be best explained by a model with a limited number of synaptic vesicle docking (release) sites (∼4) and a relatively-long average redocking time (∼16–17 ms) for each of the sites. In this paper we demonstrate how their model can be: i) generalized to also describe sound-driven ANF responses and ii) incorporated into a well-established and widely-used model of the entire auditory periphery [Zilany et al., J. Acoust. Soc. Am. 135, 283–286, 2014]. The responses of the new model exhibit substantial improvement in several measures of ANF spiking statistics, and predicted physiological forward-masking and rate-level functions from the new model structure are shown to also better match published physiological data.



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