Αρχειοθήκη ιστολογίου

Σάββατο 9 Δεκεμβρίου 2017

Network-based brain stimulation selectively impairs spatial retrieval

elsevier-non-solus.png

Publication date: January–February 2018
Source:Brain Stimulation, Volume 11, Issue 1
Author(s): Kamin Kim, Amber Schedlbauer, Matthew Rollo, Suganya Karunakaran, Arne D. Ekstrom, Nitin Tandon
BackgroundDirect brain stimulation via electrodes implanted for intracranial electroencephalography (iEEG) permits the modulation of endogenous electrical signals with significantly greater spatial and temporal specificity than non-invasive approaches. It also allows for the stimulation of deep brain structures important to memory, such as the hippocampus, that are difficult, if not impossible, to target non-invasively. Direct stimulation studies of these deep memory structures, though, have produced mixed results, with some reporting improvement, some impairment, and others, no consistent changes.Objective/hypothesisWe hypothesize that to modulate cognitive function using brain stimulation, it is essential to modulate connected nodes comprising a network, rather than just alter local activity.MethodsiEEG data collected while patients performed a spatiotemporal memory retrieval task were used to map frequency-specific, coherent oscillatory activity between different brain regions associated with successful memory retrieval. We used these to identify two target nodes that exhibited selectively stronger coupling for spatial vs. temporal retrieval. In a subsequent session, electrical stimulation - theta-bursts with a fixed phase-lag (0° or 180°) – was applied to the two target regions while patients performed spatiotemporal retrieval.ResultsStimulation selectively impaired spatial retrieval while not affecting temporal retrieval, and this selective impairment was associated with theta decoupling of the spatial retrieval network.ConclusionThese findings suggest that stimulating tightly connected nodes in a functional network at the appropriate phase-lag may effectively modulate the network function, and while in this case it impaired memory processes, it sets a foundation for further network-based perturbation studies.



from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2jDlwuW

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου