Bidirectional and context-dependent changes in theta and gamma oscillatory brain activity in noradrenergic cell-specific Hcrtr1 KO mice

Introduction: Noradrenaline (NA) and hypocretins (Hcrt) and their cognate receptors modulate the electrical properties of brain circuits that dynamically sculpt wakefulness and define mnesic traces. Locus coeruleus NA cells (LC-NA) respond to salient environmental changes, and, through widespread NA release, 'reset' networks to mediate behavioral adaptation. Among other inputs, they receive dense projections from hypothalamic Hcrt neurons. The range of behaviors that the Hcrt-to-LC-NA neuronal connection implements, remains incompletely defined.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2ENbEqG