Candidate Gene Analysis in the São Paulo Epidemiologic Sleep Study (EPISONO) Shows an Association of Variant in PDE4D and Sleepiness

Sleepiness and cardiovascular disease share common molecular pathways; thus, genetic risk factors for sleepiness may also predict cardiovascular disease risk. This study explored the associations between subjective sleepiness and single nucleotide polymorphisms (SNPs) in candidate genes within oxidative stress, inflammatory and neuronal pathways, which may contribute to sleepiness and downstream cardiovascular disease risk: Cytochrome B-245, Alpha Polypeptide (CYBA), Cytochrome B-245, Beta Polypeptide (CYBB), Neutrophil Cytosolic Factor (NCF2), Tumor Necrosis Factor-Alpha (TNFA) and Phosphodiesterase 4D (PDE4D).

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2qYs0Ll