RBD: a red flag for cognitive impairment in Parkinson’s disease?

Publication date: Available online 31 January 2018
Source:Sleep Medicine
Author(s): Yiqi Lin, Shengdi Chen
The increasing evidence indicates that there is a strong association between rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease - cognitive impairment (PD-CI). Numerous longitudinal and cross-sectional studies have shown that RBD may be an important risk factor and predictor of Parkinson's disease – mild cognitive impairment (PD-MCI) and Parkinson's disease dementia (PDD), which may be explained by association of mechanisms between RBD and PD-CI including neurotransmitter alterations, genetic mutation, neuroinflammation, alpha-synuclein inclusion, abnormal cerebral metabolism and slowing of cortical activity. Understanding the role of RBD in cognition of PD, we may predict and prevent the presence of PD-CI. The purpose of this comprehensive narrative review was to investigate the role of RBD in cognition of PD patients and its possible mechanism with lights from clinical epidemiological evidence, neuroimaging and electrophysiology studies.



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