The Pathological Spectrum and Clinical Correlation of Pigmented Purpuric Dermatosis– A Retrospective Review of 107 Cases

Abstract

Background

Various pathological findings have been reported in pigmented purpuric dermatosis, but their clinical significance remains unclear.

Methods

We retrospectively reviewed demographics, clinical presentations, pathological patterns, and concurrent systemic diseases among biopsy-confirmed cases of pigmented purpuric dermatosis.

Results

A total of 107 cases were ascertained. Five major pathological patterns were identified: lichenoid (45/107, 42.1%), perivascular (40/107, 37.4%), interface (11/107, 10.3%), spongiotic (7/107, 6.5%), and granulomatous (4/107, 3.7%). Lymphocytic vasculitis was present in 17 patients (15.9%), and Langerhans cell microabscess was seen in 4 (3.7%). Nine patients had partial features mimicking mycosis fungoides but none were confirmed. The lichenoid, perivascular and spongiotic patterns correlated to lichen aureus, Schamberg's and eczematoid clinical variants, respectively. The interface pattern was associated with a higher risk of co-occurring with autoimmune diseases (18.2%, p=0.0280) and gout (27.3%, p=0.0180)

Conclusions

This study described the wide pathological spectrum of pigmented purpuric dermatosis among Asians. Physicians should be aware about the clinical and pathological variations to facilitate diagnosis.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2nv1OTF