Occurrence of Thalamic High Frequency Oscillations in Patients with Different Tremor Syndromes

Abnormal oscillatory activity in the basal ganglia plays a pivotal role in the pathophysiology of movement disorders. In particular, an increase of beta activity (15-30Hz) in the subthalamic nucleus (STN) has been suggested to underlie slowing of movement in Parkinson's disease (PD) (Kühn et al., 2009; Ray et al., 2008). Beta oscillations are modulated by dopaminergic medication (Brown et al., 2001; Levy et al., 2002; Priori et al., 2004) and voluntary movement (Cassidy et al., 2002; Levy et al., 2002).

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