Subventricular zone predicts high velocity of tumor expansion and poor clinical outcome in patients with low grade astrocytoma

Publication date: Available online 25 February 2018
Source:Clinical Neurology and Neurosurgery
Author(s): Bin Wen, Feixian Fu, Liangbo Hu, Qiuyi Cai, Junshi Xie
ObjectiveThe aim of this study is to clarify the association between subventricular zone (SVZ) involvement and velocity of diametric expansion(VDE) in patients with low-grade astrocytoma and also assessed the clinical outcome of those patients.Materials and MethodsA total of 168 adult patients with newly diagnosed supratentorial low-grade astrocytoma were studied retrospectively.ResultsThere were 73 patients had SVZ involvement. Patients with SVZ involvement(7.16±6.53mm/y) had a higher VDE than patients without SVZ involvement(4.38±5.35mm/y). VDE was modeled as a categorical variable(＜4, ≥4 and, ＜8, ≥8 and, ＜12, ≥12 mm/y). Logistic regression showed that SVZ involvement was associated with high VDE after adjusting by confounding variables. On the univariate analysis, the results showed that tumor involved with SVZ, VDE≥4 mm/y, VDE≥8 mm/y, and VDE≥8 mm/y were significant predictors of a shorter OS, progression-free survival (PFS) and malignant progression-free survival (MFS)(all p ＜0.05). The categorical variables of VDE (＜4 mm/y, ≥4 mm/y and, ＜8 mm/y, ≥8mm/y and, ＜12 mm/y, ≥12 mm/y) were adjusted by confounding variables in multivariate analysis, respectively. The results indicated that VDE ≥8 mm/y, VDE≥12 mm/y were worse prognostic factors for OS, while VDE ≥4 mm/y, VDE ≥8 mm/y and VDE≥12 mm/y were related to shorter PFS and MFS. In addition, SVZ involvement was prognostic factors in predicting OS and PFS except MFS.ConclusionOur results demonstrated that SVZ involvement predicted high VDE and worse clinical outcome, and high VDE was associated with poor prognosis in patients with low-grade astrocytoma.



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