The HSF1 transcription factor is an integrator of the cellular stress response and its expression has demonstrated poor prognosis in multiple myeloma. Novel anti-HSF1 small molecule inhibitors CCT251236 and KRIB11 demonstrate in vitro and in vivo anti-myeloma activity, representing a novel approach for targeting the heat shock response in myeloma.
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2simVhv
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