A critical role of IL-18 in transformation and maturation of naïve eosinophils to pathogenic eosinophils

Publication date: Available online 2 March 2018
Source:Journal of Allergy and Clinical Immunology
Author(s): Sathisha Upparahalli Venkateshaiah, Akanksha Mishra, Murli Manohar, Alok K. Verma, Priya Rajavelu, Rituraj Niranjan, Laurianne G. Wild, Nereida A. Parada, Uwe Blecker, Joseph A. Lasky, Anil Mishra.

Teaser

The current studies demonstrate a critical role of IL-18 in transforming IL-5 generated naïve eosinophils into the distinct inflammatory CD101⁺CD274⁺ expressing mature and activated tissue eosinophils that promote disease pathogenesis.


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