Case of Primary Central Nervous System Lymphoma Arising at Site of Remote Herpes Encephalitis

Publication date: May 2018
Source:World Neurosurgery, Volume 113
Author(s): Victor Li, Adrian B. Levine, Peter A. Gooderham, Stephen Yip, Jason Chew
BackgroundPrimary central nervous system lymphoma (PCNSL) is a rare malignancy that usually arises in the context of severe immunosuppression but has incompletely understood etiology, limiting effective treatments.Case DescriptionWe present the case of an 81-year-old immunocompetent man who developed a PCNSL in the right temporal lobe, at the site of a remote episode of herpes simplex virus (HSV) encephalitis 8 years prior. There are numerous viruses with known oncogenic associations; however, to our knowledge, this is the first reported case of PCNSL with an antecedent HSV infection.ConclusionsWe discuss this case in the context of our current understandings of the pathogenesis of HSV encephalitis and PCNSL and postulate mechanisms through which the 2 could be associated.



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