How do we assess what lies beneath in eosinophilic esophagitis?

The working definition for eosinophilic esophagitis (EoE) is a chronic, immune/antigen-mediated disorder characterized histologically by esophageal inflammation with intraepithelial eosinophils and clinically by symptoms of esophageal dysfunction.1 Although this definition has proved valuable for the standardization of the diagnosis and research criteria, it is becoming clear that it only scratches the surface. To say it another way, the findings from analysis of a mucosal biopsy sample reveal only the tip of an iceberg of inflammation and fibrosis that lie beneath in the esophageal wall.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2ubyoQY