Involvement of transient receptor potential vanilloid 2 in intra-oral incisional pain

Abstract

Objective

To examine whether TRPV2 contribute to the changes in intra-oral thermal and mechanical sensitivity following incision of buccal mucosa.

Materials and Methods

Buccal mucosal pain threshold were measured after the incision. Changes in the number of TRPV2-immunoreactive trigeminal ganglion neurons which innervate the whisker pad skin and buccal mucosa, changes in the number of isolectin B4-negative/positive TRPV2-immunoreactive trigeminal ganglion neurons which innervate the whisker pad skin and the buccal mucosa and the effect of peripheral TRPV2 antagonism on the pain threshold of incisional whisker pad skin and buccal mucosa were examined after these injuries.

Results

Buccal mucosal pain hypersensitivities were induced on day 3 following the incision. The total number of TRPV2-immunoreactive trigeminal ganglion neurons and the number of isolectin B4-negative TRPV2-immunoreactive trigeminal ganglion neurons which innervate the whisker pad skin and buccal mucosa were increased. Buccal mucosal TRPV2 antagonism completely suppressed the heat and mechanical hypersensitivities, but not cold hypersensitivity. TRPV2 antagonist administration to the incisional whisker pad skin only partially suppressed pain hypersensitivities.

Conclusion

The increased expression of TRPV2 in peptidergic trigeminal ganglion neurons innervating the incisional buccal mucosa is predominantly involved in buccal mucosal heat hyperalgesia and mechanical allodynia following buccal mucosal incision.

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