Overexpression of PIK3CA in head and neck squamous cell carcinoma is associated with poor outcome and activation of the YAP pathway

We have shown that in HNSCC tumors high expression of PIK3CA is a poor prognosis factor. Increased gene expression leads to augmented level of the p110α protein. This correlates with a decrease in the phosphorylation of the YAP transcription regulator (YAP-P) enabling its translocation to the nucleus and the transcription of YAP-target genes that promote different processes involved in tumorigenesis. The connection between increased PIK3CA expression and YAP nuclear translocation has not been established yet at the molecular level (dotted red arrow).

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader https://ift.tt/2I2BNDF