Αρχειοθήκη ιστολογίου

Τετάρτη 4 Απριλίου 2018

Rectal ulcer and pseudomalignant epithelial changes after prostate seed brachytherapy: A rare complication with a diagnostic pitfall

Publication date: Available online 4 April 2018
Source:Annals of Diagnostic Pathology
Author(s): Hwajeong Lee, Natallia Sheuka, Osama El-kadi, Brian P. Murray, Hugh A. Fisher, Bhaskar V.S. Kallakury, Edward C. Lee, Ann Boguniewicz, Timothy A. Jennings
BackgroundImplant brachytherapy (IBT) is a well-recognized treatment modality for early stage prostate cancer. Rectal ulcer and rectourethral fistula complicating IBT may cause an alteration of the normal anatomic landmarks. In this context, pseudomalignant radiation-induced changes within prostatic epithelium may be misinterpreted as a primary rectal malignancy. Such challenging and misleading findings have not been described, and may not be recognized as such.Materials and methodsWe present the clinical and pathologic aspects of two patients who underwent IBT for low stage prostate cancer that was complicated by deep rectal ulcer. Both patients underwent extensive palliative surgical resection for disease control.ResultsThe histologic changes in both cases were noteworthy for extensive necrosis and inflammation of the prostate, associated with loss of recto-prostatic anatomical landmarks. Prostatic glands showed striking radiation-induced atypia and pseudomalignant epithelial changes extending to the rectal ulcer bed, with no residual viable tumor. The first patient had undergone a biopsy of the rectal ulcer bed that was misinterpreted as a rectal adenocarcinoma prior to surgery. The similarity between atypical glands of the biopsy and the benign prostatic tissue with radiation-induced atypia in resection specimen confirmed their benign nature.ConclusionsDeep rectal ulcer complicating IBT may lead to distortion of the normal recto-prostatic anatomical landmarks, resulting in detection of pseudo-malignant prostatic glands at the ulcer base. Such findings may be mistaken for a primary rectal malignancy in limited biopsy material if not familiar to the pathologist.



from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader https://ift.tt/2GwF2XL

Δεν υπάρχουν σχόλια:

Δημοσίευση σχολίου