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Κυριακή 8 Απριλίου 2018

The relationship between mismatch response and the acoustic change complex in normal hearing infants

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Publication date: June 2018
Source:Clinical Neurophysiology, Volume 129, Issue 6
Author(s): Kristin M. Uhler, Sharon K. Hunter, Elyse Tierney, Phillip M. Gilley
ObjectiveTo examine the utility of the mismatch response (MMR) and acoustic change complex (ACC) for assessing speech discrimination in infants.MethodsContinuous EEG was recorded during sleep from 48 (24 male, 20 female) normally hearing aged 1.77 to –4.57 months in response to two auditory discrimination tasks. ACC was recorded in response to a three-vowel sequence (/i/-/a/-/i/). MMR was recorded in response to a standard vowel, /a/, (probability 85%), and to a deviant vowel, /i/, (probability of 15%). A priori comparisons included: age, sex, and sleep state. These were conducted separately for each of the three bandpass filter settings were compared (1–18, 1–30, and 1–40 Hz).ResultsA priori tests revealed no differences in MMR or ACC for age, sex, or sleep state for any of the three filter settings. ACC and MMR responses were prominently observed in all 44 sleeping infants (data from four infants were excluded). Significant differences observed for ACC were to the onset and offset of stimuli. However, neither group nor individual differences were observed to changes in speech stimuli in the ACC. MMR revealed two prominent peaks occurring at the stimulus onset and at the stimulus offset. Permutation t-tests revealed significant differences between the standard and deviant stimuli for both the onset and offset MMR peaks (p < 0.01). The 1–18 Hz filter setting revealed significant differences for all participants in the MMR paradigm.ConclusionBoth ACC and MMR responses were observed to auditory stimulation suggesting that infants perceive and process speech information even during sleep. Significant differences between the standard and deviant responses were observed in the MMR, but not ACC paradigm. These findings suggest that the MMR is sensitive to detecting auditory/speech discrimination processing.SignificanceThis paper identified that MMR can be used to identify discrimination in normal hearing infants. This suggests that MMR has potential for use in infants with hearing loss to validate hearing aid fittings.



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