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Interferences between Clot in the Erythrocyte Sediment and Hemostasis Exploration.: Interferences between Clot in the Erythrocyte Sediment and Hemostasis Exploration.Clin Lab. 2020 Sep 01;66(9):Authors: Delianu C, Moscalu M, Ghizdovat V, Hurjui LL, Hurjui I, Tărniceriu CC, Foia LAbstract BACKGROUND: The selection and rejection of non-conforming coagulation specimens is essential in safeguarding quality management in hemostasis laboratories that provide routine testing for bleeding and thrombotic...
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Semen Creatine and Creatine Kinase Activity as an Indicator of Sperm Quality.: Semen Creatine and Creatine Kinase Activity as an Indicator of Sperm Quality.Clin Lab. 2020 Sep 01;66(9):Authors: Nasrallah F, Hammami MB, Omar S, Aribia HB, Sanhaji H, Feki MAbstract BACKGROUND: The role of creatine (Cr) and creatine kinase (CK) in sperm function remains unclear. The study aimed to assess Cr and CK in seminal plasma and test their association with sperm characteristics. METHODS: The study...
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Study for the Diagnostic Screening of Paroxysmal Nocturnal Hemoglobinuria in Older Patients with Unexplained Anemia and/or Cytopenia.: Study for the Diagnostic Screening of Paroxysmal Nocturnal Hemoglobinuria in Older Patients with Unexplained Anemia and/or Cytopenia.Clin Lab. 2020 Sep 01;66(9):Authors: Ozdemir ZN, Ilhan O, Ozet G, Falay M, Yenerel M, Tuglular T, Turgut M, Guvenc B, Unal A, Ayyildiz O, Andic N, Hacihanefioglu A, Sahin F, Sencan M, Ali R, Ozsan GH, Yildirim R, Tiftik EN, Tombak A,...
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Circulating circRNA Has_Circ_0141633 Serves as a Potential Biomarker for Gastric Cancer.: Circulating circRNA Has_Circ_0141633 Serves as a Potential Biomarker for Gastric Cancer.Clin Lab. 2020 Sep 01;66(9):Authors: Yin G, Zheng S, Shan Y, Zhang J, Ying R, Kong WAbstract BACKGROUND: The current study aims to investigate the expression of circRNA has_circ_0141633 in the tissues and serum of patients with gastric cancer (GC). METHODS: RT-qPCR was used to detect the expression of has_circ_0141633...
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Chemoradiation in Lung Cancer: Effect on Levels of NGAL and Vitamin D in Serum.: Chemoradiation in Lung Cancer: Effect on Levels of NGAL and Vitamin D in Serum.Clin Lab. 2020 Sep 01;66(9):Authors: Dahiya K, Gupta K, Dhankhar R, Atri R, Goyal N, Dalal D, Pal S, Ahlawat R, Kumar SAbstract BACKGROUND: Mortality due to lung cancer is one of the growing concerns worldwide. Accurate and timely diagnosis is the key to treatment of this disease. Neutrophil gelatinase associated lipocalin (NGAL)...
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The Correlation between Blood HbA1c and HDL Subclasses in Patients with Metabolic Syndrome.: The Correlation between Blood HbA1c and HDL Subclasses in Patients with Metabolic Syndrome.Clin Lab. 2020 Sep 01;66(9):Authors: Xiao L, Tian Y, Wu J, Li N, Zhang C, Chen W, Long SAbstract BACKGROUND: Metabolic syndrome (MS) is characterized by a constellation of metabolic disorders. Hyperglycemia and dyslipidemia are the major risk factors of MS. Here we performed a study to explore the association...
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Acquired Combined Factor Deficiency: Case Report.: Acquired Combined Factor Deficiency: Case Report.Clin Lab. 2020 Sep 01;66(9):Authors: Acik DYAbstract BACKGROUND: Acquired hemophilia is a rare bleeding disorder. Difenacoum (superwarfarin), an antivitamin K anticoagulant, has been commonly used as a rodenticide. Factors II, VII, IX, and X are reduced as a result of this inhibition. METHODS: In this article, we have presented a case that had been exposed to superwarfarin according...
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Enhanced Serum miR-153-3p Promotes the Development of Knee Osteoarthritis by Targeting SOST.: Enhanced Serum miR-153-3p Promotes the Development of Knee Osteoarthritis by Targeting SOST.Clin Lab. 2020 Sep 01;66(9):Authors: Shen B, Wang S, Wang C, Li YAbstract BACKGROUND: The current study aims to identify the expression of serum miR-153-3p in knee osteoarthritis (KOA) patients, thereby evaluating its diagnostic value in clinic. METHODS: The KOA group was divided into mild group,...
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RIP6 Suppresses Tumor Cell Growth in Hepatocellular Carcinoma.: RIP6 Suppresses Tumor Cell Growth in Hepatocellular Carcinoma.Clin Lab. 2020 Sep 01;66(9):Authors: Zhong F, Wu Q, Xia G, Liu L, Yu TAbstract BACKGROUND: Receptor-interacting protein (RIP) has been shown to play a critical role in the development of cancer cells. Nevertheless, its functional role in hepatocellular carcinoma (HCC) progression is not fully understood. METHODS: Western blotting and qRT-PCR were used to detect...
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Serum HDL Associated Antioxidant Activity in Alzheimer's Disease: Paraoxonase1 and Dysfunctional HDL.: Serum HDL Associated Antioxidant Activity in Alzheimer's Disease: Paraoxonase1 and Dysfunctional HDL.Clin Lab. 2020 Sep 01;66(9):Authors: Varlibas F, Akhan O, Can M, Yuksel G, Gul ZBAbstract BACKGROUND: Human serum paraoxonase1 (PON1) is a high-density lipoprotein (HDL) associated antioxidant enzymes. We aimed to research the PON1 activity in Alzheimer's disease (AD) not accompanied with...
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Evaluation of Routine Blood Tests for Diagnosis of Suspected Coronavirus Disease 2019.: COVID-19 patients: lymphocytes ≤ 1.0 x 109/L; eosinophils ≤ 0.02 x 109/L; ferritin > 125% of upper reference limit (URL); LDH > 125% of URL; hsCRP > 80 mg/L; and D-dimer > 1.2 mg/L. Evaluation of Routine Blood Tests for Diagnosis of Suspected Coronavirus Disease 2019.Clin Lab. 2020 Sep 01;66(9):Authors: Santotoribio JD, Nuñez-Jurado D, Lepe-Balsalobre EAbstract BACKGROUND: Real-time reverse...
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Aberrant Expression of Cancer-Testis Antigen FBXO39 in Breast Cancer and its Clinical Significance.: Aberrant Expression of Cancer-Testis Antigen FBXO39 in Breast Cancer and its Clinical Significance.Clin Lab. 2020 Sep 01;66(9):Authors: Liu YC, Yan S, Liu DM, Pei DX, Li YWAbstract BACKGROUND: Cancer/testis antigen (CTA) is a class of antigen molecules expressed only in the germinal epithelium of testis and some tumor tissues. As an important CTA molecule, the expression of F-box protein...
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Resveratrol promotes secretion of wound healing related growth factors of mesenchymal stem cells originated from adult and fetal tissues.: Resveratrol promotes secretion of wound healing related growth factors of mesenchymal stem cells originated from adult and fetal tissues.Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):1160-1167Authors: Prakoeswa CRS, Rindiastuti Y, Wirohadidjojo YW, Komaratih E, Nurwasis, Dinaryati A, Lestari NMI, Rantam FAAbstract Non-healing wounds have demonstrated...
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Heerfordt-Waldenström syndrome, a rare presentation of sarcoidosis in a patient with old ocular toxoplasmosis.: Heerfordt-Waldenström syndrome, a rare presentation of sarcoidosis in a patient with old ocular toxoplasmosis.Infect Disord Drug Targets. 2020 Sep 08;:Authors: Mobini M, Ahmadzade-Amiri A, Ghasemian R, Torabizadeh Z, Fakhar MAbstract BACKGROUND: There are similarities between ophthalmic presentation of toxoplasmosis and sarcoidosis and there are some concerns of immunosuppressive...
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Heerfordt-Waldenström syndrome, a rare presentation of sarcoidosis in a patient with old ocular toxoplasmosis.: Heerfordt-Waldenström syndrome, a rare presentation of sarcoidosis in a patient with old ocular toxoplasmosis.Infect Disord Drug Targets. 2020 Sep 08;:Authors: Mobini M, Ahmadzade-Amiri A, Ghasemian R, Torabizadeh Z, Fakhar MAbstract BACKGROUND: There are similarities between ophthalmic presentation of toxoplasmosis and sarcoidosis and there are some concerns of immunosuppressive...
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Correlation between serum bilirubin levels and the severity as well as the prognosis of idiopathic pulmonary fibrosis: Chronic Respiratory Disease, Volume 17, Issue , January-December 2020. Bilirubin exerts antioxidant activity that has been associated with respiratory diseases. However, the relationship between serum bilirubin levels and idiopathic pulmonary fibrosis (IPF) is not clear. Therefore, in this study, we evaluated the relationship between serum bilirubin levels and the severity as well...
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Neutrophile Granulozyten im Tumormikromilieu – Feind oder Freund?: ZusammenfassungNeutrophile repräsentieren die häufigste Leukozytenpopulation und werden oftmals mit Entzündungen und mit der Bekämpfung von Infektionen in Verbindung gebracht. In den letzten Jahren ist das Interesse an der Rolle dieser Blutzellen bei der Karzinogenese in den Vordergrund gerückt. Eine erhöhte Zahl zirkulierender und den Tumor infiltrierender neutrophiler Granulozyten (tumorassoziierte Neutrophile, TAN) stellen jeweils...
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DIEP flap reconstruction as salvage option for Poland syndrome breast hypoplasia.: Poland syndrome is a congenital abnormality mostly associated with unilateral hypoplasia of the sternocostal head of pectoralis major, rib cage and upper limb abnormalities. It may include absent or hypoplastic breast can which have a significant psychological impact in female patients who often experience body image disorders. Mild cases can be improved with lipo-modelling, but traditional reconstruction options include...
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Estimation of Parkinson's disease severity using speech features and extreme gradient boosting: AbstractIn recent years, there is an increasing interest in building e-health systems. The systems built to deliver the health services with the use of internet and communication technologies aim to reduce the costs arising from outpatient visits of patients. Some of the related recent studies propose machine learning–based telediagnosis and telemonitoring systems for Parkinson's disease (PD). Motivated...
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Occupational physical activity, not leisure-time physical activity, is associated with increased high-sensitivity C reactive protein levels: ObjectiveThis study aims to explore the association between physical activity and high-sensitivity C reactive protein, based on different types of physical activity—occupational and leisure time.MethodsUsing cross-sectional data from the Korea National Health and Nutrition Examination Survey 2015–2018, we explored the association between different types of self-reported...
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Novel cellular immunotherapy using NKG2D CAR-T for the treatment of cervical cancer: Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Yan Zhang, Xing Li, Jun Zhang, Lin Mao
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Stachydrine promotes angiogenesis by regulating the VEGFR2/MEK/ERK and mitochondrial-mediated apoptosis signaling pathways in human umbilical vein endothelial cells: Publication date: November 2020Source: Biomedicine & Pharmacotherapy, Volume 131Author(s): Fei Zhou, Fei Liu, Juan Liu, Yu-Lin He, Qin-Mei Zhou, Li Guo, Cheng Peng, Liang Xiong
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The Role of Serum Adhesion Molecules s-ICAM-1 and s-VCAM-1 in Chronic Otitis Media Pathogenesis: A Prospective Controlled Study: AbstractThe aim of this study was to determine the levels of soluble intracellular adhesion molecule-1 (s-ICAM-1) and soluble vascular cell adhesion molecule- 1 (s-VCAM-1) in patients with chronic otitis media (COM) according to the disease profile and to compare with ears without otitis media. Eighty-nine patients had ear surgery were included in the study prospectively....
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Versatile design of compound vastus lateralis muscle and anterolateral thigh musculocutaneous perforator free flaps for customized reconstruction of complex skin and soft tissue defects in the extremities: AbstractBackgroundCompound anterolateral thigh flaps are popular for three‐dimensional reconstruction of complex soft tissue defects. We present our 10‐year experience using compound vastus lateralis (VL) muscle and anterolateral thigh musculocutaneous perforator (ALTP) flaps, and introduce three...
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Multicentric Castleman Disease Presenting as a Chylous Pleural Effusion: Publication date: Available online 10 September 2020Source: Pathology - Research and PracticeAuthor(s): Danny Epstein, Yaniv Zohar, David Ovadya, Hanna Ammouri, Ran Kremer, Noa Lavi, Inna Tzoran, Elias R. Andrawas, Erez Klein, Asaf Miller
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An astronomically dated record of Earths climate and its predictability over the last 66 million years: Much of our understanding of Earth's past climate comes from the measurement of oxygen and carbon isotope variations in deep-sea benthic foraminifera. Yet, long intervals in existing records lack the temporal resolution and age control needed to thoroughly categorize climate states of the Cenozoic era and to study their dynamics. Here, we present a new, highly resolved, astronomically dated, continuous...
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The hepatocyte clock and feeding control chronophysiology of multiple liver cell types: Most cells of the body contain molecular clocks, but the requirement of peripheral clocks for rhythmicity and their effects on physiology are not well understood. We show that deletion of core clock components REV-ERBα and REV-ERBβ in adult mouse hepatocytes disrupts diurnal rhythms of a subset of liver genes and alters the diurnal rhythm of de novo lipogenesis. Liver function is also influenced by nonhepatocytic...
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A molecular pore spans the double membrane of the coronavirus replication organelle: Coronavirus genome replication is associated with virus-induced cytosolic double-membrane vesicles, which may provide a tailored microenvironment for viral RNA synthesis in the infected cell. However, it is unclear how newly synthesized genomes and messenger RNAs can travel from these sealed replication compartments to the cytosol to ensure their translation and the assembly of progeny virions. In this study, we...
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Epigenetic Evolution of ACE2 and IL-6 Genes as Non-Canonical Interferon-Stimulated Genes Correlate to COVID-19 Susceptibility in Vertebrates [NEW RESULTS]: Current novel coronavirus disease (COVID-19) has spread globally within a matter of months. The virus establishes a success in balancing its deadliness and contagiousness, and causes substantial differences in susceptibility and disease progression in people of different ages, genders and pre-existing comorbidities. Since these host factors are...
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Determinants of telomere length across human tissues: Telomere shortening is a hallmark of aging. Telomere length (TL) in blood cells has been studied extensively as a biomarker of human aging and disease; however, little is known regarding variability in TL in nonblood, disease-relevant tissue types. Here, we characterize variability in TLs from 6391 tissue samples, representing >20 tissue types and 952 individuals from the Genotype-Tissue Expression (GTEx) project. We describe differences across...
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Transcriptomic signatures across human tissues identify functional rare genetic variation: Rare genetic variants are abundant across the human genome, and identifying their function and phenotypic impact is a major challenge. Measuring aberrant gene expression has aided in identifying functional, large-effect rare variants (RVs). Here, we expanded detection of genetically driven transcriptome abnormalities by analyzing gene expression, allele-specific expression, and alternative splicing from multitissue...
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High-Flow Oxygen with Capping or Suctioning for Tracheostomy Decannulation: Approximately 15% of patients undergoing mechanical ventilation receive a tracheostomy as part of their care, but experimental data regarding readiness for decannulation are limited. Evidence of decannulation readiness has been limited to expert opinion, survey studies, single-center experience,…
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Nonmetastatic, Castration-Resistant Prostate Cancer and Survival with Darolutamide: Nonmetastatic, castration-resistant prostate cancer is defined by rising levels of serum prostate-specific antigen (PSA) and an absence of detectable metastases on conventional imaging in patients receiving androgen-deprivation therapy. Patients with nonmetastatic, castration-resistant prostate…
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Eflornithine plus Sulindac for Prevention of Progression in Familial Adenomatous Polyposis: Familial adenomatous polyposis is a rare, autosomal dominant, hereditary colorectal cancer syndrome that is most commonly caused by pathogenic germline variants in the adenomatous polyposis coli (APC) gene. In its classic presentation, familial adenomatous polyposis is characterized by progressive…
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BIVV001 Fusion Protein as Factor VIII Replacement Therapy for Hemophilia A: Severe hemophilia A (defined as Prophylaxis with factor VIII products that have an extended half-life has advanced the treatment of severe hemophilia, in part by improving the control of bleeding, joint health, and quality of life, and by reducing treatment burden. However, residual burden still…
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Expression of Matrix Metalloproteinases and Their Tissue Inhibitors in Peripheral Blood Leukocytes and Plasma of Children with Nonalcoholic Fatty Liver Disease: Gene expression profiles of matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) were evaluated in peripheral blood leukocytes of children with nonalcoholic fatty liver disease (NAFLD). Gene expression patterns were correlated with their plasma protein counterparts, systemic parameters of liver injury, and selected markers...
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Isolated Laryngeal Tuberculosis: a Diagnostic Dilemma: AbstractLaryngeal tuberculosis is a rare condition, isolated laryngeal tuberculosis without pulmonary manifestations is even more rare. Patients usually presents with voice change, difficulty in swallowing and other constitutional symptoms. The symptoms and findings can look like malignancy in most of the cases. Here, we present a case of primary laryngeal tuberculosis without pulmonary tuberculosis. A 24 year old man who presented to us with...
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The Value of Preoperative Computed Tomography Angiography (CT-A) in Patients Undergoing Delayed Latissimus Dorsi Flap Breast Reconstruction after Axillary Lymph Node Dissection or Irradiation and Suspicion of Pedicle Injury.: The latissimus dorsi (LD) flap first described by Tansini in 1906 has proven to be a versatile resource in breast reconstruction remaining as one of the most popular reconstructive options. This flap is unmatched in reliability and its dissection is usually straightforward....
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Gene expression profile of epithelial-mesenchymal transition mediators in papillary thyroid cancer: AbstractPurposePlatelet derived growth receptor alpha (PDGFRA) promotes the epithelial-mesenchymal transition (EMT) in thyroid follicular cells and is linked to lymphatic metastases in papillary thyroid cancer (PTC). We probed the regulatory network of genes linked to PDGFRA and EMT, comparing matched patient primary tumor and metastatic specimens, as well as engineered cell lines and ex vivo primary...
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Use of metformin and aspirin is associated with delayed cancer incidence: Publication date: December 2020Source: Cancer Epidemiology, Volume 69Author(s): Joseph JY Sung, Jason MW Ho, Amy SM Lam, Sarah TY Yau, Kelvin KF Tsoi
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Combined fluorescence-guided surgery and photodynamic therapy for glioblastoma multiforme using cyanine and chlorin nanocluster: AbstractIntroductionGlioblastoma multiforme (GBM) is the most common primary intracranial malignancy; survival can be improved by maximizing the extent-of-resection. MethodsA near-infrared fluorophore (Indocyanine-Green, ICG) was combined with a photosensitizer (Chlorin-e6, Ce6) on the surface of superparamagnetic-iron-oxide-nanoparticles (SPIONs),...
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Lead-time bias does not falsify the efficacy of early salvage radiotherapy for recurrent prostate cancer: Radical prostatectomy (RP) is one of the leading primary treatment options for patients with prostate cancer (PCa) [1–3]. Depending on risk factors, up to 50% / 65% of the patients develop biochemical recurrence within five / ten years after RP, respectively [4,5]. For these patients, who are prone to systemic progression [6,7], salvage radiotherapy (SRT) with or without additional androgen deprivation...
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Non-excisional laser therapies for hemorrhoidal disease: a systematic review of the literature: AbstractNon-excisional laser therapies are emerging treatment for grades II and III hemorrhoidal disease (HD). However, so far, their efficiency is based on low-level evidence. Therefore, we aimed to systematically review the efficiency of non-excisional laser therapies for HD. MEDLINE/Pubmed, Web of science, Embase, and Cochrane were searched from database implementation until the April 17th, 2020. We...
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Combined treatment with acetazolamide and cisplatin enhances the chemosensitivity of human head and neck squamous cell carcinoma TU868 cells: Publication date: Available online 9 September 2020Source: Archives of Oral BiologyAuthor(s): Tao Jia, Sen-Xiang Ming, Qing-Qing Cao, Feng-Lei Xu
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Targeting NEK2 impairs oncogenesis and radioresistance via inhibiting the Wnt1/β-catenin signaling pathway in cervical cancer: NEK2, a serine/threonine kinase involved in mitosis, has been found to function in chromosome instability, tumor progression and metastasis, but its role in cervical cancer radioresistance remains unknown.
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NR4A3 Immunohistochemistry Reliably Discriminates Acinic Cell Carcinoma from Mimics: AbstractAcinic cell carcinoma (AciCC) harbors a recurrent t(4;9)(q13;q31) translocation, which leads to upregulation of Nuclear Receptor Subfamily 4 Group A Member 3 (NR4A3). Previous work on tissue microarrays suggests that NR4A3 immunohistochemistry (IHC) may be useful in the diagnosis of AciCC. Thus far, only a single study has evaluated the utility of NR4A3 immunohistochemistry (IHC) in the diagnosis of AciCC,...
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Evaluation of air polishing with a sterile powder and mechanical debridement during regenerative surgical periimplantitis treatment: a study in dogs: AbstractObjectivesTo evaluate the effectiveness of mechanical debridement and/or air polishing on the healing of ligature-induced buccal periimplantitis dehiscence defects in dogs. Material and methodsForty-eight implants were placed in the mandibles of twelve beagle dogs, and periimplantitis was induced for 2 months using ligatures....
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Diagnostic performance of mobile cone beam computed tomography versus conventional multi-detector computed tomography in orbital floor fractures: a study on human specimens: The aim of this study was to evaluate the diagnostic accuracy of mobile cone beam computed tomography (MCBCT) versus multi-detector computed tomography (MDCT) in orbital floor fractures. Twenty-four fresh cadaver heads were used, and one orbital floor was fractured for each head by transconjunctival approach. MDCT and MCBCT were...
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Evaluation of Dental Pulp Stem Cell Heterogeneity and Behaviour in 3D Type I Collagen Gels: Dental pulp stem cells (DPSCs) are increasingly being advocated for regenerative medicine-based therapies. However, significant heterogeneity in the genotypic/phenotypic properties of DPSC subpopulations exists, influencing their therapeutic potentials. As most studies have established DPSC heterogeneity using 2D culture approaches, we investigated whether heterogeneous DPSC proliferative and contraction/remodelling...
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Mitogen-activated protein kinases are involved in cucurbitacin D-induced antitumor effects on adult T-cell leukemia cells: SummaryAdult T cell leukemia (ATL) is an aggressive and malignant blood disease. We previously reported that steroid-structured cucurbitacin D (CuD) induces apoptosis in ATL cells. In this study, we investigated the effects of mitogen-activated protein kinase (MAPK) signaling inhibitors on CuD-induced cell death in peripheral blood lymphocytes (PBLs) isolated from ATL/acute lymphoblastic...
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Transmission of SARS-CoV-2 in children aged 0 to 19 years in childcare facilities and schools after their reopening in May 2020, Baden-Württemberg, Germany: We investigated data from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected 0–19 year olds, who attended schools/childcare facilities, to assess their role in SARS-CoV-2 transmission after these establishments' reopening in May 2020 in Baden-Württemberg, Germany. Child-to-child transmission in schools/childcare facilities...
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R0 resection following chemo (radio)therapy improves survival of primary inoperable pancreatic cancer patients. Interim results of the German randomized CONKO-007± trial: AbstractPurposeChemotherapy with or without radiotherapy is the standard in patients with initially nonmetastatic unresectable pancreatic cancer. Additional surgery is in discussion. The CONKO-007 multicenter randomized trial examines the value of radiotherapy. Our interim analysis showed a significant effect of surgery, which may...
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Igg4 Related Disease of Skull Base—A Diagnostic Challenge: AbstractIgG4 related disease (IgG4-RD) is a fibro-inflammatory disease, with tendency to affect any organ of the body. However, few cases affecting the skull base have been reported in literature. We report one such case in an elderly male, who presented us with a mass lesion in the skull base that mimicked nasopharyngeal malignancy. On thorough clinical history, examination, and investigations, IgG4 Related disease was diagnosed and treatment...
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Entwicklung auditiver Verarbeitungs- und Wahrnehmungsleistungen mit und ohne AVWS im Grundschulalter
Entwicklung auditiver Verarbeitungs- und Wahrnehmungsleistungen mit und ohne AVWS im Grundschulalter: LaryngorhinootologieDOI: 10.1055/a-1241-4599Hintergrund Ob sich die an unauffälligen Kindern beschriebenen Reifungsprozesse des zentralen Hörsystems auch an Kindern mit auditiven Verarbeitungs- und Wahrnehmungsstörungen (AVWS) im Grundschulalter nachweisen lassen, sollte an 2 Schülerjahrgängen (1. und 4. Klasse) im Kontrollgruppenvergleich untersucht werden. Material und Methoden In die...
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Osseointegration of a novel injection molded 2-piece ceramic dental implant: a study in minipigs: AbstractObjectivesThis study compared the osseointegrative potential of a novel injection molded zirconia dental implant (Neodent Zi ceramic implant, test) and a commercially available titanium implant (Neodent Alvim implant, control) in terms of histomorphometrically derived bone-to-implant contact (BIC), first bone-to-implant contact (fBIC), and the ratio of bone area to total area (BATA) around the...
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Development and internal validation of prediction models for persistence of self-reported orofacial pain in the follow-up of patients with myofascial pain: AbstractObjectivesTo identify predictors in patient profiles, and to develop, internally validate, and calibrate prediction models for the persistence of self-reported orofacial pain at the 6-month and 12-month follow-up in patients with myofascial pain. Materials and methodsA cohort of 63 adult patients with moderate to severe...
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New technique: the use of the THRIVE sequence in the follow-up of patients who received endovascular intracranial aneurysm treatment: AbstractPurposeTo determine the diagnostic accuracy of 3D time of flight MR angiography (TOF-MRA), contrast enhanced MR angiography (CE-MRA), and T1-weighted high-resolution isotropic volume examination (THRIVE) at 3 T for the evaluation of intracranial aneurysm occlusion after endovascular treatment and to evaluate the usability of the THRIVE sequence in endovascular...
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Gene networks constructed through simulated treatment learning can predict proteasome inhibitor benefit in Multiple Myeloma: Purpose: Proteasome inhibitors are widely used in treating Multiple Myeloma, but can cause serious side effects and response varies between patients. It is therefore important to gain more insight into which patients will benefit from proteasome inhibitors. Experimental Design: We introduce Simulated Treatment Learned signatures (STLsig), a machine learning method to identify...
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Radiological Anatomy of the Olfactory Fossa: Is Skull Base Anatomy Really Ever "Safe"?: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716690Objective Computed tomography (CT) is a powerful tool for delineating the anatomy of the anterior skull base. The goal of this study is to further characterize the relevant anatomical features of this area, along with other parameters important for endoscopic sinus surgery. Design Retrospective case review. Setting Tertiary care hospital....
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Morphometric Study of the Posterior Fossa: Identification of Practical Parameters for Tailored Selection of Surgical Routes to the Petroclival Region: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716691Introduction The petroclival region is an integral part of the skull base. It can harbor different pathologies and provides access to the petroclival junction and cerebellopontine angle. We present the results of the morphometric analysis of the posterior fossa and a prediction model to enable skull...
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Size Matters: Rethinking of the Sizing Classification of Pituitary Adenomas Based on the Rates of Surgery: A Multi-institutional Retrospective Study of 29,651 Patients: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716673Objective Pituitary adenomas are historically classified into microadenoma or macroadenomas based on size less than or greater than/equal to 1c m. "Giant" adenomas describe tumors ≥4 cm. The aim of this study is to present an evidence-based approach to size classification based...
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Endoscopic Transnasal Resection of Midline Skull Base Meningiomas: Tumor Consistency and Surgical Outcomes: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1714111Background The endoscopic transnasal approach (ETA) has proven to be of great value in the resection of midline skull base meningiomas when compared with traditional approaches. Our objective was to assess tumor consistency in relation to surgical outcomes for midline meningiomas (MMs) resected using ETA. Methods Radiological preoperative...
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Beyond Antoni: A Surgeon's Guide to the Vestibular Schwannoma Microenvironment: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716688Introduction Vestibular schwannomas (VS) are histologically benign tumors arising from cranial nerve VIII. Far from a homogenous proliferation of Schwann cells, mounting evidence has highlighted the complex nature of the inflammatory microenvironment in these tumors. Methods A review of the literature pertaining to inflammation, inflammatory molecular pathways,...
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Anatomical Limits of the Endoscopic Contralateral Transmaxillary Approach to the Petrous Apex and Petroclival Region: J Neurol Surg B Skull BaseDOI: 10.1055/s-0040-1716693Objectives This study aimed to establish the anatomical landmarks for performing a contralateral transmaxillary approach (CTM) to the petrous apex (PA) and petroclival region (PCR), and to compare CTM with a purely endoscopic endonasal approach (EEA). Design EEA and CTM to the PA and PCR were performed bilaterally in eight...
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The Variable Appearance of Third Ventricular Colloid Cysts: Correlation with Histopathology and the Risk of Obstructive Ventriculomegaly [ADULT BRAIN]: BACKGROUND AND PURPOSE:While third ventricular colloid cysts may present as an incidental finding, they also harbor the potential to cause ventricular obstruction and sudden death. Herein we analyze the relationship between imaging appearance and the risk of obstructive ventriculomegaly.MATERIALS AND METHODS:This is a retrospective review of the MR...
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Diffuse Leptomeningeal Glioneuronal Tumor of Childhood [PEDIATRICS]: SUMMARY:Diffuse leptomeningeal glioneuronal tumor is a newly defined entity under the neuronal and mixed neuronal-glial tumors category in the 2016 World Health Organization classification of brain tumors. In this series, we report clinical, radiologic, and histologic findings in 7 cases of diffuse leptomeningeal glioneuronal tumor. Our cases and literature review indicate that the most characteristic imaging finding is diffuse...
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Maternal Anxiety and Depression during Late Pregnancy and Newborn Brain White Matter Development [PEDIATRICS]: BACKGROUND AND PURPOSE:Anxiety and depression during pregnancy have been associated with an increased risk of adverse neurodevelopmental outcomes in offspring. We aimed to study the in utero effects of maternal anxiety and depression on early brain development.MATERIALS AND METHODS:Pregnant women were recruited at ~36 weeks of gestation for this prospective study. They were assessed for...
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Fetal Exposure to MR Imaging: Long-Term Neurodevelopmental Outcome [PEDIATRICS]: BACKGROUND AND PURPOSE:Very few studies have investigated long-term neurodevelopment of children exposed to MR imaging antenatally. Thus, the purpose of our study was to evaluate long-term neurodevelopmental outcomes of children exposed to MR imaging during pregnancy.MATERIALS AND METHODS:We conducted a historical prospective cohort study in a single tertiary medical center. Women exposed to 1.5T noncontrast MR imaging...
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Ameliorating effect of CpG-ODN (oligodeoxynucleotide) against radiation-induced lung injury in mice: AbstractWhile radiation-induced lung injury (RILI) is known to be progressed by Th2 skewed, pro-inflammatory immune response, there have been few therapeutic attempts through Th1 immune modulation. We investigated whether the immunostimulant CpG-oligodeoxynucleotide (CpG-ODN) would be effective against RILI by way of measuring reactive oxygen species (ROS) and nitric oxides (NO), histopathology, micro-three-dimensional...
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Pulmonary Surfactants: a New Therapeutic Target in Asthma: AbstractPurpose of ReviewLung tissues are highly susceptible to airway inflammation as they are inevitably exposed to inhaled pathogens and allergens. In the lungs, clearance of infectious agents and regulation of inflammatory responses are important for the first-line defense, where surfactants play a role in host defense mechanisms. In this review, clinical significance of pulmonary surfactants in asthma has been highlighted. ...
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Phase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer: British Journal of Cancer, Published online: 11 September 2020; doi:10.1038/s41416-020-01041-xPhase 1 study of mTORC1/2 inhibitor sapanisertib (TAK-228) in advanced solid tumours, with an expansion phase in renal, endometrial or bladder cancer
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NTCP model for hypothyroidism after supraclavicular-directed radiation therapy for breast cancer: Breast cancer is the most common malignancy among women and second most common in the world, with approximately 1.67 million new cases diagnosed and half a million deaths worldwide in 2012 [1]. The standard treatment regimen for breast cancer varies based on stage and clinical presentation, but typically involves surgery, radiation therapy (RT), and systemic therapy. For patients at high-risk for locoregional...
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1Review Exp Ther Med. 2020 Oct;20(4):3379-3382. doi: 10.3892/etm.2020.8972. Epub 2020 Jul 7.Ocular cicatricial pemphigoid (Review)Daniel Constantin Branisteanu 1, Gabriela Stoleriu 2, Daciana Elena Branisteanu 3, Daniel Boda 4, Catalina Ioana Branisteanu 5, Minela Aida Maranduca 6, Andreea Moraru 1, Horia Tudor Stanca 7, Mihail Zemba 7, Florian Balta 7Affiliations expandPMID: 32905166 PMCID: PMC7465597 DOI: 10.3892/etm.2020.8972AbstractOcular cicatricial pemphigoid is a particular form of mucous...
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