To the Editor: Acromegaly is caused by a growth hormone–secreting pituitary tumor, and its signs link to increased growth hormone–dependent hepatic insulin-like growth factor I (IGF-I) synthesis. A eucaloric very-low-carbohydrate ketogenic diet ( We conducted a proof-of-concept study involving 11…
Thu May 28, 2020 03:00
A 63-year-old woman was referred to the endocrinology department for consultation regarding multiple fractures. Her chief concerns were progressively worsening pain in both ankles and difficulty walking. She needed crutches or a cane for support. . . .
Thu May 28, 2020 03:00
Phosphatidate phosphatase-1 (lipin-1) is encoded by LPIN1 gene. Lipin-1 deficiency has been reported as the second most common cause of early-onset rhabdomyolysis after primary fatty acid oxidation disorders. We report a case of a 32-year-old Sri Lankan female with a history of more than 10 episodes of rhabdomyolysis and exercise intolerance since childhood. These episodes were triggered by infections and exercise. A temporal relationship between the acute episodes and use of drugs such as theophylline,...
Thu May 28, 2020 09:05
Cancer Informatics, Volume 19, Issue , January-December 2020. In recent years, due to an increase in the incidence of different cancers, various data sources are available in this field. Consequently, many researchers have become interested in the discovery of useful knowledge from available data to assist faster decision-making by doctors and reduce the negative consequences of such diseases. Data mining includes a set of useful techniques in the discovery of knowledge from the data: detecting hidden...
Thu May 28, 2020 09:28
H9N2 avian influenza virus has spread worldwide, and vaccination with an inactivated virus is currently the major prevention method in China. To further understand the effect of the selection pressure from ant...
Wed May 27, 2020 03:00
Abstract The most frequent cancer worldwide is skin cancer, occurring at epidemic rates in countries exposed to high levels of chronic ultraviolet radiation such as Australia and New Zealand (ANZ). Australia has the highest incidence of non‐melanoma skin cancer (NMSC) in the world. NMSC is predominantly a cancer of the middle aged or elderly and accounts for considerable consulting and treatment time in most radiation oncology departments. Many patients also suffer from medical co‐morbidity, an...
Wed May 27, 2020 12:43
Abstract The aim of this study is to evaluate the efficacy of the pericapsular nerve group block and local infiltration analgesia (LIA) combination as the only anesthesia technique for the total hip arthroplasty (THA). We considered the anesthetic plan, postoperative analgesia, hospital length of stay, functional recovery, bleeding, complications and the adverse events. We reported 10 ASA I–II patients admitted for elective primary THA, receiving LIA during (5) and at the end...
Thu May 28, 2020 11:50
Abstract Purpose Compared with open thoracotomy, minimally invasive esophagectomy (MIE) methods, such as transhiatal or thoracoscopic esophagectomy, likely have lower morbidity. However, the relationship between intraoperative fluid management and postoperative complications after MIE remains unclear. Thus, we investigated the association of cumulative intraoperative fluid balance and postoperative complications in patients undergoing...
Thu May 28, 2020 11:50
Abstract Transesophageal echocardiography (TEE) is a well-established procedure, but serious complications may occur. This systematic review and meta-analysis assessed the utility of videolaryngoscopy-assisted technique in TEE probe insertion. We performed a systematic search in MEDLINE, EMBASE, CENTRAL, and ICTRP. We included RCTs comparing TEE probe insertion techniques assisted with videolaryngoscopy and with any other insertion technique in adult patients. Primary outcome...
Thu May 28, 2020 11:50
Abstract Purpose Propofol clearance can be reduced when cardiac output (CO) is decreased. This clearance reduction may alter the pharmacokinetics of propofol and worsen the predictive performance of target-controlled infusion (TCI) of propofol. The head-down position (HDP) and CO2 pneumoperitoneum, which are required for robotic-assisted laparoscopic prostatectomy (RALP), may cause changes in CO. We investigated the predictive...
Thu May 28, 2020 11:50
Abstract Purpose Our objective was to examine the association between preoperative cognitive status and postoperative recovery from anesthesia. Methods We included patients (70–91 years old) from the Mayo Clinic Study of Aging who received general anesthesia and were admitted to the postanesthesia care unit from January 1, 2010 through...
Thu May 28, 2020 11:50
Abstract Background Continuous femoral nerve block (FNB) has been effectively used after total hip arthroplasty (THA). Recently the anterior approach to quadratus lumborum block (QLB) has been shown to produce postoperative pain relief after THA. Continuous QLB would benefit from a catheter insertion site that is farther away from the surgical site compared with continuous FNB. In this randomized controlled study, we compared...
Thu May 28, 2020 11:50
Pregnant women and their unborn babies are at increased risk of complications as a result of flu, yet uptake of the flu vaccination in the UK remains low. Digital interventions have proven effectiveness in cha...
Thu May 28, 2020 03:00
Peripheral nerves are constant targets of traumatic injury which may result in neurotmesis and which invariably requires surgical treatment. In view of this, tissue engineering studies developed biomaterials w...
Thu May 28, 2020 03:00
J Neurol Surg B Skull Base 2020; 81: 213-215DOI: 10.1055/s-0040-1712527Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals:Table of contents | Full text
Wed May 27, 2020 02:00
Abstract BACKGROUND Nowadays robotic platform is widespread in general surgery, urology and gynecology. Combined surgery may represent an alternative to sequential procedures and it allow the treatment, at the same time, of coexisting lesions; in this perspective, full‐robotic multiorgan surgery is starting to gain interest from surgeons worldwide. METHODS Between April and June 2019, two patients presenting with synchronous colorectal and kidney cancers underwent respectively full‐robotic...
Wed May 27, 2020 17:29
Abstract Airway epithelial barrier dysfunction is frequently observed in asthma and may have important implications. The physical barrier function of the airway epithelium is tightly interwoven with its immunomodulatory actions, while abnormal epithelial repair responses may contribute to remodelling of the airway wall. We propose that abnormalities in the airway epithelial barrier play a crucial role in the sensitization to allergens and pathogenesis of asthma. Many of the identified susceptibility...
Wed May 27, 2020 13:05
Abstract A novel human coronavirus(SARS‐CoV‐2) causing a severe acute respiratory syndrome, coronavirus disease 2019 (COVID‐19), was reported in Wuhan, China at the end of 2019(Wang, Horby, Hayden, & Gao,2020; Khan, Ali, Siddique, Nabi, 2020).The infectionhas an estimated incubation period of 1‐14 days and its clinical manifestations and symptoms include cough, fever and shortness of breath (Zhuet al., 2020).
Wed May 27, 2020 13:39
Abstract Globally, it has been estimated that there were around 18.1 million new cases of cancer at all sites in 2018, with 9.6 million deaths from the disease (Bray et al., 2018; Ferlay et al., 2019). As such, the mortality rate remains high, in spite of advances in treatment over the past few decades. Cancer is a genetic disease (Hanahan & Weinberg, 2011). Pinpointing key alterations in the cancer genome is, therefore, fundamental for our understanding of disease mechanisms, identifying druggable...
Wed May 27, 2020 13:35
Abstract Background Photobiomodulation has proven to be effective in different painful conditions. Objectives To assess the effect of photobiomodulation for pain management in burning mouth syndrome (BMS) patients, besides analysing the impact on different aspects of quality of life. Methods A randomized, single blind, clinical trial was performed among 20 patients with BMS. Photobiomodulation was applied in the study group (n=10) with a dose of 12 J/cm2 during 10 sessions, comparing...
Wed May 27, 2020 13:34
Abstract Coronavirus disease 19 (Covid‐19) was declared a pandemic by the World Health Organization on March 11th, 2020 (https://www.who.int/emergencies/diseases/novel-coronavirus-2019/events-as-they-happen). As of May 19th, 2020, approximately 4,731,458 cases of contamination and 316,169 deaths from Covid‐19 were recorded (https://who.sprinklr.com).
Wed May 27, 2020 13:29
Abstract Objective Troublesome hot flushes and night sweats (HFNS) are experienced by many women after treatment for breast cancer, impacting significantly on sleep and quality of life. Cognitive behavioural therapy (CBT) is known to be effective for the alleviation of HFNS. However, it is not known if it can effectively be delivered by specialist nurses. We investigated whether group CBT delivered by breast care nurses (BCNs) can reduce the impact of HFNS. Methods We recruited women with...
Wed May 27, 2020 22:59
Abstract Objective Insomnia is a significant concern among African‐American breast cancer survivors (BCS). Social constraints (SC)‐ receiving unsupportive or critical responses when expressing trauma‐related emotions‐ and fear of recurrence (FOR) have been associated with insomnia. We examined FOR as a mediator in the relationship between SC and insomnia in African‐American BCS. We hypothesized a direct effect of SC on insomnia, and an indirect effect of SC on insomnia through FOR. Methods...
Wed May 27, 2020 22:59
Wed May 27, 2020 11:00
Authors: Marialetizia Palomba, Michela Paoletti, Stephen C. Webb, Giuseppe Nascetti and Simonetta Mattiucci.Parasite Vol. 27 , page 39Published online: 26/05/2020 Keywords: Anisakis simplex (s. s.) ; A. pegreffii ; A. berlandi ; Diagnostic markers ; Metallopeptidase nas 10 nDNA ; ARMS-PCR.
Tue May 26, 2020 03:00
Authors: Susumu Ohtsuka, Wojciech Piasecki, Norshida Ismail and Ahmad Syazni Kamarudin.<br />Parasite Vol. 27 , page 40<br />Published online: 28/05/2020<br /> Keywords: Brachiella ; Charopinopsis ; Eobrachiella ; Lernaeopodidae ; Malaysia.<img src="http://feeds.feedburner.com/~r/edp_parasite/~4/fFeNAkJfLY4" height="1" width="1" alt=""/>
Thu May 28, 2020 03:00
Abstract Phaeochromocytomas and paragangliomas (PPGL) are rare neuroendocrine tumours with a hereditary background in over one third of patients. Mutations in succinate dehydrogenase (SDH) genes increase the risk for PPGLs and several other tumours. Mutations in subunit B (SDHB) in particular are a risk factor for metastatic disease, further highlighting the importance of identifying SDH mutations for patient management. Genetic variants of unknown significance, where implications for the patient...
Wed May 27, 2020 21:55
New Findings What is the central question of this study? Fire service instructors are frequently exposed to live fire scenarios, representing the most extreme chronic occupational heat exposure. These individuals report a series of unique health issues. We sought to identify whether the number of exposures completed was associated with inflammatory and immunological markers and symptoms of ill health. What is the main finding and its importance? Fire service instructors exhibit greater...
Wed May 27, 2020 16:46
Background: No consensus exists on the selection of procedures for the treatment of submucous cleft palate, with scarce reports on long-term outcomes from single-surgeon experience. This study assessed the outcomes of using extended indication criteria of Furlow palatoplasty as the first-line procedure for the management of submucous-cleft-palate-associated velopharyngeal insufficiency. Methods: Consecutive nonsyndromic patients with submucous cleft palate (n = 216) treated by a single...
Mon May 25, 2020 03:00
Background: Traumatic muscle loss often results in poor functional restoration. Skeletal muscle injuries cannot be repaired without substantial fibrosis and loss of muscle function. Given its regenerative properties, we evaluated outcomes of fetal tissue-derived decellularized matrix for skeletal muscle regeneration. We hypothesized that fetal matrix would lead to enhanced myogenesis and suppress inflammation and fibrosis. Methods: Composite tissue comprised of dermis, subcutaneous...
Mon May 25, 2020 03:00
Background: Common peroneal neuropathy (CPN) shares the same pathophysiology as carpal tunnel syndrome (CTS). However, management is often delayed due to the traditional misconception of recognizing foot drop as the defining symptom for diagnosis. We believe recognizing CPN before foot drop can relieve pain and help improve quality of life. Methods: One hundred and eighty five patients who received surgical CPN decompression between 2011 and 2017 were included. The mean follow up time...
Mon May 25, 2020 03:00
Purpose: Treatment outcomes of Dupuytren’s disease depend largely on degree of contracture and biologic severity. Longitudinal assessment of each is crucial for effective care and long-term outcome assessment. Ideally, each Dupuytren patient should have interval evaluations on an ongoing basis. Because of the large number of Dupuytren patients, it would be impractical and costly for health care professionals to examine every Dupuytren patient in person on a regular basis. Patient-based evaluations...
Mon May 25, 2020 03:00
Background: Anecdotally, faculty report that independent residents’ operative skills differ from those of their integrated peers. This study compared operative competency between integrated (PGY4-PGY6) and independent plastic surgery residents. Methods: We compared independent (PGY1-3) and integrated (PGY4-6) plastic surgery residents at our institution using operative performance data from the Operative Entrustability Assessment (OEA), a validated 5-point assessment tool that provides...
Mon May 25, 2020 03:00
Background: Facial allotransplantation including the temporo-mandibular joints (TMJ) may improve the functional outcomes in face transplant candidates who have lost or damaged this joint. Methods: Linear and angular measurements were taken in hundred dry skulls and mandibles, and in hundred 3D-reconstructed facial CT-scans, to determine the variability of the TMJ, glenoid fossa and mandible. A vascular study was performed in 6 fresh cadaveric heads, followed by harvest of the face allograft...
Mon May 25, 2020 03:00
Background: We sought to determine the reliability of the Soong classification, which relates the position of the implant to the watershed line of the distal radius, for predicting flexor tendinopathy in distal radius fractures treated with volar plate fixation. Methods: Medical records were reviewed, including: demographics, fracture and operative characteristics, tendon-related complications, and radiographic outcomes. 659 distal radius fractures were reviewed with a mean duration...
Mon May 25, 2020 03:00
Introduction: Type 1 internal hemipelvectomies and total sacrectomies cause significant biomechanical instability, demanding pelvic ring reconstruction for ambulation and torso support. Previously described methods include autografts, allografts and implants, commonly with poor long-term outcomes. We hypothesized that the free fibula flap (FFF) for spinopelvic reconstruction is safe and effective, associated with a high bony union rate and superior functional outcomes. Methods: We performed...
Mon May 25, 2020 03:00
Background: Maxillofacial reconstruction with vascularized bone restores facial contour and provides structural support and a foundation for dental rehabilitation. Routine implant placement in such cases, however, remains uncommon. This study aims to determine dental implant survival in patients undergoing vascularized maxillary or mandibular reconstruction through a systematic review of the literature. Methods: Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses...
Mon May 25, 2020 03:00
Objective: Current methods to analyze three-dimensional (3D) photography do not quantify intracranial volume (ICV), an important metric of development. This study presents the first non-invasive, radiation-free, accurate and reproducible method to quantify ICV from 3D photography. Methods: In this retrospective study, cranial bones and head skin were automatically segmented from CT images of 575 subjects without cranial pathology (average age 5 ± 5 years; range 0-16 years). The ICV...
Mon May 25, 2020 03:00
Hereditary cancer syndromes, which account for approximately 10% of all cancers, serve as powerful models for the practice of precision medicine. The identification of genes that are associated with seemingly rare cancer-predisposition syndromes often provides insights regarding aspects of normal…
Thu May 28, 2020 03:00
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