GDNF neurotrophic factor signaling determines the fate of dermal fibroblasts in wound‐induced hair neogenesis and skin regeneration

xlomafota13 shared this article with you from Inoreader GDNF neurotrophic factor signaling determines the fate of dermal fibroblasts in wound‐induced hair neogenesis and skin regeneration Via Experimental Dermatology ABSTRACT We propose that GDNF, a glial cell line-derived neurotrophic factor, can promote hair follicle neogenesis and skin regeneration after wounding by directing the fate of dermal fibroblasts. Our hypothesis is largely based on detailed GDNF and receptor analysis during skin regenerative stages, as well as the induction of GDNF receptors after wounding between the pro-regenerative Spiny mouse (genus Acomys) and its less regenerative descendant, the House mouse (Mus musculus). To characterize the GDNF-target cells, we will conduct a series of lineage-tracing experiments in conjunction with single-cell RNA and Assay for Transposase-Accessible Chromatin sequencing experiments. The heterogenetic dynamics of skin regeneration have yet to be fully defined, and this research will help to advance the fields of regenerative medicine and biology. Finally, we believe that stimulating the GDNF signaling pathway in fibroblasts from less-regenerative animals, such as humans, will promo te skin regeneration, morphogenesis, and scarless wound healing. View on the web Inoreader. Take back control of your news feed. Follow us on Twitter and Facebook.