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Τρίτη 3 Οκτωβρίου 2017

How linear response shaped models of neural circuits and the quest for alternatives

Publication date: October 2017
Source:Current Opinion in Neurobiology, Volume 46
Author(s): Tim Herfurth, Tatjana Tchumatchenko
In the past decades, many mathematical approaches to solve complex nonlinear systems in physics have been successfully applied to neuroscience. One of these tools is the concept of linear response functions. However, phenomena observed in the brain emerge from fundamentally nonlinear interactions and feedback loops rather than from a composition of linear filters. Here, we review the successes achieved by applying the linear response formalism to topics, such as rhythm generation and synchrony and by incorporating it into models that combine linear and nonlinear transformations. We also discuss the challenges encountered in the linear response applications and argue that new theoretical concepts are needed to tackle feedback loops and non-equilibrium dynamics which are experimentally observed in neural networks but are outside of the validity regime of the linear response formalism.



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