Frequent oncogenic BRAF V600E mutation in odontogenic keratocyst

Since the term odontogenic keratocyst (OKC) has been re-classified several times between cyst and tumor due to a debate over biological behaviors and oncogenic mutation of OKC [1,2]. Although a number of treatment methods have been developed in addition to simple enucleation, surgical approaches are often limited owing to the high recurrence of OKC as well as its locally destructive behavior [3]. While many targeted therapeutics for oncogenic mutation have become widely available recently, the molecular background of OKC and non-invasive therapeutic approaches based on oncogenic mutation have not been widely studied.

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