Prefrontal cortical specific differences in behavior and synaptic plasticity between adolescent and adult mice

Adolescence is a highly vulnerable period for the emergence of major neuropsychological disorders and is characterized by decreased cognitive control and increased risk-taking behavior and novelty seeking. The prefrontal cortex (PFC) is involved in the cognitive control of impulsive and risky behavior. Although the PFC is known to reach maturation later than other cortical areas, little information is available regarding the functional changes from adolescence to adulthood in PFC , particularly compared to other primary cortical areas. This study aims to understand the development of PFC-mediated, compared to non PFC-mediated, cognitive functions. Towards this aim, we performed cognitive behavioral tasks in adolescent and adult mice, and subsequently investigated synaptic plasticity in two different cortical areas. Our results showed that adolescent mice exhibit impaired performance in PFC-dependent cognitive tasks compared to adult mice, while their performance in non-PFC dependent tasks is similar to that of adults. Furthermore, adolescent mice exhibited decreased long-term potentiation (LTP) within upper layer synapses of the PFC, but not the barrel cortex (BC). Blocking GABA_A receptor function significantly augments LTP in both the adolescent and adult PFC. No change in intrinsic excitability of PFC pyramidal neurons was observed between adolescent and adult mice. Finally, increased expression of the NR2A subunit of the NMDA receptors is found only in the adult PFC, a change that could underlie the emergence of LTP. In conclusion, our results demonstrate physiological and behavioral changes during adolescence that are specific to the PFC and could underlie the reduced cognitive control in adolescents.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2mYZMOD