Objectives: Epidermal growth factor receptor (EGFR) and c-MET are tyrosine kinase growth factor receptors implicated in gastric cancer (GC), and their pathways appear to be interdependent. The aim of this study was to investigate the prognostic value of EGFR and c-MET protein overexpression by immunohistochemistry in Canadian patients with resected GC and correlate it with clinicopathologic characteristics and overall survival (OS). Materials and Methods: Tissue microarray blocks were constructed from 120 resected GCs stained with EGFR and c-MET and scored semiquantitatively (0 to 3+). Each receptor's expression was compared with clinicopathologic characteristics and survival. Descriptive statistics, Kaplan–Meyer, and Cox regression were used for statistical analyses. Results: Of the 113 interpretable cases, overexpression of EGFR and c-MET was noted in 17 (15%) and 65 (57%), respectively; coexpression of EGFR and c-MET was observed in 12 (10%) of GC. EGFR and c-MET overexpression correlated with poor OS: median 13 versus 30 months in EGFR positive versus negative GC (hazard ratio [HR]=1.67, P=0.11); 27 versus 49 months in c-MET positive versus negative GC (HR=1.17, P=0.49), respectively. GC coexpressing EGFR and c-MET was significantly correlated with poor survival: 12 versus 29 months in double-positive versus rest of tumors both in univariate (HR=2.62, P=0.003) and multivariate analyses (HR=2.58, P=0.01). Conclusions: This study describes the prevalence and prognostic value of EGFR and c-MET in a Canadian population of patients undergoing curative intent resection for GC. Both c-MET and EGFR overexpression trended toward poor OS, but only the group with EGFR+/c-MET+ GC reached statistical significance on multivariate analysis.
from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2j0Ud0C
Αρχειοθήκη ιστολογίου
-
►
2023
(269)
- ► Φεβρουαρίου (133)
- ► Ιανουαρίου (136)
-
►
2022
(2046)
- ► Δεκεμβρίου (165)
- ► Σεπτεμβρίου (161)
- ► Φεβρουαρίου (165)
-
►
2021
(3028)
- ► Δεκεμβρίου (135)
- ► Σεπτεμβρίου (182)
- ► Φεβρουαρίου (324)
-
►
2020
(1051)
- ► Δεκεμβρίου (292)
- ► Σεπτεμβρίου (60)
- ► Φεβρουαρίου (28)
-
►
2019
(2277)
- ► Δεκεμβρίου (18)
- ► Σεπτεμβρίου (54)
- ► Φεβρουαρίου (89)
-
►
2018
(26280)
- ► Δεκεμβρίου (189)
- ► Φεβρουαρίου (6130)
- ► Ιανουαρίου (7050)
-
▼
2017
(33948)
-
▼
Δεκεμβρίου
(6715)
-
▼
Δεκ 07
(405)
- A new T2 lesion in a patient with the clinically i...
- Multimodality Treatment of Intradural Extramedulla...
- Does radiotherapy prior to surgery improve long te...
- Downregulation of Caspase 8 in a group of Iranian ...
- Cytological diagnosis of a rare case of cutaneous ...
- Lymphoepithelioma-like Carcinoma of the Uterine Ce...
- Bone Marrow Edema Syndrome Of The Medial Femoral C...
- Comparison of neuroplastic responses to cathodal t...
- Editorial Board
- Author Index to Volume 119, 2017
- Development of a brief assessment of activity limi...
- IgG4-related disease presenting as hoarseness and ...
- Effect of inhaled allergens and air pollutants on ...
- Information for Readers
- Table of Contents
- rAsp f 3 and rAsp f 4 are associated with bronchie...
- Instructions for Authors
- Toxocara species exposure, symptoms of asthma, and...
- Editorial Board
- Could calcium channel blockers treat 2 illnesses w...
- Baseline asthma burden, comorbidities, and biomark...
- Increasing our knowledge base of asthma
- Innate lymphoid cells and allergic disease
- Rare cause of periorbital and eyelids lesions: Dis...
- Spectrum and prevalence of reactions to marijuana ...
- Baseline asthma burden, comorbidities, and biomark...
- The clinical role of fractional exhaled nitric oxi...
- Burden of skin pain in atopic dermatitis
- Trastuzumab emtansine: determining its role in man...
- Disrupted circuits in mouse models of autism spect...
- Biography—Q. Ping Dou
- Aesthetic Outcomes in Delayed Breast Reconstruction
- Factors necessary for independent walking in patie...
- Anterior sacral meningocele infected with Fusobact...
- Cross sectional study of serum selenium concentrat...
- Anatomic parameters of the sacral lamina for osteo...
- Comparison of transcanal endoscopic tympanoplasty ...
- Is an endoscopic or a microscopic approach optimal...
- Calcification of Thoracic and Abdominal Aneurysms ...
- Re: “Catheter Foam Sclerotherapy of Great Saphenou...
- A Rare Cause of Critical Limb Ischaemia: An Aneury...
- Late Open Surgical Conversion after Endovascular A...
- Anatomic parameters of the sacral lamina for osteo...
- Can breast cancer patients with HER2 dual-equivoca...
- Long-term efficacy analysis of the randomised, pha...
- Phase II trial of veliparib in patients with previ...
- Enlisting the willing: A study of healthcare profe...
- Are pathological high-risk features in locally adv...
- Reviewers 2017
- Eighth American Joint Committee on Cancer (AJCC) m...
- Long-term adherence with psychiatric treatment amo...
- Randomized controlled study comparing the efficacy...
- Reconstruction Special Edition, Issue 2
- Editorial Board/Aims & Scope
- Psychometric validation of the Center for Epidemio...
- Hypermethylated ZNF582 and PAX1 genes in oral scra...
- Definitive (chemo)radiotherapy is a curative alter...
- Differential roles of kallikrein-related peptidase...
- Unplanned readmission following transoral robotic ...
- Utilization of a pre-bent plate-positioning surgic...
- Cancer stem cell and its niche in malignant progre...
- Delayed clinical complete response to intensity-mo...
- Oncogenic DNA viruses found in salivary gland tumors
- Construction of mass spectra database and diagnosi...
- Reconstruction of oral cavity defect using versati...
- Prognostic value of masticatory muscle involvement...
- A network meta-analysis in comparing prophylactic ...
- Humidification mitigates acute mucosal toxicity du...
- Plasticity of oral mucosal cell sheets for acceler...
- Evaluation of the diagnostic efficacy and spectrum...
- Head and neck reconstruction with free flaps based...
- Results of a phase II randomized controlled clinic...
- How fast can treatment with overdentures improve t...
- PSAT1 is regulated by ATF4 and enhances cell proli...
- Silencing of miR-193a-5p increases the chemosensit...
- Targeting the cross-talk between Urokinase recepto...
- FAM198B is Associated with Prolonged Survival and ...
- The Impact of Smoking and TP53 mutations in lung a...
- T cells expressing checkpoint receptor TIGIT are e...
- First-in-human phase I study of single-agent vanuc...
- Merkel cell carcinoma in the age of immunotherapy:...
- Anti-cytokine autoantibodies in a patient with a h...
- Autophagy deficiency in myeloid cells exacerbates ...
- CCL5-CCR5 interactions modulate metabolic events d...
- Improved Tumor Penetration and Single-Cell Targeti...
- Radiotherapy-activated cancer-associated fibroblas...
- SIRT6 is a target of regulation by UBE3A that cont...
- Aptamer-conjugated extracellular nanovesicles for ...
- Tumor-associated fatigue in cancer patients develo...
- Intensity modulated radiation therapy and surgery ...
- A Rare Case of a Metastatic Gastrointestinal Strom...
- rAsp f 3 and rAsp f 4 are associated with bronchie...
- A longitudinal cohort study on the impact of the c...
- Deep brain stimulation for drug-resistant epilepsy
- Vaginoplasty and Perineoplasty
- The Fine Wire Technique for Flexor Tenolysis
- Dynamic Model of Applied Facial Anatomy with Empha...
- Can Ultrasound Be Used to Improve the Palpation Sk...
- Self-efficacy and Pressure Ulcer Prevention after ...
- Intrathecal Morphine for Laparoscopic Segmental Co...
-
▼
Δεκ 07
(405)
- ► Σεπτεμβρίου (6470)
-
▼
Δεκεμβρίου
(6715)
-
►
2016
(4179)
- ► Σεπτεμβρίου (638)
- ► Φεβρουαρίου (526)
- ► Ιανουαρίου (517)
Εγγραφή σε:
Σχόλια ανάρτησης (Atom)
Δεν υπάρχουν σχόλια:
Δημοσίευση σχολίου