Ultraviolet light and melanoma

Abstract

Melanoma is a clinically heterogeneous disease and current treatment strategies of the primary tumour are based on pathological criteria alone. In the recent past, several DNA and RNA sequencing studies of primary and advanced melanoma samples have identified unique relationships between somatic mutations, genomic aberrations and the genetic fingerprint of ultraviolet light radiation (UVR). The recurrent patterns of genomic alterations reveal different disease pathways, drug targets and mechanisms limiting drug response. Here we examine the known associations between the molecular categories of melanoma and the multidimensional UVR damage.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2rU2BTv