Cytokine gene polymorphism in denture stomatitis patients: A clinical study

Abstract

Objective

This clinical study investigated the association between cytokine gene polymorphism and Candida growth in DS patients.

Subjects and Methods

Saliva and blood samples of 160 complete denture wearers (80 healthy controls and 80 with DS) were collected for mycological and gene polymorphism testing, respectively. Salivary Candida growth and TNF-α, TGF-β, IL-6 and IL-10 genotypes were investigated. Data were analyzed using Student t-test, Mann-Whitney U, Chi-square analysis and Continuity (yates) correction tests (p<.05).

Results

C. albicans colony counts in saliva were significantly higher in the DS group and in the TNF-α GG genotype (p<.05). TGF-β TC GG and TGF-β CC GG haplotype was significantly higher in DS and control groups, respectively (p<.05). C. albicans colony counts were significantly higher in control group in the TGF-β TC GG haplotype (p<.05). C. glabrata colony counts were significantly higher in the DS group than the control group in IL-6 GG genotype (p<.05). The difference between DS types in IL-6 genotypes was significant with lower expression level in DS type 3 than DS type 1 and also type 2 (p≤ .01).

Conclusion

The significant differences in some genotypes of the TNF- α, TGF- β and IL-6 in DS patients are promising in understanding the host defense in DS.

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