Cytokine-targeting biologics for allergic diseases

Publication date: Available online 2 February 2018
Source:Annals of Allergy, Asthma & Immunology
Author(s): Monica G. Lawrence, John W. Steinke, Larry Borish
ObjectiveAsthma and allergic diseases continue to increase in prevalence, creating a financial burden on the health care system and impacting the quality of life for those who suffer from these diseases. Many intrinsic and extrinsic factors are involved in the initiation and maintenance of the allergic response. Cytokines are proteins with growth, differentiation, and activation functions that regulate and direct the nature of immune responses.Data Sources/Study SelectionsWe searched clinicaltrials.gov for relevant clinical trials. PubMed search was performed for recent appropriate studies.Results and ConclusionsThis review focused on cytokines involved in the allergic response with an emphasis on those for which therapies are being or have been developed.



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