RBD: a red flag for cognitive impairment in Parkinson’s disease?

The increasing evidence indicates that there is a strong association between rapid eye movement sleep behavior disorder (RBD) and Parkinson's disease - cognitive impairment (PD-CI). Numerous longitudinal and cross-sectional studies have shown that RBD may be an important risk factor and predictor of Parkinson's disease – mild cognitive impairment (PD-MCI) and Parkinson's disease dementia (PDD), which may be explained by association of mechanisms between RBD and PD-CI including neurotransmitter alterations, genetic mutation, neuroinflammation, alpha-synuclein inclusion, abnormal cerebral metabolism and slowing of cortical activity.

from #ORL-AlexandrosSfakianakis via ola Kala on Inoreader http://ift.tt/2DZ944Y